Article
Multidisciplinary Sciences
Wayne Zita, Segolene Bressoud, Gaetan Glauser, Felix Kessler, Venkatasalam Shanmugabalaji
Summary: This study provides insights into the role of plastoglobules (PG) in carotenoid accumulation during tomato fruit maturation. The research reveals changes in the PG proteome and metabolome, indicating the importance of PG as a biosynthetic platform for carotenogenesis.
Article
Green & Sustainable Science & Technology
Ghulam Murshid, Abulhassan Ali, Sahil Garg, Said Al-Jabri, Muhammad Mubashir, Pau Loke Show
Summary: The study focused on the model analysis of N-methyldiethanolamine for CO2 capture, highlighting the impact of temperature and PZ concentration on physical properties. Experimental data was used to establish empirical correlations between properties, demonstrating the importance of these findings for gas-liquid absorption system design. This work contributes to global efforts to reduce CO2 emissions in industrial processes and provides valuable insights for environmental sustainability.
SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS
(2022)
Article
Multidisciplinary Sciences
Eli Yablonovitch, Harry W. Deckman
Summary: We present a scalable and economical solution to address the carbon dioxide problem. By capturing CO2 from the atmosphere and burying harvested plants in an engineered dry biolandfill, biomass can be preserved for an extended time. This technology utilizes salt to maintain a dry environment and suppress anaerobic organisms, thus ensuring the long-term preservation of biomass and sequestration of CO2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Tamar Szoke, Nitsan Albocher, Sutharsan Govindarajan, Anat Nussbaum-Shochat, Orna Amster-Choder
Summary: TmaR, a previously unannotated protein in E. coli, localizes to the cell pole when phosphorylated on a tyrosine residue and controls the subcellular localization and activity of Enzyme I (EI) by binding and polar sequestration. The absence of TmaR leads to detrimental effects on cell survival in mild acidic conditions and affects the ability of cells to enter stationary phase, demonstrating the importance of TmaR in regulating cellular processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geosciences, Multidisciplinary
Ze Tao, Zhiliang He, Tiago M. Alves, Xiaowen Guo, Jian Gao, Sheng He, Wen Zhao
Summary: This study investigated the structural evolution in the Lijin and Boxing sags in the Dongying depression and found that inherited structures significantly control the development of overpressure in sedimentary basins.
MARINE AND PETROLEUM GEOLOGY
(2022)
Article
Multidisciplinary Sciences
Alex Shlemov, Theodore Alexandrov, Nina Golyandina, David Holloway, Stefan Baumgartner, Alexander V. Spirov
Summary: The Bicoid protein is a key determinant of early anterior-posterior axis specification in Drosophila embryogenesis. Analyzing the dynamic distribution of bcd mRNA can reveal important factors in the formation and maintenance of the Bcd protein gradient. The early developmental dynamics of bcd and Stau proteins appear to be coordinated and are crucial for understanding morphogenetic processes.
Article
Biochemistry & Molecular Biology
Mainak Bose, Marko Lampe, Julia Mahamid, Anne Ephrussi
Summary: The asymmetric localization of oskar RNP granules is crucial for embryonic development and germline formation in Drosophila. The study reveals that oskar granules are solid-like condensates that can undergo a liquid-to-solid phase transition. Modulating the material properties of the granules has significant effects on oskar localization and translation.
Article
Thermodynamics
Efstathios E. Michaelides
Summary: Carbon capture and storage involves a series of processes including separation, pressurization, transportation, storage, and monitoring, each requiring significant energy. The article calculates the minimum work requirements for separation processes and conducts a case study on a coal power plant, finding that actual energy requirements are much higher than the minimum power.
Article
Cell Biology
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen
Summary: Daxx functions as a histone chaperone for the histone H3 variant H3.3 and is essential for embryonic development. It interacts with Atrx to deposit H3.3 into heterochromatin, and this interaction is dispensable for viability. However, the interaction between Daxx and H3.3 is essential for postnatal viability and is important for silencing endogenous retroviruses and maintaining proper immune cell composition.
CELL DEATH & DISEASE
(2023)
Article
Energy & Fuels
Barbara Olfe-Kraeutlein, Till Strunge, Anna Chanin
Summary: The cement and concrete industry is under pressure to reduce CO2 emissions, with CO2 mineralization technology being a potential solution. Policy support is crucial for the development and commercialization of CCU technologies, as indicated by research.
FRONTIERS IN ENERGY RESEARCH
(2021)
Article
Thermodynamics
Kai Zhang, Hon Chung Lau, Harsha Kumar Bokka, Nanji J. Hadia
Summary: This paper evaluates the potential for mitigating CO2 emissions from the power and industry sectors in India using carbon capture and storage. The results indicate that India has significant CO2 storage capacity and relatively short distances between CO2 sources and sinks.
Article
Chemistry, Physical
Jiafei Zhao, Yanzhen Liu, Lei Yang, Lunxiang Zhang, Yongchen Song
Summary: The presence of organics-coated nanoclays in natural sediments can significantly reduce the induction time of CO2 hydrate formation, attributed to the negative charges and functional groups of the organics. This finding suggests a potentially sustainable promoting effect on hydrate formation through the unique properties of the nanoclays in complex natural environments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Oncology
Hua Su, Michael Karin
Summary: The tumor microenvironment plays a crucial role in tumor progression and maintenance. Collagens, as the most abundant proteins in the tumor microenvironment, not only act as structural elements, but also serve as important sources of nutrients and growth controlling signals. This review focuses on the role of collagens in supporting cancer cell metabolism and their impact on tumor bioenergetics, growth, progression, and response to therapy.
Article
Cell Biology
Magdalena Murawska, R. A. Greenstein, Tamas Schauer, Karl C. F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al-Sady, Sigurd Braun
Summary: The formation of heterochromatin involves nucleation, self-propagation, and maintenance steps, with the histone chaperone FACT playing a crucial role in promoting heterochromatin spreading by repressing heterochromatic histone turnover in fission yeast. This study sheds light on the mechanisms underlying the involvement of FACT in heterochromatin silencing.
Review
Microbiology
Irwan Ibrahim, Mohd Nur Ikhmal Salehmin, Krishan Balachandran, Muhammad Farhan Hil Me, Kee Shyuan Loh, Mimi Hani Abu Bakar, Bor Chyan Jong, Swee Su Lim
Summary: Microbial electrosynthesis (MES) is an emerging electrochemical technology that can convert CO2 into carbon compounds using electrogenic microbes as biocatalysts, offering a potential solution to address climate change. However, the critical component of this technology, the cathode, needs further improvement to enhance its selectivity and electrocatalytic activities. Various approaches, including cathode modification and new fabrication methods, have been explored. In addition, optimizing the operating procedure, such as hybridization and integration of MES, is crucial to reduce operating costs and improve production efficiency. If successfully realized, MES could provide a new way to utilize excess CO2 and generate profitable commodities to replace fossil fuel-derived products.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maozhi Hu, Yibei Zhang, Dan Gu, Xiang Chen, Matthew K. Waldor, Xiaohui Zhou
Summary: The study revealed that the T3SS effector VgpA in Vibrio parahaemolyticus interacts with the host cell nucleolus protein EBP2, leading to re-localization of c-Myc and increased cell proliferation. This interaction enhances EBP2 affinity for c-Myc, prolonging the oncoprotein's half-life and ultimately contributing to the pathogenesis of V. parahaemolyticus infection.
Article
Microbiology
Alyson R. Warr, Rachel T. Giorgio, Matthew K. Waldor
Summary: The function of the bacterial gene cvpA, which encodes an inner membrane protein, remains largely unknown. However, studies have shown its importance in intestinal colonization by enteric pathogens and resistance to bile salts, particularly in EHEC strains. Activation of the sigma(E)-mediated extracytoplasmic stress response pathways can restore the resistance of cvpA mutants to bile salts, suggesting a role in maintaining cell envelope homeostasis. Additionally, the conservation of CvpA across diverse bacterial phyla indicates its role in responding to various cell envelope perturbations.
JOURNAL OF BACTERIOLOGY
(2021)
Review
Microbiology
Brandon Sit, Bolutife Fakoya, Matthew K. Waldor
Summary: This article reviews non-surgical animal models currently used to study cholera, highlighting recent discoveries in the mechanisms of cholera pathogenesis and immunity, particularly in relation to the interaction between Vibrio cholerae and the gut microbiome.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abdelrahim Zoued, Hailong Zhang, Ting Zhang, Rachel T. Giorgio, Carole J. Kuehl, Bolutife Fakoya, Brandon Sit, Matthew K. Waldor
Summary: Surface protein tagging and mass spectrometry-based proteomics were used in a rabbit cholera model system to identify proteins involved in Vibrio cholera-host cell interactions, revealing a cholera toxin-dependent role for host surfactant protein D. Additionally, other host proteins were found to potentially play roles in intestinal homeostasis and host defense.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Biology
Karthik Hullahalli, Matthew K. Waldor
Summary: The study utilized the STAMPR technique to investigate population dynamics of extraintestinal pathogenic Escherichia coli during murine systemic infection and found that organ-specific clearance failures were prevalent despite most organs being able to clear bacteria, leading to clonal expansions and variations in bacterial burden between animals. Stochastic dissemination of clones was observed to profoundly alter the pathogen population structure within organs.
Article
Microbiology
Bolutife Fakoya, Karthik Hullahalli, Daniel H. F. Rubin, Deborah R. Leitner, Roma Chilengi, David A. Sack, Matthew K. Waldor
Summary: This study created next-generation cholera challenge strains and demonstrated their accuracy and safety in measuring immunity and vaccine effectiveness.
Article
Microbiology
Marija Stepanovica, Martha A. Zepeda-Rivera, Adam S. McGlinchey, Alexander A. Baryiames, Dakota S. Jones, Kaitlyn D. LaCourse, Susan Bullman, Christopher D. Johnston
Summary: The complete genome sequence of Morganella morganii CTX51T, a strain isolated from a resected tumor of a patient with cecal colorectal adenocarcinoma, is reported. The genome consists of a circular chromosome of 4.19 Mbp, with a GC content of 50.4%, and one circular plasmid of 8.48 kbp.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Microbiology
Adam S. McGlinchey, Martha A. Zeped-Rivera, Marija Stepanovica, Alexander A. Baryiames, Dakota S. Jones, Kaitlyn D. LaCourse, Susan Bullman, Christopher D. Johnston
Summary: The complete genome sequence of Clostridium cadaveris IFB3C5, isolated from a treatment naive colorectal cancer patient's resected tumor, is reported. The genome consists of a singular chromosome of approximately 3.63 Mbp in length, two plasmids, and has an overall mean GC content of 31.7%.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Multidisciplinary Sciences
Satoshi Kimura, Veerasak Srisuknimit, Kacie McCarty, Peter C. Dedon, Philip J. Kranzusch, Matthew K. Waldor
Summary: This study characterizes the C-to-psi conversion RNA editing process and its regulation, highlighting the role of the TrcP enzyme and modification network in optimizing translation efficiency.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Brandon Sit, Veerasak Srisuknimit, Emilio Bueno, Franz G. Zingl, Karthik Hullahalli, Felipe Cava, Matthew K. Waldor
Summary: The microbial cell wall, primarily composed of peptidoglycan, plays a crucial role in maintaining cell shape and resistance to external stressors. The biosynthesis and structure of peptidoglycan are responsive to environmental changes, however, the underlying mechanisms are not fully understood. In this study, DUF368 and DedA protein families were identified as candidate C55-P translocases, filling a critical gap in the knowledge of proteins involved in the biogenesis of microbial cell surface polymers. The activity of C55-P transporter was found to be essential for the growth and maintenance of cell shape in pathogenic bacteria, such as cholera.
Article
Multidisciplinary Sciences
Ian W. Campbell, Karthik Hullahalli, Jerrold R. Turner, Matthew K. Waldor
Summary: In this study, the authors investigated the effect of pathogen dose on the initiation of infection in the mouse gut using Citrobacter rodentium as a model. They found that host bottlenecks prevent infections by eliminating invading pathogens, and the size of the pathogen's founding population in female mice is controlled by a severe bottleneck. The disruption of the microbiota was found to be the dominant bottleneck, while the loss of the critical virulence island led to a contraction in the diversity of the pathogen population.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Daniel H. F. Rubin, Kevin C. Ma, Kathleen A. Westervelt, Karthik Hullahalli, Matthew K. Waldor, Yonatan H. Grad
Summary: The evolution of Neisseria gonorrhoeae as a human pathogen is influenced by diverse host environments and antibiotics. Variations in antibiotic resistance across N. gonorrhoeae lineages indicate that metabolic differences may affect the acquisition of specific resistances. A study found that the requirement for supplemental CO2 in some isolates is due to a single substitution in a beta-carbonic anhydrase, CanB. This metabolic variation also influences fluoroquinolone resistance in N. gonorrhoeae by increasing the likelihood of acquisition.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fei Pan, Mingli Zhu, Ying Liang, Chen Yuan, Yu Zhang, Yuchang Wang, Hongjie Fan, Matthew K. Waldor, Zhe Ma
Summary: M family proteins are important virulence determinants of Streptococci, and SzM, an M protein of SEZ, is linked to SEZ brain invasion. This study demonstrates that SzM plays a crucial role in SEZ disruption of the blood-brain barrier (BBB). SEZ releases SzM-bound membrane vesicles (MVs), which are taken up by human brain endothelial microvascular cells (hBMECs) and result in SzM-dependent cytotoxicity. Furthermore, administration of SzM-bound MVs disrupts the murine BBB.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Christina Lang, Angelika Fruth, Ian W. Campbell, Claire Jenkins, Peyton Smith, Nancy Strockbine, Francois-Xavier Weill, Ulrich Nuebel, Yonatan H. Grad, Matthew K. Waldor, Antje Flieger
Summary: STEC O104:H4 outbreak strain remains a global threat due to similar strains causing disease worldwide, but the diversification of O-antigens in ST678 strains has made their identification difficult. A rare STEC serotype, O181:H4, associated with HUS, was identified in Germany, and this strain is phylogenetically related to the STEC O104:H4 outbreak strain. Other serotypes belonging to ST678 were also identified from human clinical infections worldwide, including OX13:H4, O127:H4, OgN-RKI9:H4, O131:H4, and O69:H4.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Brandon Sit, Veerasak Srisuknimit, Emilio Bueno, Franz G. Zingl, Karthik Hullahalli, Felipe Cava, Matthew K. Waldor
Summary: The microbial cell wall is important for maintaining cell shape and resistance to external stressors. Peptidoglycan is the primary structural component of the cell wall and its synthesis and structure are responsive to environmental conditions. The DUF368 and DedA protein families have been identified as candidate C55-P translocases, playing a critical role in the biogenesis of microbial cell surface polymers.