Article
Multidisciplinary Sciences
Yang Zhou, Yekun Deng, Zhongmin Liu, Mengyuan Yin, Mengying Hou, Ziyin Zhao, Xiaozhong Zhou, Lichen Yin
Summary: Nanodecoys capable of scavenging RANKL and TNF-alpha were developed from preosteoclast membrane-coated PLGA nanoparticles to inhibit osteoporosis and maintain bone integrity. These biomimetic nanodecoys effectively neutralized RANKL and TNF-alpha, preventing osteoclast formation and promoting osteoblast formation, thus reversing the progression of osteoporosis in the OVX mouse model.
Review
Biochemistry & Molecular Biology
Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi
Summary: TNF-alpha is a cytokine expressed by immune cells and is involved in host defense and bone-related cell functions. This review summarizes current research on the interaction between TNF-alpha and its receptors in bone cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Haiyuan Xing, Ruiyan Li, Yun'an Qing, Boda Ying, Yanguo Qin
Summary: Through the study of Osteoimmunomodulation (OIM) and the TLR4-NF-kappa B pathway, it has been found that immune cells play a crucial role in bone integration and healing, leading to a better understanding of the mechanism behind bone regeneration.
APPLIED MATERIALS TODAY
(2021)
Article
Immunology
Tarannum Taznin, Kaushalya Perera, Yann Gibert, Alister C. Ward, Clifford Liongue
Summary: This study investigated the expression and function of CRLF3, an evolutionarily significant protein, in early development, particularly in blood and immune cells, using zebrafish as a model. The study found that CRLF3 was expressed in multiple embryonic tissues and played a crucial role in primitive hematopoiesis and early definitive hematopoiesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
George Fromm, Suresh de Silva, Taylor H. Schreiber
Summary: The extracellular domain of tumor necrosis factor receptors (TNFR) needs to assemble into a homotrimeric quaternary structure in order to initiate signaling. Synthetic agonists targeting TNF receptors have potential clinical benefits in amplifying immune responses, but their translation into human clinical studies has been limited and raised questions about the biology of TNF receptors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Maria-Bernadette Madel, Julia Halper, Lidia Ibanez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach
Summary: This study explores the specific traits of inflammatory and steady-state osteoclasts using transcriptomic profiling, differentiation assays, and in vivo analysis in mice. The authors identify and validate pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle as major regulators of inflammatory osteoclasts. They demonstrate that the administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) reduces bone loss in ovariectomized mice by regulating the inflammatory environment and inhibiting inflammatory osteoclastogenesis. The study also shows that Sb derivatives and agonists of Tlr2, Dectin-1, and Mincle specifically inhibit the differentiation of inflammatory osteoclasts in vitro. These findings have important implications for the development of therapeutic strategies for inflammatory bone loss.
Article
Oncology
Shanglin Li, Ruocong Zhao, Diwei Zheng, Le Qin, Yuanbin Cui, Yao Li, Zhiwu Jiang, Mengjun Zhong, Jingxuan Shi, Ming Li, Xindong Wang, Zhaoyang Tang, Qiting Wu, Youguo Long, Duo Hu, Suna Wang, Yao Yao, Shuang Liu, Li-Hua Yang, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Yangqiu Li, Peng Li
Summary: A novel dual-targeting system utilizing DAP10 chimeric receptor and anti-GPC3 scFv was designed to enhance the efficacy of CAR-T cells against solid tumors, showing successful elimination of heterogeneous cancer cells in vitro and in vivo.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Oncology
Ilaria Grazia Zizzari, Alessandra Di Filippo, Andrea Botticelli, Lidia Strigari, Angelina Pernazza, Emma Rullo, Maria Gemma Pignataro, Alessio Ugolini, Fabio Scirocchi, Francesca Romana Di Pietro, Ernesto Rossi, Alain Gelibter, Giovanni Schinzari, Giulia D'Amati, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti, Chiara Napoletano
Summary: CD137(+) T cells recognize and react to tumors, and high levels of CD137(+) T cells are associated with better clinical status and longer survival, while immunosuppressive sCD137 is associated with poor survival. CD137(+) T cells can serve as a biomarker for successful immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield, Lazar Vujanovic
Summary: TNFR2 is expressed in BRAF-mutant melanoma cells and is involved in solTNF-driven resistance to MAPKi. TNFR2 may serve as a biomarker to identify melanoma patients who can benefit from solTNF-targeting therapies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shengran Wang, Jonathan Greenbaum, Chuan Qiu, Yun Gong, Zun Wang, Xu Lin, Yong Liu, Pei He, Xianghe Meng, Qiang Zhang, Hui Shen, Krishna Chandra Vemulapalli, Fernando L. Sanchez, Martin R. Schiller, Hongmei Xiao, Hongwen Deng
Summary: This study reveals the interactions between immune cells and osteoblastic lineage cells, and identifies genes related to bone development and metabolism. It also explores the effects of immune cells in peripheral circulation on skeletal phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Summary: The study indicates that the increase in Th17 cell frequency and IL-17 levels in postmenopausal women may be associated with decreased bone density, possibly due to estrogen deficiency. Th17 cells and IL-17 could be potential targets for immunotherapy in the treatment of osteoporosis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Feng Zhou, Guorui Zhang, Yingying Wu, Yi Xiong
Summary: Inflammasome complexes play a vital role in the inflammatory response and are crucial for the interaction between the skeletal and immune systems. They regulate cell ratios and osteoclastogenesis in various bone diseases and are associated with clinical therapies. In addition, the paper discusses inflammasome complexes and their relevance to bone diseases, providing insights for future research on inflammasomes, osteoimmunology, and bone diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alexandre Paccalet, Claire Crola Da Silva, Laura Mechtouff, Camille Amaz, Yvonne Varillon, Charles de Bourguignon, Regine Cartier, Cyril Prieur, Danka Tomasevic, Nathalie Genot, Simon Leboube, Francois Derimay, Gilles Rioufol, Eric Bonnefoy-Cudraz, Nathan Mewton, Michel Ovize, Gabriel Bidaux, Thomas Bochaton
Summary: The circulating concentrations of sTNFR1 and sTNFR2 are inflammatory markers of morphological and functional injury after STEMI, and can predict clinical outcomes in patients. Patients with higher levels of sTNFR1 or sTNFR2 are more likely to experience adverse events within 24 months after suffering from STEMI. Soluble TNFR1 is an independent predictor of major adverse cardiovascular events and outperforms troponin I in predicting outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Susan MacLauchlan, Priyanka Kushwaha, Albert Tai, Sijia Chen, Catherine Manning, Gaurav Swarnkar, Yousef Abu-Amer, Katherine A. Fitzgerald, Shruti Sharma, Ellen M. Gravallese
Summary: Stimulator of interferon genes (STING) mediates interferon signaling and plays a crucial role in regulating homeostatic processes, including osteoclast differentiation and bone homeostasis. STING prevents trabecular bone loss in mice and influences osteoclast precursor differentiation through the regulation of interferon-stimulated genes (ISGs). These findings provide evidence for the important role of STING pathway in bone homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Wanyi Huang, Ziqi Zhang, Yueyang Qiu, Yuan Gao, Yongqiang Fan, Qiang Wang, Qing Zhou
Summary: Implant surgery triggers inflammatory reactions that impact postoperative outcomes. The inflammasome has a crucial role in inflammation, inducing pyroptosis and producing interleukin-1 beta. The activation of the inflammasome in bone healing after implant surgery needs to be studied. Research has focused on metal-induced NLRP3 inflammasome activation due to the prominence of metals as implant materials. This review consolidates knowledge on NLRP3 inflammasome structures, activation mechanisms, and metal-induced NLRP3 inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Rouven Schoppmeyer, Abraham C. van Steen, Lanette Kempers, Anne L. Timmerman, Martijn A. Nolte, Pleun Hombrink, Jaap D. van Buul
Summary: This study investigates how cytotoxic T lymphocytes (CTLs) efficiently leave the circulation to target cancer cells or contribute to inflammation by crossing the endothelium. The researchers found that human central memory CTLs predominantly cross the endothelium in a paracellular fashion, while effector and effector memory CTLs preferentially cross in a transcellular fashion. The study also reveals the mechanism of CTL-endothelium interaction and the involvement of ICAM-1 and CX3CL1:CX3CR1 in transcellular migration.
Article
Cell Biology
Marieke Goedhart, Edith Slot, Maria F. Pascutti, Sulima Geerman, Timo Rademakers, Benjamin Nota, Stephan Huveneers, Jaap D. van Buul, Katherine C. MacNamara, Carlijn Voermans, Martijn A. Nolte
Summary: Apart from controlling hematopoiesis, the bone marrow also functions as a secondary lymphoid organ. Bone marrow-resident dendritic cells (DCs) are mainly localized around sinusoids and can present antigens. They belong to the cDC2 subtype and are associated with Th2/Th17 immunity. These DCs express several c-type lectins, including Dectin-1, which can bind fungal beta-glucans. Compared to spleen DCs, bone marrow DCs are more efficient in phagocytosing yeast particles and Aspergillus conidia, and this is dependent on Dectin-1. Additionally, zymosan-stimulated bone marrow DCs enhance neutrophil differentiation and maintenance of progenitor cells.
Editorial Material
Cell Biology
Katherine C. MacNamara, Martijn A. Nolte
Article
Immunology
Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit
Summary: CD4(+) T cells play a role in immune responses depending on the environment and stage, with nutrient availability also impacting their functionality. TNFR2 has been identified as key in regulating T cells, particularly Tregs. This study provides new evidence for the role of TNFR2 in metabolic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Raquel S. Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M. Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N. Berneman, Benoit Beuselinck, Kalijn F. Bol, Jannie Borst, An Coosemans, Angeliki Datsi, Jitka Faucikova, Lisa Kinget, Bart Neyns, Gerty Schreibelt, Evelien Smits, Rudiger Sorg, Radek Spisek, Kris Thielemans, Sandra Tuyaerts, Steven De Vleeschouwer, I. Jolanda M. de Vries, Yanling Xiao, Abhishek D. Garg
Summary: DC-based vaccination for cancer treatment has advanced significantly over recent decades, but still shows suboptimal anti-tumor efficacy in the clinic. Current efforts are focused on improving the immunogenicity and efficacy of DC vaccines in oncology.
Article
Dentistry, Oral Surgery & Medicine
Sune Demant, Ton Schoenmaker, Sophie M. G. van Erck, Sally Dabelsteen, Teun J. de Vries, Lars Bjorndal
Summary: The formation of dense connective tissue within the dental pulp and its association with pulpal inflammation in teeth with advanced carious lesions were investigated in this study. In addition, the study investigated whether inflammation affects the expression of markers related to chondrogenesis/osteogenesis in pulp cells in vitro.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Oncology
Lars Guelen, Thierry O. Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Babala, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K. Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M. Beebe, Hans Van Eenennaam
Summary: MK-5890, a novel CD27 agonistic antibody, has the potential to complement PD-1 checkpoint inhibition in cancer immunotherapy and is currently undergoing clinical evaluation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Article
Multidisciplinary Sciences
Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D. Garg, Jannie Borst, Yanling Xiao
Summary: Despite their low abundance, cDC1s play a crucial role in anti-cancer immunity and are positively associated with patient survival. This study demonstrates that contact with activated CD4(+) T-cells enables cDC1s to induce a CTL response. The transcriptomic signature of helped cDC1s correlates with tumor infiltration by CTLs, Thelper(h)-1 cells, and overall survival.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Mark Mensink, Ellen Schrama, Eloy Cuadrado, Derk Amsen, Sander de Kivit, Jannie Borst
Summary: This study finds that induced Treg cells in humans have distinct protein expression patterns compared to blood-derived inherent Treg and conventional T cells. While induced Treg cells share some signaling and metabolic proteins with inherent Treg cells, they are more similar to conventional T cells.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ton Schoenmaker, Joy Zwaak, Bruno G. Loos, Richard Volckmann, Jan Koster, E. Marelise W. Eekhoff, Teun J. de Vries
Summary: Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification that leads to immobility and premature death. It is caused by a mutation in the ACVR1 gene, resulting in altered response to Activin-A. Activin-A induces changes in osteoclastogenesis at the gene expression level, regardless of the presence of the mutated ACVR1 receptor. RNA sequencing analysis revealed differentially expressed genes and enriched pathways associated with osteoclast differentiation, cell fusion, and inflammation. These findings suggest that Activin-A plays a significant role in gene expression during osteoclast formation in FOP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Karina E. Pigeaud, Melanie L. Rietveld, Aster F. Witvliet, Jolanda M. A. Hogervorst, Chen Zhang, Tim Forouzanfar, Nathalie Bravenboer, Ton Schoenmaker, Teun J. de Vries
Summary: Sclerostin is an inhibitor of bone formation produced by osteocytes, and it has been reported to be expressed in periodontal ligament fibroblasts as well. This study aimed to explore the role of sclerostin and its inhibitor romosozumab in osteogenesis and osteoclastogenesis. The results showed that sclerostin did not affect the osteogenic capacity of periodontal ligament fibroblasts, while romosozumab slightly reduced osteoclast formation in co-cultures with peripheral blood mononuclear cells at high concentrations. Further analysis revealed significant differences in the expression of SOST and its receptors between osteocytes and periodontal ligament cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Teun J. de Vries, Antonella S. Kleemann, Jianfeng Jin, Ton Schoenmaker
Summary: Metformin has differential effects on bone cells, promoting bone formation while inhibiting bone resorption. It lowers the expression of negative regulators of bone formation in osteocytes and shifts the osteoblasts' regulation of bone resorption towards decrease RANKL expression and increase OPG expression. Metformin also activates bone formation parameters in osteoblast lineage cells and inhibits osteoclast formation and activity. These effects are likely mediated by the activation of phosphorylated AMP kinase (AMPK). Overall, metformin shows promising potential as a drug in the field of bone research.
CURRENT OSTEOPOROSIS REPORTS
(2023)