The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

(2010) Kristen F. Swaney et al.   Annual Review of Biophysics

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

(2010) Pascale G. Charest et al.   DEVELOPMENTAL CELL

The ROCO Kinase QkgA Is Necessary for Proliferation Inhibition by Autocrine Signals in Dictyostelium discoideum

(2010) Jonathan E. Phillips et al.   EUKARYOTIC CELL

Characterization of the Roco Protein Family in Dictyostelium discoideum

(2010) Wouter N. van Egmond et al.   EUKARYOTIC CELL

Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development

(2010) Sabrina Zechel et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The exocytic gene secA is required for Dictyostelium cell motility and osmoregulation

(2010) R. Zanchi et al.   JOURNAL OF CELL SCIENCE

A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics

(2010) Andrea Meixner et al.   MOLECULAR & CELLULAR PROTEOMICS

Understanding eukaryotic chemotaxis: a pseudopod-centred view

(2010) Robert H. Insall   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks

(2009) Robert H. Insall et al.   DEVELOPMENTAL CELL

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

Filamins Regulate Cell Spreading and Initiation of Cell Migration

(2009) Massimiliano Baldassarre et al.   PLoS One

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Actin binding domains direct actin-binding proteins to different cytoskeletal locations

(2008) Raymond W Washington et al.   BMC CELL BIOLOGY

Spatiotemporal Regulation of Ras Activity Provides Directional Sensing

(2008) Sheng Zhang et al.   CURRENT BIOLOGY

Regulation of contractile vacuole formation and activity in Dictyostelium

(2008) Fei Du et al.   EMBO JOURNAL

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Directional sensing during chemotaxis

(2008) Christopher Janetopoulos et al.   FEBS LETTERS

Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC

(2008) Wouter N. van Egmond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ancient Origin of the Parkinson Disease Gene LRRK2

(2008) Ignacio Marín   JOURNAL OF MOLECULAR EVOLUTION