O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

(2012) Jessica E Rexach et al.   Nature Chemical Biology

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome

(2011) C. N. Keembiyehetty et al.   JOURNAL OF CELL SCIENCE

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

(2010) Kristin T. Jacobsen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAcylation/Phosphorylation Cycling at Ser10Controls Both Transcriptional Activity and Stability of Δ-Lactoferrin

(2010) Stéphan Hardivillé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new DAF-16 isoform regulates longevity

(2010) Eun-Soo Kwon et al.   NATURE

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity

(2010) D. C. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

(2009) Ehud Cohen et al.   AGING CELL

Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts

(2009) Kai Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

(2009) John A. Hanover et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development

(2009) Danielle M Webster et al.   BMC DEVELOPMENTAL BIOLOGY

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE

Cytosolic O-glycosylation is abundant in nerve terminals

(2003) Robert N. Cole et al.   JOURNAL OF NEUROCHEMISTRY