Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Oncology
Junyuan Xie, Li Gan, Bingjian Xue, Xinxing Wang, Xinhong Pei
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide. Non-coding RNAs, especially lncRNAs, have been found to play important roles in breast cancer. The study of epigenetic modifications has also contributed to the understanding of the role of ncRNAs in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Genetics & Heredity
Jing Li, Chang-Yu Qiu, Yue-Jin Tao, Lei Cheng
Summary: Chronic rhinosinusitis (CRS) has caused a significant socioeconomic burden, but its underlying mechanism remains unclear, possibly involving genetic, environmental, and other factors. Epigenetic analyses, including DNA methylation, histone modification, and non-coding RNA regulation, have made important breakthroughs in understanding CRS, particularly in the field of microRNAs, in the past 5 years. Epigenetic therapies may be developed to treat CRS in the future.
FRONTIERS IN GENETICS
(2023)
Review
Genetics & Heredity
Barbara Cugalj Kern, Katarina Trebusak Podkrajsek, Jernej Kovac, Robert Sket, Barbara Jenko Bizjan, Tine Tesovnik, Marusa Debeljak, Tadej Battelino, Natasa Bratina
Summary: Long-term hyperglycemia caused by type 1 diabetes has a significant impact on epigenetic marks in late complications, such as DNA methylation, histone modifications, and microRNAs.
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo
Summary: This article describes the epigenetic changes that occur in the pathogen Mycobacterium tuberculosis and its host during infection, including DNA methylation, histone modification, and microRNA. It summarizes the research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat drug-resistant tuberculosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Farzin Zobdeh, Ivan I. Eremenko, Mikail A. Akan, Vadim V. Tarasov, Vladimir N. Chubarev, Helgi B. Schioeth, Jessica Mwinyi
Summary: Migraine is a complex neurological disorder and current drug treatments have limited success rates. Understanding the epigenetic changes associated with migraine may help to improve treatment strategies and identify new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Cell Biology
Liang Zhang, Chenhai Xia, Yongjun Yang, Fangfang Sun, Yu Zhang, Huan Wang, Rui Liu, Ming Yuan
Summary: Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up in arterial vessel walls, acting as a major cause of cardiovascular diseases. Epigenetic modifications are increasingly associated with atherosclerosis and have implications for therapy and biomarker research.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Neurosciences
Maria A. Kasherman, Susitha Premarathne, Thomas H. J. Burne, Stephen A. Wood, Michael Piper
MOLECULAR NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Joana A. Revez, Tian Lin, Zhen Qiao, Angli Xue, Yan Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, Julia Sidorenko, Kathryn E. Kemper, Anna A. E. Vinkhuyzen, Julanne Frater, Darryl Eyles, Thomas H. J. Burne, Brittany Mitchell, Nicholas G. Martin, Gu Zhu, Peter M. Visscher, Jian Yang, Naomi R. Wray, John J. McGrath
NATURE COMMUNICATIONS
(2020)
Review
Neurosciences
Kyna-Anne Conn, Thomas H. J. Burne, James P. Kesby
FRONTIERS IN NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Xiaoying Cui, John J. McGrath, Thomas H. J. Burne, Darryl W. Eyles
Summary: Numerous epidemiological studies have linked vitamin D deficiency with schizophrenia, particularly in newborns. Research suggests that early-life vitamin D deficiency may increase the risk of developing schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Marija Kojic, Tomasz Gawda, Monika Gaik, Alexander Begg, Anna Salerno-Kochan, Nyoman D. Kurniawan, Alun Jones, Katarzyna Drozdzyk, Anna Koscielniak, Andrzej Chramiec-Glabik, Soroor Hediyeh-Zadeh, Maria Kasherman, Woo Jun Shim, Enakshi Sinniah, Laura A. Genovesi, Rannva K. Abrahamsen, Christina D. Fenger, Camilla G. Madsen, Julie S. Cohen, Ali Fatemi, Zornitza Stark, Sebastian Lunke, Joy Lee, Jonas K. Hansen, Martin F. Boxill, Boris Keren, Isabelle Marey, Margarita S. Saenz, Kathleen Brown, Suzanne A. Alexander, Sergey Mureev, Alina Batzilla, Melissa J. Davis, Michael Piper, Mikael Boden, Thomas H. J. Burne, Nathan J. Palpant, Rikke S. Moller, Sebastian Glatt, Brandon J. Wainwright
Summary: The study identifies biallelic variants in the ELP2 gene causing intellectual disability (ID) and autism spectrum disorder (ASD), which lead to brain abnormalities in patients. The mutations negatively impact the activity of the Elongator complex and its function in brain development.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Jonathan Flintoff, James P. Kesby, Dan Siskind, Thomas H. J. Burne
Summary: To understand the benefits of GLP-1 RAs in individuals with schizophrenia, further preclinical research with rodent models relevant to schizophrenia symptomology is needed. Moreover, preclinical studies must focus on using a wider range of behavioral assays to understand whether important aspects of cognition such as executive function, attention, and goal-directed behavior are improved using GLP-1 RAs. Further research into the specific mechanisms of how GLP-1 RAs affect cognitive function and their interactions with antipsychotic medication commonly prescribed is necessary.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2021)
Article
Oncology
Hamza Celik, Ethan Krug, Christine R. Zhang, Wentao Han, Nancy Issa, Won Kyun Koh, Hassan Bjeije, Ostap Kukhar, Maggie Allen, Tiandao Li, Daniel A. C. Fisher, Jared S. Fowles, Terrence N. Wong, Matthew C. Stubbs, Holly K. Koblish, Stephen T. Oh, Grant A. Challen
Summary: Myeloproliferative neoplasms (MPNs) are chronic blood diseases with significant morbidity and mortality. Despite well-defined genetic events, therapeutic discovery has been hindered by the limitations of mouse models. A humanized animal model using patient-derived xenografts has been introduced, providing a platform for studying MPN biology and potential therapeutic targets.
Article
Cell Biology
Ranita J. Atcheson, Thomas H. J. Burne, Paul A. Dawson
Summary: Sulfate is crucial for foetal growth and neurodevelopment, and the SLC13A1 sulfate transporter regulates sulfate reabsorption in the kidney. Previous studies showed that severe vitamin D deficiency affects sulfate homeostasis in rodents. However, this study found that moderate vitamin D deficiency did not impact sulfate levels or the expression of the SLC13A1 gene in mice. The researchers also discovered differences in the regulation of SLC13A1 between mouse and human cells, suggesting that the effects of vitamin D deficiency on sulfate homeostasis may vary between species.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Behavioral Sciences
Kyna-Anne Conn, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: This study examines the role of D1 and D2 receptors in learning induced by amphetamine. The results suggest that overall D1 receptor availability is crucial for learning, while modifying D2 receptor function can ameliorate learning deficits in a state of elevated dopamine.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Chemistry, Medicinal
Harrison Y. R. Madge, Suzy Alexander, Armira Azuar, Jiahui Zhang, Prashamsa Koirala, Thomas H. Burne, Istvan Toth, Rachel J. Stephenson
Summary: Researchers have developed a peptide-based anti-cocaine vaccine that can induce immune responses in mice, providing a platform for the development of effective anti-drug vaccines.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Kyna-Anne Conn, Simin Zou, Joyosmita Das, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: In this study, the cognitive symptoms of schizophrenia, including impaired goal-directed action, were found to be associated with altered dopamine signaling in the brain. The differential roles of the dorsomedial and ventral inputs into the striatum in goal-directed action were identified, providing insights into the cognitive problems in schizophrenia.
Article
Neurosciences
Madison K. Young, Kyna-Anne Conn, Joyosmita Das, Simin Zou, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: The DMS plays a multifaceted role in reversal learning, impacting multiple processes dependent on the level of uncertainty. Increasing DMS activity impairs decision-making processes and suggests a potential link to decision-making impairments in individuals with psychosis.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Oncology
Christine R. Zhang, Elizabeth L. Ostrander, Ostap Kukhar, Cates Mallaney, Jiameng Sun, Emily Haussler, Hamza Celik, Won Kyun Koh, Katherine Y. King, Paul Gontarz, Grant A. Challen
Summary: Clonal hematopoiesis (CH) is the age-related expansion of specific clones in the blood system, often associated with mutations in the gene DNMT3A. Despite the prevalence of DNMT3A mutations in CH, a unified molecular mechanism explaining the competitive advantage of DNMT3A-mutant HSCs is currently lacking.
BLOOD CANCER DISCOVERY
(2022)
Article
Neurosciences
Md Mamun Al-Amin, Robert K. P. Sullivan, Suzy Alexander, David A. Carter, DanaKai Bradford, Thomas H. J. Burne
Summary: Vitamin D deficiency in adults can lead to cognitive impairment. This study found that deficiency in adult vitamin D affects spatial memory in mice and that decreased levels of NO and reduced nNOS immunoreactivity may contribute to this impairment.
Article
Neurosciences
Maria A. Kasherman, Laura Currey, Nyoman D. Kurniawan, Oressia Zalucki, Michelle Sanchez Vega, Lachlan A. Jolly, Thomas H. J. Burne, Stephen A. Wood, Michael Piper
Summary: Research has identified USp9X as a key regulator of brain formation and function, shedding light on the neurodevelopmental syndrome associated with USp9X mutations in patients.