Altering cancer transcriptomes using epigenomic inhibitors

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway

(2015) Wei Xu et al.   CANCER LETTERS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth

(2014) M. D. Arensman et al.   MOLECULAR CANCER THERAPEUTICS

Prognostic significance of WNT signaling in pancreatic ductal adenocarcinoma

(2014) Mitsuhiro Nakamoto et al.   VIRCHOWS ARCHIV

An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer

(2013) Jinping Jia et al.   BMC Medical Genomics

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

(2013) Y. Zhang et al.   CANCER RESEARCH

Molecular Pathways: Sterols and Receptor Signaling in Cancer

(2013) L. Gabitova et al.   CLINICAL CANCER RESEARCH

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

SREBP: a novel therapeutic target

(2012) X. Xiao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Regulation of cholesterol biosynthesis and cancer signaling

(2012) Andrey Gorin et al.   CURRENT OPINION IN PHARMACOLOGY

Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: A meta-analysis of randomised trials

(2012) Domenico Ciliberto et al.   EUROPEAN JOURNAL OF CANCER

Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance

(2012) Andrew J. Vincent et al.   FEBS LETTERS

Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

(2012) Dong Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

(2012) Tewfik Hamidi et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

p8 Expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis

(2011) Maria Jose Sandi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting the epigenome for treatment of cancer

(2011) E-J Geutjes et al.   ONCOGENE

Wnt/β-catenin Signaling in Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming

(2011) Toshio Miki et al.   Stem Cell Reviews and Reports

Molecular biology of pancreatic cancer

(2011) Miroslav Zavoral   WORLD JOURNAL OF GASTROENTEROLOGY

The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators

(2010) Jia-Ling Teo et al.   ADVANCED DRUG DELIVERY REVIEWS

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

(2010) Roelof Koster et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation

(2010) Y. F. M. Ramos et al.   NUCLEIC ACIDS RESEARCH

Further case of Rubinstein-Taybi syndrome due to a deletion in EP300

(2009) Patricia Foley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

Wnt signaling inside the nucleus

(2008) Miki Shitashige et al.   CANCER SCIENCE

NUPR1 Interacts with p53, Transcriptionally Regulates p21 and Rescues Breast Epithelial Cells from Doxorubicin-Induced Genotoxic Stress

(2008) David Clark et al.   CURRENT CANCER DRUG TARGETS

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function

(2008) Ling Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY