Article
Oncology
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Summary: The study identified a significant presence of CD8+CD103+ TRMs in cutaneous squamous cell carcinomas, with their expression in the tumor being associated with poorer clinical outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Saad M. Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P. Dunn, Allegra Petti, Tanner M. Johanns
Summary: Dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion in glioblastoma, influencing the efficacy of PD-1 blockade. Adding a CD40 agonist to PD-1 blockade therapy improves survival rates in glioblastoma, suggesting a potential synergistic immunotherapeutic approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Kathrin Davari, Tristan Holland, Laura Prassmayer, Giulia Longinotti, Kenneth P. Ganley, Lisa J. Pechilis, Iulia Diaconu, Prashant R. Nambiar, Michael S. Magee, Dolores J. Schendel, Daniel Sommermeyer, Christian Ellinger
Summary: A MAGE-A4-reactive, HLA-A2-restricted T-cell receptor (TCR) with high avidity was isolated from HLA-A2-negative donors, demonstrating favorable safety and superior in vivo potency. This non-mutated TCR was CD8 co-receptor independent, allowing activation of CD4(+) T cells and enhancing anti-tumor response. The pre-clinical assessment suggests potential for enhanced cellular responses in clinical TCR-T immunotherapy studies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Eric Y. Helm, Tomas Zelenka, Valeriu B. Cismasiu, Shamima Islam, Leonardo Silvane, Beatrice Zitti, Tim D. Holmes, Theodore T. Drashansky, Alexander J. Kwiatkowski, Christine Tao, Joseph Dean, Alyssa N. Obermayer, Xianghong Chen, Benjamin G. Keselowsky, Weizhou Zhang, Zhiguang Huo, Liang Zhou, Brian S. Sheridan, Jose R. Conejo-Garcia, Timothy I. Shaw, Yenan T. Bryceson, Dorina Avram
Summary: In this study, the role of the transcription factor Bcl11b in TRM cells was investigated during infection with Listeria monocytogenes. Conditional deletion of Bcl11b resulted in increased numbers of intestinal TRM cells, decreased splenic effector and circulating memory cells, and altered transcriptional programs in TRM cells with decreased expression of multipotent/multifunctional genes and upregulation of effector genes.
SCIENCE IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Wang, Jing Zhao, Changlong Hao, Shudong Hu, Chen Chen, Yi Cao, Zhengyu Xu, Jun Guo, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuang
Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Article
Biology
Agnese Losurdo, Caterina Scirgolea, Giorgia Alvisi, Jolanda Brummelman, Valentina Errico, Luca Di Tommaso, Karolina Pilipow, Federico Simone Colombo, Bethania Fernandes, Clelia Peano, Alberto Testori, Corrado Tinterri, Massimo Roncalli, Armando Santoro, Emilia Maria Cristina Mazza, Enrico Lugli
Summary: By analyzing breast cancer-infiltrating T cells using high-dimensional single-cell technologies, researchers found that a small subset of tissue-resident memory CD8+ T cells with enhanced degranulation capacity is associated with positive prognosis in luminal-like breast cancer, highlighting the potential importance of specific T cell immune microenvironment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Bin Yuan, Curtis A. Clark, Bogang Wu, Jing Yang, Justin M. Drerup, Tianbao Li, Victor X. Jin, Yanfen Hu, Tyler J. Curiel, Rong Li
Summary: The study identified the role of the ER beta phosphotyrosine switch in regulating ER beta-dependent antitumor immunity in CD8(+) T cells, supporting the development of ER beta agonists in combination with ICB immunotherapy for cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Juan Estrada, Jinghui Zhan, Petia Mitchell, Jonathan Werner, Pedro J. Beltran, Jason DeVoss, Jing Qing, Keegan S. Cooke
Summary: In a mouse tumor model, combination treatment with OncoVEX(mGM-CSF) and checkpoint inhibitors led to increased tumor growth inhibition, reduced lung metastases, and prolonged animal survival. OncoVEX(mGM-CSF) induced both neoantigen-specific and tumor antigen-specific T-cell responses. These findings suggest that the combination of T-VEC and checkpoint inhibition may be effective in treating patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Angela Castoldi, Jennifer Lee, Daniel de Siqueira Carvalho, Fabricio Oliveira Souto
Summary: Immunometabolism has advanced our understanding of how cellular environment and nutrient availability regulate immune cell fate. Dysregulation of immune cell metabolism plays an essential role in the progression of diseases including breast cancer. CD8(+) T cells are crucial in the tumor microenvironment and their metabolic changes are important for tumor progression. However, identifying specific CD8(+) T cell subtypes in breast cancer remains challenging.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
David Noyes, Arup Bag, Saheed Oseni, Jon Semidey-Hurtado, Ling Cen, Amod A. Sarnaik, Vernon K. Sondak, Dennis Adeegbe
Summary: This study demonstrates that the accumulation of Tregs contributes to the dysfunction and clonal constriction of tumor-infiltrating CD8 +T cells. The dysfunctional phenotype of CD8 +T cells is reversed upon reduction of Tregs, and this is mediated by Treg-expressed CTLA-4.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)