Article
Chemistry, Analytical
Alexander Ruf, Gregoire Danger
Summary: The mol2net method has been used to generate and analyze molecular networks of complex astrochemical data in an unsupervised and data-driven manner. The study significantly refines the structural characterization of large complex organic molecules in interstellar ice analogs, providing additional information on key transformations and molecular structures.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Alexander Ruf, Gregoire Danger
Summary: This article presents a method for generating and analyzing complex astrochemical data using a data-driven and unsupervised approach. The results demonstrate that this method significantly improves the structural characterization of large complex organic molecules in interstellar ice analogs.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Achraf Abdou, Fatima Ezzahra Maaghloud, Abdelhakim Elmakssoudi, Aziz Aboulmouhajir, Jamal Jamal Eddine, Mohamed Dakir
Summary: Eugenol, a plant bioactive component, was extracted from clove buds and analyzed using GC/MS. The major constituent of the essential oil was found to be eugenol. The reactivity of eugenol with aluminum chloride hydrate was investigated using DFT, and the results were in good agreement with the experimental findings.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
George Karageorgis, Daniel J. Foley, Luca Laraia, Susanne Brakmann, Herbert Waldmann
Summary: PNPs are compounds formed by combining NP fragments in unique ways, inheriting important biological characteristics of NPs while exhibiting unprecedented bioactivity. The importance of design principles, synthesis, and biological research on PNP scaffolds is emphasized. PNPs are considered as a human-driven branch of the evolution of natural product structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Rie Kamihira, Yoichi Nakao
Summary: In this study, a probe molecule based on the marine cyclic peptide kapakahine A was prepared to study its interaction with mitochondrial inner membrane proteins.
Review
Chemistry, Applied
Faez Mohammed, Paul Sibley, Dominique Guillaume, Nada Abdulwali
Summary: Maple syrup is a popular natural product known for its sweet taste and desirable flavor, made by boiling and concentrating sap from sugar maple trees. Its chemical composition and mineralogical residence play a key role in determining its distinct flavor, smell, and color, distinguishing it from other sugar syrups. Characterization of maple syrup constituents has been done through various analytical techniques such as spectroscopy and spectrometry, based on over 117 years of published literature.
Review
Pharmacology & Pharmacy
Mihael Cristin Ichim, Anthony Booker
Summary: Chemical methods are crucial for identifying the authenticity of botanical products, with the majority being authentic but a significant proportion found to be adulterated. Varying levels of adulteration were reported across different countries, with the United Kingdom, Italy, the United States, and China reporting different percentages of adulterated products.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Haibo Wang, Yu He, Meiling Jian, Xingang Fu, Yuheng Cheng, Yujia He, Jun Fang, Lin Li, Dan Zhang
Summary: Natural products, with their diverse structures, play significant roles in clinical cancer therapy as nearly 65% of anticancer drugs are either natural products or derivatives. The development of biosynthetic technologies has led to the discovery of an increasing number of natural products used as candidates for clinical cancer therapy.
Article
Chemistry, Multidisciplinary
Yunlong Shi, Ling Fu, Jing Yang, Kate S. Carroll
Summary: This study introduces a chemoselective ligation reaction utilizing Wittig reagents and the unique chemical properties of sulfenic acid, enabling the formation of covalent bonds under biocompatible conditions for protein modification and mitochondrial redox studies.
Article
Multidisciplinary Sciences
Elias Englund, Matthias Schmidt, Alberto A. Nava, Sarah Klass, Leah Keiser, Qingyun Dan, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Summary: Engineering stable variants of polyketide synthases using a solubility biosensor was achieved in this study. The developed biosensor allowed the identification of optimized domain boundaries which maintained wild type production levels. This study successfully provides a high-throughput method for making hybrid polyketide synthases producing novel molecules.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ayesha Fahim, Wan Harun Himratul-Aznita, Puteri Shafinaz Abdul-Rahman, Mohammad K. Alam
Summary: This study evaluated the efficacy of a combination of garlic and bakuchiol against candida virulent genes and their secreted proteins. The combination showed antimicrobial effects on both single and mixed species biofilms. These findings provide insights for alternative treatments for resistant candida infections.
Review
Biochemistry & Molecular Biology
Atsushi Shimoyama, Koichi Fukase
Summary: Researchers suggest that LPS and lipid A play a role in bacterial-host chemical ecology, regulating various host biological phenomena, primarily the immune system. Parasitic and symbiotic bacteria are predicted to have low-toxicity immunomodulators due to co-evolution with the host, leading to structural changes in their LPS.
Article
Multidisciplinary Sciences
Zi Wang, Xujun Zheng, Tetsu Ouchi, Tatiana B. Kouznetsova, Haley K. Beech, Sarah Av-Ron, Takahiro Matsuda, Brandon H. Bowser, Shu Wang, Jeremiah A. Johnson, Julia A. Kalow, Bradley D. Olsen, Jian Ping Gong, Michael Rubinstein, Stephen L. Craig
Summary: This study introduces polymer networks with reactive strand extensions, which significantly improve the stretchability and tear energy of hydrogels. The enhancements synergize with double-network architectures and complement existing toughening strategies.
Review
Biotechnology & Applied Microbiology
Meng Zhang, Liyuan Kong, Rong Gong, Marianna Iorio, Stefano Donadio, Zixin Deng, Margherita Sosio, Wenqing Chen
Summary: This review summarizes recent advances in the biosynthesis of C-nucleoside antibiotics and tentatively discusses future developments in accessing C-nucleoside diversities through synthetic biology strategies.
MICROBIAL CELL FACTORIES
(2022)
Article
Biochemical Research Methods
Rongbin Wang, Jennifer Nguyen, Jacob Hecht, Nora Schwartz, Katelyn Brown, Larissa Ponomareva, Magdalena Niemczura, Dino van Dissel, Gilles P. van Wezel, Jon S. Thorson, Mikko Metsa-Ketela, Khaled A. Shaaban, S. Eric Nybo
Summary: By developing the BIOPOLYMER toolbox, we have overcome the limitations of slow growth and lack of genetic tools in actinomycetes for the synthesis of anthracyclinones. We successfully improved the production host and optimized the production of anthracyclinones, identifying optimal combinations for different molecules. Additionally, we demonstrated the moderate cytotoxicity of the anthracyclinones against multiple cancer cell lines.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Dermatology
Yu Jeong Cho, So-Hyun Nam, Eugene Oh, Michael P. Luciano, Choonghee Lee, Il Hyung Shin, Martin J. Schnermann, Jaepyeong Cha, Kwan Woo Kim
Summary: Bile duct injury during laparoscopic cholecystectomy is a common complication, and identifying bile duct during surgeries remains a challenge. This study demonstrated successful visualization of the biliary tract using a novel fluorescent dye in a swine model, suggesting its potential as a valuable tool for hepato-biliary surgeries.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Harrison C. Daly, Siddharth S. Matikonda, Helena C. Steffens, Bastian Ruehle, Ute Resch-Genger, Joseph Ivanic, Martin J. Schnermann
Summary: The study demonstrates that simple modifications on the xanthene dye scaffold can extend into the SWIR range for deep tissue imaging.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Cell Biology
Raffaella Petruzzelli, Marta Mariniello, Rossella De Cegli, Federico Catalano, Floriana Guida, Elia Di Schiavi, Roman S. Polishchuk
Summary: ATP7B is a key player in the regulation of copper homeostasis and signaling as well as chemoresistance in cancer. This study found that transcription factor EB (TFEB) binds to specific regions of ATP7B, promoting its transcription and contributing to drug resistance in cancer cells.
Article
Biochemical Research Methods
Ek Raj Thapaliya, Syed Muhammad Usama, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St Croix, Martin J. Schnermann
Summary: This study systematically investigates the impact of various functional groups on the properties of antibody-fluorophore conjugates, and suggests that zwitterionic substituents possess an optimal combination of high tumor signal, tumor-to-background ratio, and low liver-to-background ratio.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biochemical Research Methods
Venu G. Bandi, Michael P. Luciano, Mara Saccomano, Nimit L. Patel, Thomas S. Bischof, Jakob G. P. Lingg, Peter T. Tsrunchev, Meredith N. Nix, Bastian Ruehle, Chelsea Sanders, Lisa Riffle, Christina M. Robinson, Simone Difilippantonio, Joseph D. Kalen, Ute Resch-Genger, Joseph Ivanic, Oliver T. Bruns, Martin J. Schnermann
Summary: Through rational design, red-shifted, bioconjugatable heptamethine cyanine dyes were developed for multiplexed in vivo imaging in the shortwave-infrared/near-infrared-II region. The use of wavelengths between 1,000 and 2,000 nm enables high-resolution in vivo imaging at depths not possible with conventional optical wavelengths. Recent progress has shown a lack of bioconjugatable probes for imaging in the shortwave-infrared or near-infrared (NIR)-II range.
Editorial Material
Biochemistry & Molecular Biology
Martin J. Schnermann, Youngjae You
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Oncology
Syed Muhammad Usama, Sierra C. Marker, Servando Hernandez Vargas, Solmaz AghaAmiri, Sukhen C. Ghosh, Naruhiko Ikoma, Hop S. Tran Cao, Martin J. Schnermann, Ali Azhdarinia
Summary: This review provides an overview of the design considerations and fluorescent building blocks of targeted dual-modal imaging agents, as well as potential future directions in this field. Targeted dual-modal imaging agents have the potential to improve surgical workflow, including preoperative patient selection and surgical planning, as well as fluorescence-guided surgery.
Review
Biochemical Research Methods
Siddharth S. Matikonda, Ryan McLaughlin, Pradeep Shrestha, Carol Lipshultz, Martin J. Schnermann
Summary: Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that aim to overcome the limitations of conventional cytotoxic agents. This review describes different ADCs combinations and technologies, with a focus on the anti-HER-2 antibody trastuzumab and its variants.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biophysics
Syed Muhammad Usama, Donald R. Caldwell, Pradeep Shrestha, Michael P. Luciano, Nimit L. Patel, Joseph D. Kalen, Joseph Ivanic, Martin J. Schnermann
Summary: This study details the synthesis and evaluation of a class of norcyanine compounds that enable pH responsive fluorescence imaging in the long wavelength range by installing a hydrophilic substituted quaternary amine, showing promising photophysical properties.
BIOSENSORS & BIOELECTRONICS
(2022)
Retraction
Biochemistry & Molecular Biology
Alessandro Fraldi, Fabio Annunziata, Alessia Lombardi, Hermann-Josef Kaiser, Diego Luis Medina, Carmine Spampanato, Anthony Olind Fedele, Roman Polishchuk, Nicolina Cristina Sorrentino, Kai Simons, Andrea Ballabio
Article
Chemistry, Organic
Quan T. Khong, Donghao Li, Brice A. P. Wilson, Kalina Ranguelova, Masoumeh Dalilian, Emily A. Smith, Antony Wamiru, Ekaterina I. Goncharova, Tanja Grkovic, Donna Voeller, Stanley Lipkowitz, Martin J. Schnermann, Barry R. O'Keefe, Lin Du
Summary: A new dimeric alkaloid, Plakoramine A, was discovered from a marine sponge. It showed potent inhibition of ubiquitin ligase activities. The study also revealed a previously undescribed route to form this compound through photochemical conversion.
Article
Chemistry, Multidisciplinary
Dong-Hao Li, Rananjaya S. Gamage, Allen G. Oliver, Nimit L. Patel, Syed Muhammad Usama, Joseph D. Kalen, Martin J. Schnermann, Bradley D. Smith
Summary: This study reports a synthetic method for producing novel doubly strapped zwitterionic heptamethine cyanine dyes with enhanced stability. These dyes, including a structural analogue of ZW800-1, can be conjugated to proteins, including monoclonal antibodies, without causing fluorophore degradation or dye stacking. The fluorescent antibody conjugates show excellent tumor-targeting specificity in a xenograft mouse tumor model. The enhanced stability provided by the doubly strapped molecular design enables new classes of in vivo NIR fluorescence imaging experiments with possible translation to humans.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Dermatology
Michele S. Saruwatari, Kochai Jawed, Khalid M. Ali, Bo Ning, Sailee Naik, So-Hyun Nam, Martin J. Schnermann, Anthony Sandler, Richard J. Cha
Summary: This study compared the use of BL-760 and ICG for detecting bile leakage during surgery. The results showed that BL-760 could rapidly detect bile leakage with a high fluorescence- to- liver parenchyma ratio, making it a potential tool for identifying bile leakage and duct injury.
LASERS IN SURGERY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Martin J. Schnermann, Luke D. Lavis
Summary: The field of organic chemistry originated in the 19th century with scientists identifying and expanding synthetic dye molecules for textiles. In the 20th century, dye chemistry continued to develop with a focus on creating photographic sensitizers and laser dyes. In the 21st century, the advancement of biological imaging techniques has become a driving force for dye chemistry, especially in the development of rhodamines and cyanines, which are widely used in biological imaging.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Anna C. Love, Donald R. Caldwell, Bethany Kolbaba-Kartchner, Katherine M. Townsend, Lila P. Halbers, Zi Yao, Caroline K. Brennan, Joseph Ivanic, Tanya Hadjian, Jeremy H. Mills, Martin J. Schnermann, Jennifer A. Prescher
Summary: To enable multicomponent bioluminescence imaging in vivo, we developed a new class of near-infrared emitting coumarin luciferin analogues (CouLuc-3s) that can penetrate tissues. These scaffolds were easily synthesized from commercially available dyes. We also identified mutant luciferases that can specifically interact with the CouLuc-3 analogues. The brightest probes allowed for sensitive in vivo imaging. The CouLuc-3 scaffolds are orthogonal to popular bioluminescent reporters, making them suitable for multicomponent imaging applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)