Article
Multidisciplinary Sciences
Christophe Royer, Elizabeth Sandham, Elizabeth Slee, Falk Schneider, Christoffer B. Lagerholm, Jonathan Godwin, Nisha Veits, Holly Hathrell, Felix Zhou, Karolis Leonavicius, Jemma Garratt, Tanaya Narendra, Anna Vincent, Celine Jones, Tim Child, Kevin Coward, Chris Graham, Marco Fritzsche, Xin Lu, Shankar Srinivas
Summary: The study reveals the important role of ASPP2 in maintaining tissue integrity and cytoskeleton organization during development, particularly in regions of high apical tension. This finding has significant implications for understanding morphogenetic events in pseudostratified epithelia and tumor suppression mechanisms.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Feiyun Jiang, Ganxia Bian, Jiehua Li
Summary: This study found that ASPP2 suppresses cell proliferation and promotes apoptosis of cervical cancer cells by inhibiting autophagy. These findings are of significant importance for potential targets in cervical cancer therapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Simona Ferracchiato, Nicola Di-Iacovo, Damiano Scopetti, Danilo Piobbico, Marilena Castelli, Stefania Pieroni, Marco Gargaro, Giorgia Manni, Stefano Brancorsini, Maria Agnese Della-Fazia, Giuseppe Servillo
Summary: The study demonstrated impaired DNA-damage response in Hops heterozygous mice and mouse embryonic fibroblasts, showing reduced levels of p53 protein and apoptotic cells. Additionally, reduced HOPS levels caused deregulation in the transcript profiles of p53-dependent genes. Overall, the results suggest a novel role for Hops as a tumor-suppressor gene in DNA damage repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lindsey Carlsen, Wafik S. El-Deiry
Summary: The TP53 gene, encoding the tumor suppressor protein p53, is mutated in around 50% of cancers. After DNA damage, p53 acts as a transcription factor to activate target genes for cell fates such as apoptosis, cell cycle arrest, and DNA repair. The complex regulatory network controlling target gene selection by p53 varies across contexts such as treatment type, cell type, and tissue type.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shuo Zhou, An Zhao, Yangyang Wu, Tingting Bao, Yuling Mi, Caiqiao Zhang
Summary: Aging in laying hens leads to increased follicular atresia and decreased fecundity, with FSH playing a crucial role in preventing reproductive aging. The study found that FSH can delay the progression of atretic small white follicles in hens by inhibiting DNA damage and promoting repair mechanisms, ultimately protecting granulosa cells from aging-related damage.
Article
Biology
Ananya Chakravarti, Heshani N. Thirimanne, Savanna Brown, Brian R. Calvi
Summary: Using Drosophila as a model, this study found that p53 isoforms in fruit flies have functions specific to DNA damage and cell types, similar to mammalian p53 family members in the genotoxic stress response and oocyte quality control.
Article
Biochemistry & Molecular Biology
Kimiyoshi Yano, Ryou-U Takahashi, Bunsyo Shiotani, Junko Abe, Tomoki Shidooka, Yuki Sudo, Yusuke Yamamoto, Shisei Kan, Hiroki Sakagami, Hidetoshi Tahara
Summary: PRPF19 is identified as a critical regulator of cellular senescence in normal human fibroblasts by modulating MDM4 splicing and p53 activity, leading to induction of p53-dependent cellular senescence.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Ophthalmology
Yan-Kun Yue, Xiao-Li Chen, Shan Liu, Wu Liu
Summary: The study demonstrated that upregulation of ASPP2 expression through lentivirus transfection mitigated the progression of proliferative vitreoretinopathy (PVR) in a rat model, reducing the impact on retinal function and lowering PVR grades. This effect may be attributed to decreased autophagy and attenuated epithelial-mesenchymal transition in the retinas of rats treated with ASPP2-lentivirus, suggesting ASPP2 as a potential new approach for PVR treatment in the future.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cheol Park, Jeong Sook Noh, Youngmi Jung, Sun-Hee Leem, Jin Won Hyun, Young-Chae Chang, Taeg Kyu Kwon, Gi-Young Kim, Hyesook Lee, Yung Hyun Choi
Summary: This study found that fisetin could protect human RPE cells from oxidative stress-induced injury by inhibiting cell damage, DNA damage, and apoptosis. It also improved mitochondrial function and increased the expression and activity of antioxidant enzyme HO-1 through the Nrf2 pathway. The findings suggest that fisetin may have potential therapeutic effects for ocular disorders caused by oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Ulf Smith, Qian Li, Mikael Ryden, Kirsty L. Spalding
Summary: Cell senescence results in irreversible cell cycle arrest and the induction of a senescence-associated secretory phenotype (SASP), impacting cell proliferation and influencing the development of chronic diseases like diabetes and cardiovascular disease. Efforts to target senescent cells using senolytic compounds show promise in improving chronic disorders in experimental animal models.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Review
Cell Biology
Mariantonietta DAmbrosio, Jesus Gil
Summary: Cellular senescence is a stress response associated with aging and disease, including cancer, and plays a complex role in tumor progression and therapy resistance. Senescent cells undergo a stable cell cycle arrest and secrete bioactive molecules known as the senescence-associated secretory phenotype (SASP). While induction of senescence in preneoplastic cells can limit cancer initiation, senescent cells in the tumor microenvironment (TME) can promote tumor progression, metastasis, and therapy resistance. Senotherapies, including senolytic drugs that eliminate senescent cells, have emerged as a potential strategy to impede tumor progression by restoring anti-tumor immune responses and influencing the TME.
DEVELOPMENTAL CELL
(2023)
Article
Cell Biology
Jonathan D. Lee, Bridget L. Menasche, Maria Mavrikaki, Madison M. Uyemura, Su Min Hong, Nina Kozlova, Jin Wei, Mia M. Alfajaro, Renata B. Filler, Arne Muller, Tanvi Saxena, Ryan R. Posey, Priscilla Cheung, Taru Muranen, Yujing J. Heng, Joao A. Paulo, Craig B. Wilen, Frank J. Slack
Summary: COVID-19 caused by SARS-CoV-2 remains a significant public health threat as its variants can evade the immune system and cause breakthrough infections. The impact of pathogenic coronaviruses on chromatin proteomic composition is not well understood. This study reveals that SARS-CoV-2 infection leads to stabilization of TP53 on chromatin, which contributes to its pathogenic effects on host cells. Differences in spike variants of SARS-CoV-2 alter chromatin accessibility, cellular senescence, and inflammatory cytokine release through TP53, suggesting variations in senescence-associated inflammation among different SARS-CoV-2 variants.
Article
Materials Science, Biomaterials
Fei Wei, Craig J. Neal, Tamil Selvan Sakthivel, Sudipta Seal, Thomas Kean, Mehdi Razavi, Melanie Coathup
Summary: Supplementation of CeO nanoparticles at low concentration reduced cell senescence, enhanced cell autophagy, osteogenesis, and bone deposition, while high concentration led to an increase in p53 expression. CeO nanoparticles offer a multifunctional and protective effect against IR-induced cellular damage, as well as promoting osteogenic differentiation and new bone deposition.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biology
Anders Brahme
Summary: This article introduces a new formulation based on recent interaction cross-sections to accurately describe cellular repair, misrepair, and apoptosis. By considering the interaction between mild and complex damage, the formulation significantly improves the method. Based on the mechanisms of repair and misrepair processes, the probability of apoptosis induced by unsuccessful repair processes is described accurately. Low-dose apoptosis is due to incomplete activation of DNA repair. The accurate prediction of apoptosis response is possible through partial misrepair contributions. These findings are important for tumor treatment and a deeper understanding of cellular repair processes.
RADIATION RESEARCH
(2022)
Article
Cell Biology
Yingjie Qing, Hui Li, Yunzi Zhao, Po Hu, Xiangyuan Wang, Xiaoxuan Yu, Mengyuan Zhu, Hongzheng Wang, Zhanyu Wang, Qinglong Guo, Hui Hui
Summary: Wogonin, a natural flavonoid compound, inhibits cell proliferation and induces cellular senescence in T-cell malignancies. It suppresses the transcription activity of hTERT and C-MYC, leading to the inhibition of telomerase activity, and triggers DNA damage in the aging process. Additionally, upregulation of BCL-2 in senescent cells promotes cell survival but can be counteracted by a BCL-2 inhibitor, Navitoclax, enhancing sensitivity to apoptotic cell death.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih, Marcus Matthias Schittenhelm
Article
Oncology
Kerstin Maria Kampa-Schittenhelm, Julia Frey, Lara A. Haeusser, Barbara Illing, Ashly A. Pavlovsky, Gunnar Blumenstock, Marcus Matthias Schittenhelm
Article
Biochemistry & Molecular Biology
Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Katharina Henriette Rasp, Barbara Illing, Hartmut Doehner, Konstanze Doehner, Marcus Matthias Schittenhelm
Article
Biochemistry & Molecular Biology
Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Hartmut Doehner, Konstanze Doehner, Marcus Matthias Schittenhelm
Article
Multidisciplinary Sciences
Marcus M. Schittenhelm, Barbara Illing, Figen Ahmut, Katharina Henriette Rasp, Gunnar Blumenstock, Konstanze Doehner, Charles D. Lopez, Kerstin M. Kampa-Schittenhelm
Article
Oncology
Matthew R. Kearney, Emerson Y. Chen, Gina M. Vaccaro, John Strother, Andrea Burt, Kendra Todd, Jeff Donovan, Kerstin M. Kampa-Schittenhelm, Charles D. Lopez
ANTICANCER RESEARCH
(2019)
Article
Medicine, General & Internal
Marcus Matthias Schittenhelm, Bianca Walter, Vasileia Tsintari, Birgit Federmann, Mihada Bajrami Saipi, Figen Akmut, Barbara Illing, Ulrike Mau-Holzmann, Falko Fend, Charles Darin Lopez, Kerstin Maria Kampa-Schittenhelm
Article
Medicine, General & Internal
K. M. Kampa-Schittenhelm, T. Haverkamp, M. Bonin, V Tsintari, H. J. Buehring, L. Haeusser, G. Blumenstock, S. T. Dreher, T. Ganief, F. Akmut, B. Illing, U. A. Mau-Holzmann, I Bonzheim, E. Schleicher, W. Vogel, M. M. Schittenhelm
Article
Medicine, General & Internal
Johannes Kliebhan, Andrej Besse, Kerstin Kampa-Schittenhelm, Marcus Schittenhelm, Christoph Driessen
Summary: The p53_R273H mutation leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth in tumor cells. We present a case of mantle cell lymphoma with this mutation, characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.
CLINICAL CASE REPORTS
(2022)
Meeting Abstract
Hematology
Marcus M. Schittenhelm, Max Kaiser, Gunnar Blumenstock, Kerstin Maria Kampa-Schittenhelm
Meeting Abstract
Hematology
Kerstin Maria Kampa-Schittenhelm, Ulrike Mau-Holzmann, Charles Lopez, Marcus M. Schittenhelm
Meeting Abstract
Hematology
Kerstin Maria Kampa-Schittenhelm, Hans-Joerg Buehring, Michael Bonin, Wichard Vogel, Lothar Kanz, Thomas Haverkamp, Marcus M. Schittenhelm
Meeting Abstract
Hematology
Marcus M. Schittenhelm, Figen Akmut, Barbara Illing, Julia Frey, Katja Schuster, Abhijit Ramachandran, Lothar Kanz, Kerstin M. Kampa-Schittenhelm
Meeting Abstract
Hematology
Kerstin M. Kampa-Schittenhelm, Figen Akmut, Barbara Illing, Charles Lopez, Marcus M. Schittenhelm
Meeting Abstract
Hematology
Kerstin M. Kampa-Schittenhelm, Barbara Illing, Figen Akmut, Michael Walter, Charles D. Lopez, Marcus M. Schittenhelm