Article
Multidisciplinary Sciences
Joon Seo Lim, Cheolwon Moon, Junyeop Lee
Summary: The presence of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC) is associated with disturbances in retinal blood flow, including reduced venous blood flow velocity and rate, as well as changes in venous diameter. SRF thickness is correlated with a decrease in venous blood flow rate, suggesting that SRF plays a role in altering retinal blood flow dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Akika Kyo, Manabu Yamamoto, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Shigeru Honda
Summary: This study investigated the factors influencing the clinical outcome of SRT for CSC, finding that the rate of change in CMT was associated with focal leakage type on FA and baseline CMT, while complete resolution of subretinal fluid was associated with non-smoking history and focal leakage type on FA. These findings may help predict the therapeutic effectiveness of SRT.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Biotechnology & Applied Microbiology
Fabao Xu, Shaopeng Liu, Yifan Xiang, Zhenzhe Lin, Cong Li, Lijun Zhou, Yajun Gong, Longhui Li, Zhongwen Li, Chong Guo, Chuangxin Huang, Kunbei Lai, Hongkun Zhao, Jiaming Hong, Haotian Lin, Chenjin Jin
Summary: The study developed a cascaded deep learning system based on fundus image for automated SRF detection and macula-on/off serous retinal detachment discerning. The system's performance is reliable, with higher accuracy of SRF detection than experienced retinal specialists, and it can automatically indicate whether SRF progression involves the macula to provide urgent guidance for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Takahiro Kogo, Yuki Muraoka, Masaharu Ishikura, Naomi Nishigori, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: The purpose of this study was to investigate choroidal angiographic features associated with the resolution or persistency of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC). The study found that vertically asymmetric dilation of choroidal vessels in the posterior pole may be a good predictor of future SRF status.
Article
Ophthalmology
Sumit Randhir Singh, Claudio Iovino, Dinah Zur, Dua Masarwa, Matias Iglicki, Ramkailash Gujar, Marco Lupidi, Dmitrii S. Maltsev, Elodie Bousquet, Mehdi Bencheqroun, Francesca Amoroso, Luiz H. Lima, Srikanta Kumar Padhy, Vishal Govindahari, Khushboo Chandra, Eric H. Souied, Francisco J. Rodriguez, Laura A. Daza, Hernan A. Rios, Carlo Cagini, Enrico Peiretti, Francine Behar-Cohen, Jay Chhablani
Summary: This study aimed to identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR). The results showed that factors such as central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ), and interdigitation zone damage on optical coherence tomography (OCT) were predictive of anatomical and visual outcomes in CSCR eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Joost Brinks, Femke M. van Haalen, Thomas J. van Rijssen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira, Camiel J. F. Boon, Elon H. C. van Dijk
Summary: The study found that ocular abnormalities resembling (subclinical) central serous chorioretinopathy (CSC) are more common than previously thought in patients with active Cushing's syndrome (CS), and may even exist in patients without visual complaints. Early treatment may be necessary to prevent vision loss in these patients.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Ophthalmology
Supriya Arora, Baldassarre D. Stea, Russell J. Hamilton, Jay Chhablani
Summary: Low dose radiation can be used in refractory cases of central serous chorioretinopathy (CSCR) to decrease the hyperpermeability of large choroidal vessels.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Amee D. Azad, Maggie Zhou, Armin R. Afshar, Sophie J. Bakri, Suzann Pershing
Summary: This study analyzed the frequency of systemic corticosteroid prescriptions before and after CSC diagnosis and found that many patients continue to be prescribed steroids after CSC diagnosis. The results suggest a need for greater communication and collaboration among providers to ensure that clinical practice reflects evidence-based recommendations.
Article
Oncology
Fabao Xu, Yifan Xiang, Cheng Wan, Qijing You, Lijun Zhou, Cong Li, Songjian Gong, Yajun Gong, Longhui Li, Zhongwen Li, Li Zhang, Xiayin Zhang, Chong Guo, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Chenjin Jin, Haotian Lin
Summary: The study used machine learning to predict subretinal fluid absorption (SFA) in patients with CSC after laser treatment, finding that random forest and XGBoost performed best in prediction. The simplified model also showed a comparable level of predictive power.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Seigo Yoneyama, Ayumi Fukui, Yoichi Sakurada, Nobuhiro Terao, Taiyo Shijo, Natsuki Kusada, Atsushi Sugiyama, Mio Matsubara, Yoshiko Fukuda, Wataru Kikushima, Ravi Parikh, Fumihiko Mabuchi, Chie Sotozono, Kenji Kashiwagi
Summary: This study investigated the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC), finding significant age differences, subfoveal choroidal thickness variations, and central retinal thickness disparities, as well as differences in the frequency of a descending tract between genders.
SCIENTIFIC REPORTS
(2022)