Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

(2013) X Song et al.   Cell Death & Disease

Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1

(2012) Bo Ram Seo et al.   BIOCHIMIE

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer

(2012) Chen Liu et al.   MOLECULAR BIOLOGY REPORTS

The Role of Bcl-xL in Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia on Human Colon Cancer

(2012) X. Song et al.   MOLECULAR CANCER RESEARCH

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

Prognostic significance of Bcl-xL gene expression in human colorectal cancer

(2011) Yang Jin-Song et al.   ACTA HISTOCHEMICA

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Targeting Trail Towards the Clinic

(2011) Devalingam Mahalingam et al.   CURRENT DRUG TARGETS

Oxaliplatin Sensitizes Human Colon Cancer Cells to TRAIL Through JNK-Dependent Phosphorylation of Bcl-xL

(2011) Zineb El Fajoui et al.   GASTROENTEROLOGY

The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells

(2011) L. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

Isolated Hepatic Perfusion with High-Dose Melphalan Results in Immediate Alterations in Tumor Gene Expression in Patients with Metastatic Ocular Melanoma

(2010) Sheelu Varghese et al.   ANNALS OF SURGICAL ONCOLOGY

A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma

(2010) A Younes et al.   BRITISH JOURNAL OF CANCER

Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer

(2010) T Trarbach et al.   BRITISH JOURNAL OF CANCER

Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors

(2010) Marco A. Alcala et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mapatumumab, a Fully Human Agonistic Monoclonal Antibody That Targets TRAIL-R1, in Combination with Gemcitabine and Cisplatin: a Phase I Study

(2009) C. H. Mom et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Hyperthermic Isolated Hepatic Perfusion with Oxaliplatin in the Treatment of Unresectable Liver Metastases from Colorectal Cancer

(2008) Herbert J. Zeh et al.   ANNALS OF SURGICAL ONCOLOGY

A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer

(2008) C. Odoux et al.   CANCER RESEARCH

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy

(2008) Ahmad Safa et al.   CURRENT CANCER DRUG TARGETS

Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance

(2008) Meenakshi Upreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer

(2008) F. Anthony Greco et al.   LUNG CANCER

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

FLIP and the death effector domain family

(2008) J W Yu et al.   ONCOGENE

Significance of Bcl-xL in human colon carcinoma

(2008) You-Li Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY