Article
Microbiology
James T. Van Leuven, Andres J. Gonzalez, Emmanuel C. Ijezie, Alexander Q. Wixom, John L. Clary, Maricris N. Naranjo, Benjamin J. Ridenhour, Craig R. Miller, Tanya A. Miura
Summary: Coinfection by heterologous respiratory viruses can alter disease severity and a mild upper respiratory viral infection can reduce the severity of a subsequent severe viral infection in the lungs through virus-dependent mechanisms.
Article
Biochemistry & Molecular Biology
Anita Singh, Sara Busacca, Aarti Gaba, Michael Sheaff, Charlotte Poile, Apostolos Nakas, Joanna Dzialo, Aleksandra Bzura, Alan G. G. Dawson, Dean A. A. Fennell, Andrew M. M. Fry
Summary: This study identifies the tumour suppressor gene BAP1 as frequently mutated in mesothelioma and reveals novel functions for BAP1 in mitotic progression, highlighting its role in genome stability control with therapeutic implications. Depletion of BAP1 leads to proteasome-mediated degradation of BRCA1, mitotic defects similar to BRCA1 loss, and additional changes including abnormal spindle length and enhanced growth of astral microtubules. These consequences are explained by the loss of KIF18A and KIF18B expression, which can be rescued by their re-expression. Therefore, inactivation of BAP1 causes mitotic defects through both BRCA1-dependent and independent mechanisms, suggesting new pathways for genome instability and altered response to microtubule-targeted agents in BAP1-deficient mesothelioma cells.
Article
Biochemistry & Molecular Biology
Chiara Pastorio, Sara Torres-Rusillo, Juan Ortega-Vidal, M. Carmen Jimenez-Lopez, Inmaculada Ianez, Sofia Salido, Manuel Santamaria, Joaquin Altarejos, Ignacio J. Molina
Summary: Olive oil contains (-)-oleocanthal (OLC), which has been found to have anti-inflammatory, antioxidant, and antitumor activities. This study examined the effects of OLC on various cell lines and found that it inhibits cell proliferation and induces apoptotic death. Hematopoietic tumor cell lines were the most sensitive to OLC treatment. The mechanisms of OLC-mediated cell death involve caspase-dependent and independent pathways.
Article
Cell Biology
Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Lim
Summary: High-frequency stimulation (HFS) is a promising therapy for depression, and this study investigated the dopamine-dependent mechanism of the antidepressant-like effects of HFS of the prelimbic cortex (HFS PrL). The results showed that HFS PrL significantly increased hedonia, reduced anxiety, decreased forced swim immobility, and enhanced hippocampal dopamine and serotonin levels.
Article
Biochemistry & Molecular Biology
Tobias Mechelke, Felix Wittig, Robert Ramer, Burkhard Hinz
Summary: The study found that IL-1 beta induces TF expression in lung cancer cells through multiple signaling pathways, including EGFR and MAPK pathways. Inhibition of EGFR can reduce TF expression and suppress the activation of p42/44 MAPK and EGFR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Balint Viktor Lovasz, Gergely Berta, Edina Lempel, Gyorgy Setalo, Monika Vecsernyes, Jozsef Szalma
Summary: The study suggests that relevant concentrations of TEGDMA monomers leached from resin-based composite materials (RBCs) induce apoptosis in pulp cells through both caspase-dependent and caspase-independent mechanisms, possibly involving endoplasmic reticulum stress and the activation of caspase-independent apoptotic pathways.
Article
Oncology
Xinyu Zhou, Abel Soto-Gamez, Fleur Nijdam, Rita Setroikromo, Wim J. Quax
Summary: Combining transferrin and dihydroartemisinin enhances cell death in triple-negative breast cancer cells induced by TRAIL. This combination therapy triggers more cell death by increasing DR5 expression in sensitive cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roberto Amigo, Fernanda Raiqueo, Estefania Tarifeno, Carlos Farkas, Jose L. Gutierrez
Summary: The establishment and maintenance of nucleosome-free regions (NFRs) are essential processes in chromatin dynamics. This study investigates the role of transcription factors, chromatin remodeling complexes, and DNA sequences, particularly poly(dA:dT) tracts, in nucleosome remodeling. The results show that poly(dA:dT) tracts have differential effects on the activity of chromatin remodeling complexes and affect the directionality of nucleosome sliding. These findings shed light on the mechanisms underlying asymmetrical chromatin opening around poly(dA:dT) tracts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bader Hasan, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
Summary: This study investigated the effects of modifications around the porphyrin ring on the anticancer activity of MnPs-based SOD mimics. It was found that compounds with appropriate reduction potentials act via a ROS-dependent mechanism, while amphiphilic MnPs exert anticancer activity by damaging cellular structures. Designing compounds that interact with sensitive cellular targets shows promise in the development of selective and specific anticancer drugs.
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Oncology
Maja S. Misirkic Marjanovic, Ljubica M. Vucicevic, Ana R. Despotovic, Marina M. Stamenkovic, Kristina D. Janjetovic
Summary: Metformin, a widely used antidiabetic drug, has recently been discovered to possess anticancer potential due to its ability to target multiple pathways important for cancer cell survival. Understanding the molecular regulatory networks in cancer can help simplify the application of metformin in clinical trials and improve anti-cancer therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Immunology
Eric J. Gapud, Maria Isabel Trejo-Zambrano, Eduardo Gomez-Banuelos, Eleni Tiniakou, Brendan Antiochos, David J. Granville, Felipe Andrade, Livia Casciola-Rosen, Antony Rosen
Summary: This study unveils a range of novel signaling activities of Granzyme B that do not require perforin, occur intracellularly, and are not associated with cell death, which could have mechanistic implications for human diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rafael Gonzalez-Cano, Angeles Montilla-Garcia, Gloria Perazzoli, Jesus M. Torres, Francisco J. Canizares, Eduardo Fernandez-Segura, Michael Costigan, Jose M. Baeyens, Enrique J. Cobos
Summary: Both TRPA1 and purinergic P2X receptors are proposed as potential targets for the treatment of visceral pain. While a low dose of mustard oil induces visceral pain dependent on TRPA1, a higher dose results in pain mostly independent of TRPA1 but enhanced by ATP released from damaged tissues. Thus, TRPA1 inhibition may not be sufficient to decrease visceral pain significantly during tissue injury, and purinergic antagonism appears to be a more effective strategy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Lara Rouco, Angeles Sanchez-Gonzalez, Rebeca Alvarino, Amparo Alfonso, Ezequiel M. Vazquez-Lopez, Emilia Garcia-Martinez, Marcelino Maneiro
Summary: In this study, two benzimidazole gold(I) derivatives were synthesized and tested for their cytotoxicity in human neuroblastoma cells. The compounds showed antiproliferative effects through oxidative stress mediated mechanisms involving both caspase-dependent and caspase-independent pathways.
Article
Pharmacology & Pharmacy
Zi-Xuan Wang, Jing Ma, Xin-Yu Li, Yong Wu, Huan Shi, Yao Chen, Guang Lu, Han-Ming Shen, Guo-Dong Lu, Jing Zhou
Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Sanghyun Lee, Gowri Kalugotla, Harshad Ingle, Rachel Rodgers, Chunyan Wu, Yating Wang, Yuhao Li, Xia Yang, Jin Zhang, Nicolette R. Borella, Hongju Deng, Lindsay Droit, Ryan Hill, Stefan T. Peterson, Chandni Desai, Dylan Lawrence, Qun Lu, Megan T. Baldridge
Summary: Mutations in the autophagy gene EPG5 lead to protection against multiple enteric viruses in mice, primarily through modulation of intestinal IFNλ responses, independent of microbiota influence.
Article
Virology
Periyasamy Vijayakumar, Ashwin Ashok Raut, Santhalembi Chingtham, Harshad Murugkar, Diwakar D. Kulkarni, Richa Sood, Vijendra Pal Singh, Anamika Mishra
Summary: Proteomic analysis of chicken lung infected with HPAI H5N1 virus identified signaling pathways and proteins associated with disease pathogenesis, including Toll-like receptors, RLRs, NLRs, and JAK-STAT signaling. Activation of these pathways may lead to cytokine storm effect and severity of HPAI H5N1 infection in chickens.
ARCHIVES OF VIROLOGY
(2022)
Article
Biology
Jacob A. Van Winkle, Stefan T. Peterson, Elizabeth A. Kennedy, Michael J. Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A. Constant, Austin P. Wright, Lena Li, Maxim N. Artyomov, Sanghyun Lee, Megan T. Baldridge, Timothy J. Nice
Summary: Bacterial microbiota stimulate the expression of antiviral genes in intestinal epithelial cells, enhancing host defense against enteric viruses.
Article
Cell Biology
Ashish Kumar, Yuanzhi Lyu, Yuichi Yanagihashi, Chanikarn Chantarasrivong, Vladimir Majerciak, Michelle Salemi, Kang-Hsin Wang, Tomoki Inagaki, Frank Chuang, Ryan R. Davis, Clifford G. Tepper, Kazushi Nakano, Chie Izumiya, Michiko Shimoda, Ken-ichi Nakajima, Alexander Merleev, Zhi-Ming Zheng, Mel Campbell, Yoshihiro Izumiya
Summary: This study reveals the nuclear microenvironment of Kaposi sarcoma-associated herpesvirus (KSHV) and its role in regulating the latency-lytic replication switch. Viral long non-coding RNAs interact with CHD4 to control KSHV reactivation.
Article
Oncology
Sumana Paul, Saikat Ghosh, Sushil Kumar
Summary: Cancer cells undergo metabolic alterations to meet energy demands, with glycolysis playing a central role. Glycolysis is intertwined with other metabolic pathways, leading to diverse and heterogeneous cancer metabolism. Oncogenic signaling enhances glycolytic enzyme activity, promoting tumor growth and metastasis. This article discusses the interactions between tumor glycolysis and other metabolic pathways, the role and regulation of key enzymes, and the significance of lactate in tumor growth and metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Immunology
Katrina M. Morris, Anamika Mishra, Ashwin A. Raut, Eleanor R. Gaunt, Dominika Borowska, Richard I. Kuo, Bo Wang, Periyasamy Vijayakumar, Santhalembi Chingtham, Rupam Dutta, Kenneth Baillie, Paul Digard, Lonneke Vervelde, David W. Burt, Jacqueline Smith
Summary: Highly pathogenic avian influenza (HPAI) viruses, such as H5N1, pose a serious threat to animal agriculture, wildlife, and public health. This study aimed to understand the susceptibility and tolerance of different avian species to HPAI challenge by examining the response of six species to low pathogenic avian influenza (H9N2) and two strains of H5N1 with differing virulence. The study revealed important discoveries regarding the viral loads, neuro-inflammatory response, differential gene regulation, and immune response timing in different avian species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Danielle E. Campbell, Yuhao Li, Harshad Ingle, Megan T. Baldridge
Summary: This review discusses the influence of the gastrointestinal microbiota on viral infection, highlighting the involvement of gut microbes and their metabolites in regulating the course of viral infections through various mechanisms.
ANNUAL REVIEW OF VIROLOGY
(2023)
Letter
Oncology
Ranjeet Singh Mahla
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Letter
Medicine, General & Internal
R. S. Mahla
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Rheumatology
Ranjeet Singh Mahla
Letter
Rheumatology
Ranjeet Singh Mahla
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Ranjeet Singh Mahla
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Harshad Ingle, Heyde Makimaa, Somya Aggarwal, Hongju Deng, Lynne Foster, Yuhao Li, Elizabeth A. Kennedy, Stefan T. Peterson, Craig B. Wilen, Sanghyun Lee, Mehul S. Suthar, Megan T. Baldridge
Summary: This study demonstrates that interferon-lambda (IFN-lambda) can limit the infection of norovirus (MNoV) in tuft cells, and noninfected cells serve as the source of IFN-lambda.
Letter
Virology
Anamika Mishra, Muhasin Asaf, Amod Kumar, Diwakar Dattatreya Kulkarni, Richa Sood, Sandeep Bhatia, Bharat Bhushan, Ashwin Ashok Raut
Article
Medicine, Research & Experimental
Ranjeet Singh Mahla, Lynn B. Dustin
Summary: A major goal of SARS-CoV-2 vaccination is to induce the production of neutralizing antibodies that can block viral infection. Despite the rapid evolution of the virus, researchers have identified mutation-resistant neutralizing antibodies using yeast display libraries, which is of great importance for the development of better therapeutics.
JOURNAL OF CLINICAL INVESTIGATION
(2022)