Article
Biochemistry & Molecular Biology
Terry C. Yin, Ayushi Mittal, Paul Buscaglia, Wenxian Li, Julien A. Sebag
Summary: Energy homeostasis is a complex system involving multiple hormones, neuropeptides, and receptors. Prokineticins (PK1 and PK2) are agonists to two G protein-coupled receptors, prokineticin receptor 1 and 2 (PKR1 and PKR2), which decrease food intake when injected in rodents. This study investigates the relative contribution of PKR1 and PKR2 to the anorexigenic effect of PK2, as well as their site of action in the brain, and the role of MRAP2 in modulating PK2 activity. The results demonstrate that the anorexigenic effect of PK2 is mediated by PKR2 in the amygdala and that MRAP2 can alter PK2 activity in PKR2 neurons.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Camila Oliveira de Souza, Xuenan Sun, Dayoung Oh
Summary: Seven transmembrane receptors, also known as G protein-coupled receptors, are common targets for therapeutic drugs. Studies suggest that different members of the GPCR superfamily may be potential targets for treating metabolic disorders like obesity and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Tadashi Nakagawa, Toru Hosoi
Summary: Organismal energy balance is regulated by inter-tissue communication mediated by the nervous system and hormones. Leptin, secreted by fat-storing adipose tissue, plays a key role in inhibiting fat accumulation and promoting energy expenditure. Understanding the synthesis, transportation, and excretion of leptin is crucial for maintaining blood leptin concentration and may provide therapeutic strategies for obesity and related metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akari Nishida, Junki Miyamoto, Hidenori Shimizu, Ikuo Kimura
Summary: The study found that the SCFA receptor Olfr78 is highly expressed in the colon and enteroendocrine cells, and can promote the secretion of anorexigenic gut hormone PYY through SCFAs such as acetate, playing a crucial role in anti-obesity and anorexigenic effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Roberta Lattanzi, Rossella Miele
Summary: Melanocortin Receptor Accessory Protein 2 (MRAP2) regulates the trafficking and signal transduction of G-protein-coupled receptors (GPCRs) involved in energy homeostasis, and its interaction with PKR2 plays a crucial role in modulating receptor localization and signaling. The prokineticin transduction system also regulates MRAP2 expression, highlighting its importance in the control of food intake.
Review
Pharmacology & Pharmacy
Patricio Atanes, Tanyel Ashik, Shanta J. Persaud
Summary: This study compared the expression of GPCR mRNA in human islets obtained from donors with normal weight range and those classified as obese. The altered expression of GPCRs in obesity may have an impact on islet function, and the study also considered the possible effects of adipokines on GPCRs showing altered expression in obesity.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Fabiane Ferreira Martins, Thiago Santos-Reis, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: The aim of this study was to examine the effects of semaglutide on neuropeptide signaling in the hypothalamic energy metabolism of diet-induced obese mice. The results showed that semaglutide improved leptin sensitivity and anorexigenic signaling, while decreasing orexigenic signaling. Furthermore, semaglutide also affected biometric data and hypothalamic gene expressions. Therefore, semaglutide can activate anorexigenic signaling by restoring leptin, amylin, and POMC pathways in diet-induced obese mice.
Article
Multidisciplinary Sciences
Ewelina Goryszewska-Szczurek, Monika Baryla, Piotr Kaczynski, Agnieszka Waclawik
Summary: Prokineticin 1 plays a pleiotropic role in trophoblast function during implantation and early placentation, with its signaling pathway regulating key functions such as cell proliferation and adhesion. The study also identified the involvement of various signaling pathways, including MAPK, PI3K/AKT/mTOR, and cAMP, in mediating the effects of PROK1 in trophoblasts. The findings suggest that PROK1 has a significant impact on trophoblast development and function in the early stages of pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Veronica Murcia-Belmonte, Maria Tercero-Diaz, Diego Barrasa-Martin, Sandra Lopez de la Vieja, Marina Munoz-Lopez, Pedro F. Esteban
Summary: The X-linked form of Kallmann syndrome is caused by mutations in the ANOS1 gene, resulting in hypogonadotropic hypogonadism and anosmia. This study reveals that anosmin 1 can enhance the activation of the PK2/PKR2 pathway and modulate its biological effects. The N-terminal region of anosmin 1 interacts with PKR2, and the whey acidic protein domain is necessary for this modulatory activity, while the cysteine-rich and FnIII.1 domains may assist in binding to PKR2 and regulating receptor activation by PK2.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Roberta Lattanzi, Cinzia Severini, Rossella Miele
Summary: Inflammation plays a crucial role in tumor progression. Prokineticin 2 is involved in tumor growth, angiogenesis, and metastasis. In addition to its function as an angiogenic factor and a mediator of immune cell migration, prokineticin 2 also suppresses tumor cell apoptosis, promotes their proliferation and movements necessary for metastasis. It is also associated with tumor pain and resistance responses, and may serve as a potential prognostic tumor biomarker.
Review
Biochemistry & Molecular Biology
Carla Petrella, Matteo Spaziani, Valerio D'Orazi, Luigi Tarani, Sergio Terracina, Francesca Tarani, Ginevra Micangeli, Christian Barbato, Antonio Minni, Antonio Greco, Andrea M. Isidori, Giampiero Ferraguti, Marco Fiore
Summary: Male infertility accounts for about 50% of infertility in couples, with the diagnosis and treatment process being crucial in understanding the biological origins of infertility and potential therapeutic interventions. The prokineticin system, particularly PROK2, plays a significant role in male infertility by offering new insights into testicular pathophysiology and potential therapeutic hypotheses.
Review
Biochemistry & Molecular Biology
Alessia Dallatana, Linda Cremonesi, Maddalena Trombetta, Giulio Fracasso, Riccardo Nocini, Luca Giacomello, Giulio Innamorati
Summary: The human genome contains multiple GPCRs specialized in sensing various extracellular cues, including light, odorants, nutrients, and hormones. These GPCRs play a crucial role in regulating glucose homeostasis, especially for beta cells. The rise of type 2 diabetes in pediatric age may be due to changes in lifestyle and hormonal balance, highlighting the need for tailored treatments for young patients.
Review
Cell Biology
Aiqi Yin, Xiaonian Guan, Jian Zhang, Jianmin Niu
Summary: Preeclampsia is a clinical syndrome characterized by hypertension and proteinuria, and its etiology and pathogenesis are not fully understood. Obesity, immunological diseases, and endocrine metabolic diseases are high-risk factors for preeclampsia. The pathogenesis of preeclampsia involves poor placentation, uteroplacental malperfusion, oxidative stress, immune tolerance dysregulation, vascular inflammation, and endothelial cell dysfunction. The placenta is considered a core factor in the pathogenesis of preeclampsia. G protein-coupled receptors, specifically the secretin/adhesion (Class B) receptors, have potential roles as drug targets in placental development and preeclampsia treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Lauren Patterson Cobb, Sharareh Siamakpour-Reihani, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Chunxiao Zhou, Thomas P. Conrads, G. Larry Maxwell, Kathleen M. Darcy, Nicholas W. Bateman, Tracy Litzi, Victoria Bae-Jump, Angeles Alvarez Secord
Summary: This study evaluated the association between obesity and angiogenic-related gene expression in endometrial cancer, showing that a high-fat diet led to increased Edil3 expression in mice. The interaction between diet and metformin on Edil3 expression was observed, suggesting the potential role of EDIL3 as a candidate gene of interest in tumor progression.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Cell Biology
Chuanjun Shu, Can Wang, Saisai Chen, Xuan Huang, Jiahua Cui, Wenchao Li, Bin Xu
Summary: Enhancer release and retargeting (ERR) events activate GPR35 in gastric cancer cells, promoting proliferation, migration, and immune cell exhaustion and infiltration. High GPR35 expression is associated with poor prognosis in gastric cancer patients.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Medicinal
Amel Djehal, Mohammad Krayem, Ahmad Najem, Hassan Hammoud, Thierry Cresteil, Canan G. Nebigil, Dong Wang, Peng Yu, Embarek Bentouhami, Ghanem E. Ghanem, Laurent Desaubry
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Cell & Tissue Engineering
Rehana Qureshi, Michel Kindo, Mounia Boulberdaa, Jean-Jacques von Hunolstein, Marja Steenman, Canan G. Nebigil
Article
Cardiac & Cardiovascular Systems
Canan G. Nebigil, Laurent Desaubry
TRENDS IN CARDIOVASCULAR MEDICINE
(2019)
Review
Pharmacology & Pharmacy
Canan G. Nebigil, Laurent Desaubry
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Chemistry, Medicinal
Sabria Elderwish, Anais Audebrand, Canan G. Nebigil, Laurent Desaubry
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil, Laurent Desaubry
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Chemistry, Medicinal
Canan G. Nebigil, Christiane Moog, Stephan Vagner, Nadia Benkirane-Jessel, Duncan R. Smith, Laurent Desaubry
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Laurent Desaubry, Anumantha G. Kanthasamy, Canan G. Nebigil
PHARMACOLOGICAL RESEARCH
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Canan G. Nebigil, Michael W. Y. Chan, Tienush Rassaf
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Peripheral Vascular Disease
Ferda Demir, Kyoji Urayama, Anais Audebrand, Ayca Toprak-Semiz, Marja Steenman, Hitoshi Kurose, Canan G. Nebigil
Summary: This study reveals that pressure overload-mediated PKR2 signaling in cardiomyocytes contributes to cardiac hypertrophy through autocrine signaling, and vascular rarefaction via cardiac cytokine-mediated cardiomyocyte-endothelial cell communications. Our results may contribute to the development of potential therapeutic targets for heart failure.
Correction
Developmental Biology
Thu Lan Nguyen, Adeline Gasser, Canan G. Nebigil
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2020)
Article
Chemistry, Medicinal
Dong Wang, Redouane Tabti, Sabria Elderwish, Amel Djehal, Nora Chouha, Franck Pinot, Peng Yu, Canan G. Nebigil, Laurent Desaubry
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Cardiac & Cardiovascular Systems
Anais Audebrand, Laurent Desaubry, Canan G. Nebigil
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Oncology
Adeline Gasser, Yu-Wen Chen, Anais Audebrand, Ayhan Daglayan, Marine Charavin, Brigitte Escoubet, Pavel Karpov, Igor Tetko, Michael W. Y. Chan, Daniela Cardinale, Laurent Desaubry, Canan G. Nebigil
JACC: CARDIOONCOLOGY
(2019)
Article
Pharmacology & Pharmacy
C. G. Nebigil, L. Desaubry
ANNALES PHARMACEUTIQUES FRANCAISES
(2018)