Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling
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Title
Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling
Authors
Keywords
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Journal
PLoS One
Volume 13, Issue 10, Pages e0206232
Publisher
Public Library of Science (PLoS)
Online
2018-10-25
DOI
10.1371/journal.pone.0206232
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- (2016) Jennifer A. Rohrs et al. Cellular and Molecular Bioengineering
- Immune-related adverse events with immune checkpoint blockade: a comprehensive review
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- (2016) Sabrina Jutz et al. JOURNAL OF IMMUNOLOGICAL METHODS
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- (2016) Alexander P. R. Bally et al. JOURNAL OF IMMUNOLOGY
- PD-L1 expression in human cancers and its association with clinical outcomes
- (2016) Jinming Yu et al. OncoTargets and Therapy
- A Stochastic Model of the Yeast Cell Cycle Reveals Roles for Feedback Regulation in Limiting Cellular Variability
- (2016) Debashis Barik et al. PLoS Computational Biology
- IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer
- (2015) K Abiko et al. BRITISH JOURNAL OF CANCER
- Human PD-1 binds differently to its human ligands: A comprehensive modeling study
- (2015) Clement Viricel et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy
- (2015) S. P. Patel et al. MOLECULAR CANCER THERAPEUTICS
- T cell receptor dwell times control the kinase activity of Zap70
- (2015) Christian Klammt et al. NATURE IMMUNOLOGY
- Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
- (2015) D. Fey et al. Science Signaling
- T-cell exhaustion in the tumor microenvironment
- (2015) Y Jiang et al. Cell Death & Disease
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- (2015) Nikolaos Patsoukis et al. Nature Communications
- Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
- (2015) D. Fey et al. Science Signaling
- Immune Escape Mechanisms as a Guide for Cancer Immunotherapy
- (2014) G. L. Beatty et al. CLINICAL CANCER RESEARCH
- Insights into the initiation of TCR signaling
- (2014) Arup K Chakraborty et al. NATURE IMMUNOLOGY
- In vitro membrane reconstitution of the T-cell receptor proximal signaling network
- (2014) Enfu Hui et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks
- (2014) Karen E Tkach et al. eLife
- Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition
- (2013) Xiao-Jun Tian et al. BIOPHYSICAL JOURNAL
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- PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
- (2013) Bernd H. Zinselmeyer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
- (2013) P. Francois et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Strength of PD-1 signaling differentially affects T-cell effector functions
- (2013) F. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity
- (2013) N. Miskov-Zivanov et al. Science Signaling
- Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common Chain Cytokines in T Cells
- (2013) J. W. Cotari et al. Science Signaling
- Tolerance and exhaustion: defining mechanisms of T cell dysfunction
- (2013) Andrea Schietinger et al. TRENDS IN IMMUNOLOGY
- Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
- (2012) N. Patsoukis et al. Science Signaling
- Interplay between gene expression noise and regulatory network architecture
- (2012) Guilhem Chalancon et al. TRENDS IN GENETICS
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- A Mathematical Model for the Reciprocal Differentiation of T Helper 17 Cells and Induced Regulatory T Cells
- (2011) Tian Hong et al. PLoS Computational Biology
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- (2010) John J. Tyson et al. Annual Review of Physical Chemistry
- Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
- (2010) Konstantina Nika et al. IMMUNITY
- Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
- (2010) D. Busse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biological role of noise encoded in a genetic network motif
- (2010) M. Kittisopikul et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
- (2010) M. A. Curran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ZAP-70: An Essential Kinase in T-cell Signaling
- (2010) H. Wang et al. Cold Spring Harbor Perspectives in Biology
- Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells
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- The T-cell-receptor signaling network
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