High protein intake is associated with low plasma NAD+ levels in a healthy human cohort

Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach

(2017) Sonia Bustamante et al.   Metabolomics

Kynurenine pathway metabolism and neuroinflammatory disease

(2017) Nady Braidy et al.   Neural Regeneration Research

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

(2016) J.R. Speakman et al.   EXPERIMENTAL GERONTOLOGY

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

The sirtuins, oxidative stress and aging: an emerging link

(2016) Philip I. Merksamer et al.   Aging-US

Urea-induced ROS cause endothelial dysfunction in chronic renal failure

(2015) Maria D'Apolito et al.   ATHEROSCLEROSIS

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation

(2015) Ming-Hui Zou   Frontiers in Bioscience-Landmark

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

(2013) Edoardo Parrella et al.   AGING CELL

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease

(2012) Stephanie E. Chiuve et al.   JOURNAL OF NUTRITION

Niacin: chemical forms, bioavailability, and health effects

(2012) Douglas MacKay et al.   NUTRITION REVIEWS

Glutamine versus Ammonia Utilization in the NAD Synthetase Family

(2012) Jessica De Ingeniis et al.   PLoS One

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns

(2012) Hassina Massudi et al.   REDOX REPORT

Free [NADH]/[NAD+] regulates sirtuin expression

(2011) Juan Gambini et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

(2011) Thanh-Nhan Nguyen-Pham et al.   Cellular & Molecular Immunology

Calorie restriction and prevention of age-associated chronic disease

(2011) Daniela Omodei et al.   FEBS LETTERS

l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species

(2011) Hyunkeun Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Simultaneous determination of tryptophan, kynurenine and 5-hydroxytryptamine by HPLC: Application in uremic patients undergoing hemodialysis

(2010) Qianna Zhen et al.   CLINICAL BIOCHEMISTRY

Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)

(2009) Benjamin G. Fanson et al.   AGING CELL

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL