Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

(2017) Thi-Huong Nguyen et al.   Nature Communications

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

(2017) Stanley T. Crooke et al.   Nucleic Acid Therapeutics

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling

(2017) Annie Moisan et al.   Molecular Therapy-Nucleic Acids

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

(2016) Stanley T Crooke et al.   MOLECULAR THERAPY

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

(2016) Sabine Sewing et al.   PLoS One

Development of a Method for Profiling Protein Interactions with LNA-Modified Antisense Oligonucleotides Using Protein Microarrays

(2016) Satoko Kakiuchi-Kiyota et al.   Nucleic Acid Therapeutics

Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics

(2016) Scott P. Henry et al.   Nucleic Acid Therapeutics

A snapshot of biologic drug development

(2015) L Andrews et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

(2015) Ulrike Flierl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

(2015) Sebastien A. Burel et al.   NUCLEIC ACIDS RESEARCH

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

(2014) Andrew D. Burdick et al.   NUCLEIC ACIDS RESEARCH

Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in vitro prediction of antigenicity

(2014) Sven Brandt et al.   THROMBOSIS AND HAEMOSTASIS

Antisense Oligonucleotide Therapies

(2014) Kendall S. Frazier   TOXICOLOGIC PATHOLOGY

Mechanisms and etiologies of thrombocytopenia in the intensive care unit: impact of extensive investigations

(2014) Nadiejda Antier et al.   Annals of Intensive Care

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

(2013) M. E. Jaax et al.   BLOOD

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

(2013) Mark J. Graham et al.   CIRCULATION RESEARCH

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-leukocyte crosstalk: Linking proinflammatory responses to procoagulant state

(2012) Mehran Ghasemzadeh et al.   THROMBOSIS RESEARCH

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

(2012) Punit P Seth et al.   Molecular Therapy-Nucleic Acids

Heparin-Induced Thrombocytopenia

(2010) Gowthami M. Arepally et al.   Annual Review of Medicine

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

(2009) S. M. Mangsbo et al.   JOURNAL OF IMMUNOLOGY

In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates

(2009) Andrew J. Olaharski et al.   TOXICOLOGY LETTERS