TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons

Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity

(2016) Thomas Stueber et al.   ANESTHESIOLOGY

TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis

(2016) Éva Sághy et al.   GLIA

Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

(2016) Nicola B. Hamilton et al.   NATURE

The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain

(2015) S.E.I. van der Wal et al.   EUROPEAN JOURNAL OF PAIN

The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain

(2015) Robert Werdehausen et al.   PAIN

Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agents

(2014) Bernhard Stenger et al.   ARCHIVES OF TOXICOLOGY

Despite Differences in Cytosolic Calcium Regulation, Lidocaine Toxicity Is Similar in Adult and Neonatal Rat Dorsal Root Ganglia In Vitro

(2013) Lisa V. Doan et al.   ANESTHESIOLOGY

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6

(2013) Jeanne de la Roche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves

(2013) Daisuke Tomohiro et al.   LIFE SCIENCES

TRPA1 insensitivity of human sural nerve axons after exposure to lidocaine

(2013) Reginald J. Docherty et al.   PAIN

The Influence of Adjuvants Used in Regional Anesthesia on Lidocaine-Induced Neurotoxicity In Vitro

(2012) Robert Werdehausen et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

(2011) P. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

Differential effects on sensory functions and measures of epidermal nerve fiber density after application of a lidocaine patch (5%) on healthy human skin

(2011) Andreas Wehrfritzl et al.   EUROPEAN JOURNAL OF PAIN

Activation of TRPA1 by Membrane Permeable Local Anesthetics

(2011) Andreas Leffler et al.   Molecular Pain

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

(2011) David A Andersson et al.   Nature Communications

Models and Mechanisms of Local Anesthetic Cardiac Toxicity

(2010) John F. Butterworth   REGIONAL ANESTHESIA AND PAIN MEDICINE

TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase

(2009) Lian-Hua Piao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL