Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors

(2017) Weimei Xing et al.   PLoS One

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Antiviral therapy in seasonal influenza and 2009 H1N1 pandemic influenza: Korean experiences and perspectives

(2015) Joon Young Song et al.   Expert Review of Anti-Infective Therapy

Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

Antivirals for Treatment of Influenza

(2013) Jonathan Hsu et al.   ANNALS OF INTERNAL MEDICINE

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Chutes and ladders in hepatitis C nucleoside drug development

(2013) Steven J. Coats et al.   ANTIVIRAL RESEARCH

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

(2013) Zhinan Jin et al.   PLoS One

Functional Analysis of Conserved Motifs in Influenza Virus PB1 Protein

(2012) Caroline Chu et al.   PLoS One

Organization of the Influenza Virus Replication Machinery

(2012) A. Moeller et al.   SCIENCE

A 40-Year Journey in Search of Selective Antiviral Chemotherapy*

(2011) Erik De Clercq   Annual Review of Pharmacology and Toxicology

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

(2011) Yohichi Kumaki et al.   ANTIVIRAL RESEARCH

Regulation of Influenza RNA Polymerase Activity and the Switch between Replication and Transcription by the Concentrations of the vRNA 5′ End, the Cap Source, and the Polymerase

(2010) Andrew C. Olson et al.   BIOCHEMISTRY

Towards an atomic resolution understanding of the influenza virus replication machinery

(2010) Rob WH Ruigrok et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms

(2010) Stéphane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biochemical Characterization of Enzyme Fidelity of Influenza A Virus RNA Polymerase Complex

(2010) Shilpa Aggarwal et al.   PLoS One

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells

(2009) Shijian Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

(2009) Kanako Sugiyama et al.   EMBO JOURNAL

Genome packaging in influenza A virus

(2009) E. C. Hutchinson et al.   JOURNAL OF GENERAL VIROLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY