Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria

Lipopolysaccharide Neutralization by Cationic-Amphiphilic Polymers through Pseudoaggregate Formation

(2016) Divakara S. S. M. Uppu et al.   BIOMACROMOLECULES

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

(2016) Divakara S S M Uppu et al.   BIOMATERIALS

Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers

(2016) D. S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

NH125 kills methicillin-resistantStaphylococcus aureuspersisters by lipid bilayer disruption

(2016) Wooseong Kim et al.   Future Medicinal Chemistry

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Antibiofilm Peptides Increase the Susceptibility of Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates to β-Lactam Antibiotics

(2015) Suzana Meira Ribeiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–Activity Relationship of Amino Acid Tunable Lipidated Norspermidine Conjugates: Disrupting Biofilms with Potent Activity against Bacterial Persisters

(2015) Mohini M. Konai et al.   BIOCONJUGATE CHEMISTRY

Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

(2015) Jiaul Hoque et al.   CHEMICAL COMMUNICATIONS

D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

(2015) César de la Fuente-Núñez et al.   CHEMISTRY & BIOLOGY

Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing ofMycobacteriumby Targeting Its DNA

(2015) Aashish Sharma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synergistic killing of NDM-producing MDRKlebsiella pneumoniaeby two ‘old’ antibiotics—polymyxin B and chloramphenicol

(2015) Nusaibah Abdul Rahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms

(2015) Runhui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus

(2015) Isabel C.M. Fensterseifer et al.   PEPTIDES

Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

(2015) Divakara S. S. M. Uppu et al.   PLoS One

Controlling macromolecular structures towards effective antimicrobial polymers

(2015) Mitra S. Ganewatta et al.   POLYMER

Helical antimicrobial polypeptides with radial amphiphilicity

(2015) Menghua Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Persister-Specific Antibiotics with Synergistic Antimicrobial Functions

(2014) Nathan W. Schmidt et al.   ACS Nano

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Biofilm-Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides

(2014) Megan C. Jennings et al.   CHEMBIOCHEM

Antibiotic Adjuvants: Diverse Strategies for Controlling Drug-Resistant Pathogens

(2014) Erin E. Gill et al.   Chemical Biology & Drug Design

Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci

(2014) Haroon Mohammad et al.   JOURNAL OF ANTIBIOTICS

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria

(2014) G. Cox et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New Ianthelliformisamine Derivatives as Antibiotic Enhancers against Resistant Gram-Negative Bacteria

(2014) Cyril Pieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Injectable bioadhesive hydrogels with innate antibacterial properties

(2014) Michael C. Giano et al.   Nature Communications

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

Designing Mimics of Membrane Active Proteins

(2013) Federica Sgolastra et al.   ACCOUNTS OF CHEMICAL RESEARCH

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

(2013) Tyler L. Harris et al.   ACS Chemical Biology

Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections

(2013) Mehdi Kazemzadeh-Narbat et al.   BIOMATERIALS

Controlling persister cells of Pseudomonas aeruginosa PDO300 by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one

(2013) Jiachuan Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antimicrobial peptides againstPseudomonas syringaepv.actinidiaeandErwinia amylovora: Chemical synthesis, secondary structure, efficacy, and mechanistic investigations

(2013) Alan Cameron et al.   BIOPOLYMERS

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

(2013) Divakara S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

Sensitization of gram-negative bacteria by targeting the membrane potential

(2013) Keren Goldberg et al.   FASEB JOURNAL

Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers

(2013) Haruko Takahashi et al.   MACROMOLECULAR BIOSCIENCE

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

A problem of persistence: still more questions than answers?

(2013) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic

(2013) Danielle M. McGrath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

(2013) J. R. Morones-Ramirez et al.   Science Translational Medicine

Cephalosporin-3′-diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms

(2012) Nicolas Barraud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies

(2012) Yan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acinetobacter in modern warfare

(2012) M.K. O'Shea   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lipo-γ-AApeptides as a New Class of Potent and Broad-Spectrum Antimicrobial Agents

(2012) Youhong Niu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells

(2011) Jun-Seob Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

(2010) R. L. Soon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Functional polymers as therapeutic agents: Concept to market place

(2009) Pradeep K. Dhal et al.   ADVANCED DRUG DELIVERY REVIEWS

XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms

(2009) N. Ooi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms

(2008) K. Flemming et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

(2008) Sünje Johanna Pamp et al.   MOLECULAR MICROBIOLOGY