Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation

Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes

(2016) Shruti Chowdhari et al.   CELLULAR SIGNALLING

Lysosomal signaling in control of degradation pathways

(2016) Lukas A Huber et al.   CURRENT OPINION IN CELL BIOLOGY

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

(2016) Olufolake Akinduro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

(2016) Xiaolei Ding et al.   Nature Communications

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation

(2015) A S Naeem et al.   CELL DEATH AND DIFFERENTIATION

8-methoxypsoralen plus UVA (PUVA) therapy normalizes signalling of phosphorylated component of mTOR pathway in psoriatic skin of K5.hTGFβ1 transgenic mice

(2015) Nitesh Shirsath et al.   EXPERIMENTAL DERMATOLOGY

Dissecting the formation, structure and barrier function of the stratum corneum

(2015) Takeshi Matsui et al.   INTERNATIONAL IMMUNOLOGY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?

(2014) T Huang et al.   ACTA DERMATO-VENEREOLOGICA

Combination of everolimus and tacrolimus: a potentially effective regimen for recalcitrant psoriasis

(2014) Kai-Che Wei et al.   Dermatologic Therapy

Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints

(2014) Valeria Orecchia et al.   EXPERIMENTAL DERMATOLOGY

Cell death by cornification

(2013) Leopold Eckhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin

(2013) C. Buerger et al.   BRITISH JOURNAL OF DERMATOLOGY

Regulation of Involucrin in Psoriatic Epidermal Keratinocytes: The Roles of ERK1/2 and GSK-3β

(2013) Jia-Qi Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

1α,25-Dihydroxyvitamin-D3-3-Bromoacetate Regulates AKT/mTOR Signaling Cascades: A Therapeutic Agent for Psoriasis

(2013) Ananya Datta Mitra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

(2013) Michelle A. Lowes et al.   TRENDS IN IMMUNOLOGY

mTOR signaling cascade in psoriatic disease: Double kinase mtor inhibitor a novel therapeutic target

(2013) SibaR Raychaudhuri et al.   INDIAN JOURNAL OF DERMATOLOGY

STAT1 expression and activation is increased in lesional psoriatic skin

(2012) A. Hald et al.   BRITISH JOURNAL OF DERMATOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Interleukin-1β Interferes with Epidermal Homeostasis through Induction of Insulin Resistance: Implications for Psoriasis Pathogenesis

(2012) Claudia Buerger et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling

(2012) K Sully et al.   ONCOGENE

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion

(2012) Yeon Ja Choi et al.   PLoS One

Autophagy in human keratinocytes: an early step of the differentiation?

(2010) Elodie Aymard et al.   EXPERIMENTAL DERMATOLOGY

The expression and phosphorylation of eukaryotic initiation factor 4E are increased in lesional psoriatic skin

(2009) R.B. Kjellerup et al.   BRITISH JOURNAL OF DERMATOLOGY

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2

(2009) S-J. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients

(2009) Robyn P. Hickerson et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of Keratinocyte Protein Kinase Cζ in Psoriasis Plaques

(2008) Yuming Zhao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY