The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling

Loss of Endogenous Interleukin-12 Activates Survival Signals in Ultraviolet-Exposed Mouse Skin and Skin Tumors

(2015) Syed M. Meeran et al.   NEOPLASIA

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer

(2011) Gerd P. Pfeifer et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial

(2011) Josefina Alberú et al.   TRANSPLANTATION

The Importance of Skin Cancer Prevention in Organ Transplant Patients
An Editorial to Paper by Salgo: ‘Switch to Sirolimus in Long-Term Renal Transplant Recipients: Reduced Premalignancies and Nonmelanoma Skin Cancer in a Controlled, Prospective, Randomiz

(2010) C. Mitchell   AMERICAN JOURNAL OF TRANSPLANTATION

Switch to a Sirolimus-Based Immunosuppression in Long-Term Renal Transplant Recipients: Reduced Rate of (Pre-)Malignancies and Nonmelanoma Skin Cancer in a Prospective, Randomized, Assessor-Blinded, Controlled Clinical Trial

(2010) R. Salgo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mammalian Target of Rapamycin Activator RHEB Is Frequently Overexpressed in Human Carcinomas and Is Critical and Sufficient for Skin Epithelial Carcinogenesis

(2010) Z. H. Lu et al.   CANCER RESEARCH

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

(2010) Irantzu Tato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Can sirolimus prevent skin cancer in transplant recipients?

(2010) Edward K. Geissler et al.   Nature Reviews Nephrology

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development

(2009) R. F. L. O'Shaughnessy et al.   DEVELOPMENT

Parameters of protection against ultraviolet radiation-induced skin cell damage

(2009) Cong Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice

(2009) G E Koehl et al.   ONCOGENE

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors

(2008) Josep Tabernero et al.   JOURNAL OF CLINICAL ONCOLOGY

Sirolimus Reduces the Incidence and Progression of UVB-Induced Skin Cancer in SKH Mice even with Co-administration of Cyclosporine A

(2008) Brian C. Wulff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Class I PI3K in oncogenic cellular transformation

(2008) L Zhao et al.   ONCOGENE