Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis

The microglial ATP-gated ion channel P2X7 as a CNS drug target

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Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study

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Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity

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Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients

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Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

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Association of TLR4 Gene rs2149356 Polymorphism with Primary Gouty Arthritis in a Case-Control Study

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P2X7R: A potential key regulator of acute gouty arthritis

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Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms

(2013) Lin-Hua Jiang et al.   Frontiers in Pharmacology

The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

(2012) Anke Wesselius et al.   BMC IMMUNOLOGY

Allopurinol Acutely Increases Adenosine Triphospate Energy Delivery in Failing Human Hearts

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Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

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Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action

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Gain-of-function of P2X7 receptor gene variants in multiple sclerosis

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Reproducibility of musculoskeletal ultrasound for determining monosodium urate deposition: Concordance between readers

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Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study

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Cellular characterization of the gouty tophus: A quantitative analysis

(2010) Nicola Dalbeth et al.   ARTHRITIS AND RHEUMATISM

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Mechanisms of uric acid crystal-mediated autoinflammation

(2009) Fabio Martinon   IMMUNOLOGICAL REVIEWS

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

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Asymptomatic Hyperuricemia: Impact of Ultrasonography

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Primer: inflammasomes and interleukin 1β in inflammatory disorders

(2008) Leigh D Church et al.   Nature clinical practice. Rheumatology