Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

(2014) M. Cane et al.   JOURNAL OF NEUROSCIENCE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Balance and Stability of Synaptic Structures during Synaptic Plasticity

(2014) Daniel Meyer et al.   NEURON

Dendritic Spines: The Locus of Structural and Functional Plasticity

(2014) Carlo Sala et al.   PHYSIOLOGICAL REVIEWS

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

(2014) E. Santini et al.   Science Signaling

Enhanced synapse remodelling as a common phenotype in mouse models of autism

(2014) Masaaki Isshiki et al.   Nature Communications

Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

(2014) S J James et al.   Translational Psychiatry

Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: Implications for autism spectrum disorders

(2013) Paola Sgadò et al.   EXPERIMENTAL NEUROLOGY

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors

(2013) Harold D. MacGillavry et al.   NEURON

Acute Physiological Stress Promotes Clustering of Synaptic Markers and Alters Spine Morphology in the Hippocampus

(2013) Veronica Sebastian et al.   PLoS One

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

(2013) S J James et al.   Translational Psychiatry

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum

(2012) Grant D. Orvis et al.   DEVELOPMENTAL BIOLOGY

Engrailed Is Required in Maturing Serotonin Neurons to Regulate the Cytoarchitecture and Survival of the Dorsal Raphe Nucleus

(2012) S. R. Fox et al.   JOURNAL OF NEUROSCIENCE

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Autism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice

(2012) Jennifer Brielmaier et al.   PLoS One

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones

(2011) O. Stettler et al.   DEVELOPMENT

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults

(2011) Daniel Alvarez-Fischer et al.   NATURE NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Alterations of GABAergic Signaling in Autism Spectrum Disorders

(2011) Rocco Pizzarelli et al.   NEURAL PLASTICITY

Autism: A “Critical Period” Disorder?

(2011) Jocelyn J. LeBlanc et al.   NEURAL PLASTICITY

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Engrailed Homeobox Genes Regulate Establishment of the Cerebellar Afferent Circuit Map

(2010) R. V. Sillitoe et al.   JOURNAL OF NEUROSCIENCE

How It's Made: The Synapse

(2010) L. A. D. Bury et al.   MOLECULAR INTERVENTIONS

Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex

(2010) Beatriz Cubelos et al.   NEURON

Autism-Associated Haplotype Affects the Regulation of the Homeobox Gene, ENGRAILED 2

(2009) Rym Benayed et al.   BIOLOGICAL PSYCHIATRY

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

A synaptic trek to autism

(2009) Thomas Bourgeron   CURRENT OPINION IN NEUROBIOLOGY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo

(2009) Andrea Wizenmann et al.   NEURON

Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice

(2009) P.P. Tripathi et al.   NEUROSCIENCE

A Fast Thresholded Landweber Algorithm for Wavelet-Regularized Multidimensional Deconvolution

(2008) C. Vonesch et al.   IEEE TRANSACTIONS ON IMAGE PROCESSING

Engrailed-2 regulates genes related to vesicle formation and transport in cerebellar Purkinje cells

(2008) Martin I. Holst et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

Excitation control: balancing PSD-95 function at the synapse

(2008) Dove Keith   Frontiers in Molecular Neuroscience