Article
Endocrinology & Metabolism
Jiyoung Oh, Chu-Sook Kim, Min Kim, Woobeen Jo, Young Hoon Sung, Jiyoung Park
Summary: The study reveals the crucial role of Col6a3 in mature adipocyte differentiation, inflammation, lipolysis, and insulin sensitivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Louise Moller, Stefanie Thoeni, Felix Keller, Samir Sharifli, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Gert Mayer
Summary: This study investigated the effect of combination therapy of renin-angiotensin system inhibition and sodium-glucose co-transporter-2 inhibitors on endotrophin levels in individuals with type 2 diabetes. The results showed that combination therapy led to a significant reduction in endotrophin levels and a lower risk of kidney disease progression.
Article
Biochemistry & Molecular Biology
Alexandra Louise Moller, Ninna Hahn Tougaard, Daniel Guldager Kring Rasmussen, Federica Genovese, Pernille Falberg Ronn, Tine Willum Hansen, Morten Asser Karsdal, Peter Rossing
Summary: The pro-fibrotic molecule endotrophin, generated during collagen type VI formation, has been identified as a potential risk marker for complications in type 1 diabetes. Higher levels of serum endotrophin were associated with kidney complications and increased mortality in type 1 diabetes patients. However, there was no significant association between serum endotrophin and cardiovascular events or diabetic eye disease. Urinary endotrophin was not found to be associated with any outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Guldager Kring Rasmussen, Michael K. Hansen, Joseph Blair, Timothy A. Jatkoe, Bruce Neal, Morten A. Karsdal, Federica Genovese
Summary: It was found in this study that endotrophin (ETP) generated during the formation of collagen type VI predicts cardiovascular, kidney, and mortality outcomes in patients with type 2 diabetes. Therefore, ETP may be used for patient enrichment in future clinical trials.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Murilo Guedes, Daniel G. Muenz, Jarcy Zee, Brian Bieber, Benedicte Stengel, Ziad A. Massy, Nicolas Mansencal, Michelle M. Y. Wong, David M. Charytan, Helmut Reichel, Sandra Waechter, Ronald L. Pisoni, Bruce M. Robinson, Roberto Pecoits-Filho
Summary: The study found that iron deficiency in patients with nondialysis CKD is associated with higher risks of all-cause mortality and major adverse cardiovascular events. Interventional studies are needed to evaluate the impact of iron supplementation on clinical outcomes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Article
Transplantation
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten Asser Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Mads Hornum, Lenka Bartonova, Eva Honsova, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: This study found that levels of circulating and excreted ETP are associated with kidney function, CKD severity, and the extent of interstitial fibrosis, gradually increasing with higher fibrotic burden. ETP outperformed the known fibrosis biomarker Dickkopf-3 in discriminating patients with high fibrotic burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Nutrition & Dietetics
Qiang Zhong, YongYi Piao, Shan Yin, KangYi Zhang
Summary: This study found that higher serum lycopene concentrations were significantly associated with a decreased risk of all-cause and cardiovascular disease mortality in patients with chronic kidney disease (CKD).
FRONTIERS IN NUTRITION
(2022)
Review
Medicine, General & Internal
Kamyar Kalantar-Zadeh, Tazeen H. Jafar, Dorothea Nitsch, Brendon L. Neuen, Vlado Perkovic
Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.
Article
Health Care Sciences & Services
Rumen Filev, Mila Lyubomirova, Julieta Hristova, Boris Bogov, Krassimir Kalinov, Dobrin Svinarov, Lionel Rostaing
Summary: In this study, various plasma and urinary biomarkers were assessed in COVID-19 patients, and their correlation with outcomes (death, AKI) was investigated. The findings showed that certain biomarkers, particularly IL-6, were significantly associated with mortality and AKI. However, the prediction of AKI was not possible. Additionally, the severity score from chest CT-scan was strongly linked to mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Jia Li, Dongwei Liu, Zhangsuo Liu
Summary: The study found that elevated serum total bilirubin levels within the physiological range are associated with a lower risk of chronic kidney disease and show a linear dose-response relationship, but whether high STB levels are a protective factor against mortality remains inconclusive.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Carolla El Chamieh, Islam Amine Larabi, Natalia Alencar De Pinho, Oriane Lambert, Christian Combe, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Solene Laville, Celine Lange, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: In this study, the association between serum-free kynurenine levels and cardiovascular events and mortality in patients with chronic kidney disease (CKD) was evaluated. The results showed that serum-free kynurenine levels were independently associated with fatal or nonfatal cardiovascular events, particularly non-atheromatous cardiovascular events in CKD patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Immunology
Kit P. Lund, Frank Eriksson, Anne W. Hauge, Helena Mora-Jensen, Soren S. Sorensen, Helle Bruunsgaard
Summary: The study suggests that specific HLA class II phenotypes may impact immunological activity and complications after kidney transplantation. HLA-IMD phenotypes were associated with elevated levels of systemic inflammation biomarkers, and HLA-DR4-DQ8 phenotype was linked to mortality after transplantation.
CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Elizabeth M. Brookes, Jonathan Snider, Graeme K. Hart, Raymond Robbins, David A. Power
Summary: It was found that both hyperkalaemia and hypokalaemia occurred in 6.86% and 2.94% of CKD inpatients respectively. Factors such as male sex, lower eGFR, diabetes, and cardiac failure were associated with higher odds of hyperkalaemia, while thiazide diuretics, loop diuretics, infectious disease, and endocrine pathology were associated with higher odds of hypokalaemia. A U-shaped association was noted between potassium and inpatient mortality.
INTERNAL MEDICINE JOURNAL
(2021)
Review
Peripheral Vascular Disease
Jonathan P. Law, Luke Pickup, Davor Pavlovic, Jonathan N. Townend, Charles J. Ferro
Summary: Chronic kidney disease (CKD) is a complex condition that affects 10-15% of the global population. There is an inverse relationship between kidney function and cardiovascular events and mortality, independent of age, sex, and other risk factors. The development of CKD-associated cardiomyopathy, characterized by left ventricular changes and fibrosis, is significantly influenced by hypertension. Even in mild to moderate renal impairment, structural and functional changes consistent with CKD-associated cardiomyopathy can be observed.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Letter
Dermatology
Signe Holm Nielsen, Solveig Skovlund Groen, Yiqiu Yao, Astrid-Helene Ravn Jorgensen, Valdemar Wendelboe Nielsen, Morten Karsdal, Kristoffer Gehring, Anne-Christine Bay-Jensen, Simon Francis Thomsen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Transplantation
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty among haemodialysis patients is associated with hospitalization and mortality, but further discrimination of risk is needed due to the high prevalence of frailty. This study found that incorporating self-reported health with frailty measurement can help identify the most at-risk frail individuals.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Depression and frailty are common in haemodialysis recipients and are associated with negative outcomes. When taking frailty into account, depression is associated with lower hospitalization rates but poorer quality of life. Frailty is associated with higher admission rates, mortality, and poorer quality of life. The relationship between frailty and depression and their influence on outcomes is complex and requires further study.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Charles J. Ferro, Alberto Ortiz, Maria Jose Soler, Jean-Michel Halimi, Andrzej Januszewicz, Alexandre Persu, Reinhold Kreutz, Pantelis Sarafidis
Summary: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has become a global pandemic since December 2019. The public restrictive measures implemented in different countries have greatly affected people's daily activities. It is important to understand the impact of these measures on hypertension incidence and blood pressure control.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Alexander D. Lalayiannis, Nicola J. Crabtree, Charles J. Ferro, David C. Wheeler, Neill D. Duncan, Colette Smith, Joyce Popoola, Askiti Varvara, Andromachi Mitsioni, Amrit Kaur, Manish D. Sinha, Lorenzo Biassoni, Simon P. McGuirk, Kristian H. Mortensen, David V. Milford, Jin Long, Mary D. Leonard, Mary Fewtrell, Rukshana Shroff
Summary: This multicenter longitudinal study found that while older adults with chronic kidney disease (CKD) may experience increases in bone mineral density (BMD), they can still develop vascular calcification. In contrast, the growing skeleton of children and young adults with CKD may offer protection against extraosseous calcification. These findings suggest that the growing skeleton may have a buffering capacity against non-skeletal calcification.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Michaela Neprasova, Dita Maixnerova, Nadja Sparding, Federica Genovese, Morten Asser Karsdal, Helena Koprivova, Marek Kollar, Miloslav Suchanek, Zdenka Hruskova, Vladimir Tesar
Summary: By evaluating biomarkers related to kidney fibrosis, we can predict the outcome of patients with IgA nephropathy (IgAN). Clinical parameters and histological findings can be used to predict the kidney outcome. Biomarkers of collagen and laminin turnover in serum and urine can significantly differentiate IgAN patients with a worse prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Nicola C. Edwards, Anna M. Price, Richard P. Steeds, Charles J. Ferro, Jonathan N. Townend
Summary: There is a significant overlap between chronic kidney disease (CKD) and chronic heart failure (HF), making it important for nephrologists to be familiar with the 2021 European Society of Cardiology guidelines. The guidelines have evolved to focus on identifying phenotypes of HF for evidence-based management and provide a simplified treatment algorithm for HF with reduced ejection fraction. Additionally, there are changes in device therapy recommendations and updated treatment plans for HF with non-cardiovascular comorbidities including CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Daisy V. Wilson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study investigates the relationship between ultrasound-derived anterior thigh thickness and frailty in haemodialysis recipients. The results show that anterior thigh thickness is associated with frailty by different frailty tools, but its association is not independent of other variables. Further research is needed to establish the added value of muscle mass measurement in frail haemodialysis patients.
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study examined the accuracy of subjective and multidisciplinary assessment of the Clinical Frailty Scale (CFS-MDT) compared to the standard CFS score. The study found that there was weak correlation and minimal agreement between these two assessment methods. Both scores were associated with hospitalization and mortality, but only the CFS-MDT was associated with the length of hospital stay.
Article
Biochemistry & Molecular Biology
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten A. Karsdal, Nicoline V. Krogstrup, Marie Bodilsen Nielsen, Mads Hornum, Subagini Nagarajah, Henrik Birn, Bente Jespersen, Martin Tepel, Rikke Norregaard
Summary: This study evaluated endotrophin (ETP) as a prognostic marker in kidney transplant recipients. It found that ETP levels in the blood on the first day after transplantation were strongly associated with delayed graft function, while ETP levels in the urine at the third month after transplantation were significantly correlated with kidney graft function at twelve months. The measurement of collagen type VI formation could aid in predicting graft function in kidney transplant recipients.
Article
Biochemistry & Molecular Biology
Nadja Sparding, Michaela Neprasova, Dita Maixnerova, Federica Genovese, Morten Asser Karsdal, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: Kidney fibrosis, a characteristic of chronic kidney disease, can be assessed by measuring different biomarkers of collagen type III. In this study, three collagen type III biomarkers were measured in serum and urine samples of IgA nephropathy patients. The results showed that these biomarkers provided different information about fibrotic burden and had different correlations with the degree of fibrosis in kidney biopsies. Measuring different fragments of the same ECM protein in different matrices can provide valuable insights into pathological kidney tissue alterations in patients with IgA nephropathy.
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Katherine R. R. Tuttle, Jonathan M. Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten A. Karsdal, Kevin L. L. Duffin, Fady T. Botros
Summary: In the AWARD-7 study, once-weekly dulaglutide treatment in patients with type 2 diabetes and chronic kidney disease demonstrated a slower decline in eGFR and a reduction in urine albumin/creatinine ratio compared to insulin glargine. This exploratory analysis found that dulaglutide treatment was associated with lower levels of PRO-C6 and higher levels of C3M, indicating reduced type VI collagen formation and increased type III collagen degradation, suggesting a potential mechanism for reducing kidney fibrosis.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)