The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure

(2016) Aditya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

(2016) Marija Iljina et al.   Scientific Reports

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

Diffusion NMR study of complex formation in membrane-associated peptides

(2013) Suliman Barhoum et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

(2013) Nikolai Lorenzen et al.   FEBS LETTERS

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles

(2013) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes

(2013) Igor Dikiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates

(2013) Alexander S. Maltsev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

(2013) Lijuan Kang et al.   PLoS One

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation

(2012) Naoko Mizuno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Oligomers of Heterogeneous Size as Precursors of Amyloid Fibril Nucleation of an SH3 Domain: An Experimental Kinetics Study

(2012) David Ruzafa et al.   PLoS One

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease

(2010) Allan Chris M. Ferreon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid Formation in Surfactants and Alcohols: Membrane Mimetics or Structural Switchers?

(2010) Daniel E. Otzen   CURRENT PROTEIN & PEPTIDE SCIENCE

α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

(2010) Frédéric Darios et al.   EMBO REPORTS

The Lipid-binding Domain of Wild Type and Mutant α-Synuclein

(2010) Elka R. Georgieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

(2010) Lise Giehm et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli

(2010) Matthew Johnson et al.   PLoS One

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

(2009) Christofer Lendel et al.   BIOCHEMISTRY

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants

(2009) Jason D. Perlmutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Insights into the Interaction between α-Synuclein and Docosahexaenoic Acid

(2009) Giorgia De Franceschi et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of Pseudorepeat Rearrangement on α-Synuclein Misfolding, Vesicle Binding, and Micelle Binding

(2009) Jampani Nageswara Rao et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interplay of  -synuclein binding and conformational switching probed by single-molecule fluorescence

(2009) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Molecule FRET Reveals Structural Heterogeneity of SDS-Bound α-Synuclein

(2008) Gertjan Veldhuis et al.   CHEMBIOCHEM

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

(2008) Elka R. Georgieva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of the aggregation behavior of α- and β-synuclein

(2008) Robert C. Rivers et al.   PROTEIN SCIENCE

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY