Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β

Free fatty acids sensitize dendritic cells to amplify TH1/TH17-immune responses

(2016) Kristin Stelzner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Even free radicals should follow some rules: A Guide to free radical research terminology and methodology

(2015) Henry Jay Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of Anti-Long Chain Saturated Fatty Acid IgG Antibodies in Serum of Patients with Type 2 Diabetes

(2015) Dequina A. Nicholas et al.   MEDIATORS OF INFLAMMATION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production

(2015) Blanche Ip et al.   Obesity

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine

(2015) Jacques C. Mbongue et al.   PLoS One

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers

(2014) B. G. Pierce et al.   BIOINFORMATICS

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF- -Induced Foxp3 Expression

(2014) S. Ikeda et al.   JOURNAL OF IMMUNOLOGY

Quantitative Proteomics Reveals a Role for Epigenetic Reprogramming During Human Monocyte Differentiation

(2014) Dequina Nicholas et al.   MOLECULAR & CELLULAR PROTEOMICS

Effects of LPS and dietary free fatty acids on MCP-1 in 3T3-L1 adipocytes and macrophages in vitro

(2014) K B Cullberg et al.   Nutrition & Diabetes

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability

(2013) Ori Nov et al.   PLoS One

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

(2012) Clare M. Reynolds et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells

(2012) Xiaoqin Luo et al.   Nutrition & Metabolism

Toll-like receptors, the NLRP3 inflammasome and interleukin-1β in the development and progression of type 1 diabetes

(2012) Ellen K. Grishman et al.   PEDIATRIC RESEARCH

Calibration of nanowatt isothermal titration calorimeters with overflow reaction vessels

(2011) Neil A. Demarse et al.   ANALYTICAL BIOCHEMISTRY

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals

(2011) Rosa Barreira da Silva et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis

(2011) Gabriella Leonarduzzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

n−3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

(2011) Saame Raza Shaikh et al.   MOLECULAR ASPECTS OF MEDICINE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus

(2011) Dwi Setyowati Karolina et al.   PLoS One

Development of Mass Spectrometry-Based Shotgun Method for Proteome Analysis of 500 to 5000 Cancer Cells

(2010) Nan Wang et al.   ANALYTICAL CHEMISTRY

Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity

(2010) Amelia Padilla et al.   BRAIN RESEARCH

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty acids as metabolic mediators in innate immunity

(2009) A. Kopp et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mycobacteria Exploit p38 Signaling To Affect CD1 Expression and Lipid Antigen Presentation by Human Dendritic Cells

(2009) M. C. Gagliardi et al.   INFECTION AND IMMUNITY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

(2009) Hideki Nakano et al.   NATURE IMMUNOLOGY

Different cross-presentation pathways in steady-state and inflammatory dendritic cells

(2009) E. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free Fatty Acid Receptors and Drug Discovery

(2008) Akira Hirasawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Serum lipids regulate dendritic cell CD1 expression and function

(2008) David S. Leslie et al.   IMMUNOLOGY

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation and reversal of lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid

(2008) Frankis G. Almaguel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

(2008) Arion Kennedy et al.   JOURNAL OF NUTRITION

Identification of High Affinity Fatty Acid Binding Sites on Human Serum Albumin by MM-PBSA Method

(2007) Shin-ichi Fujiwara et al.   BIOPHYSICAL JOURNAL