Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer

Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling

(2015) AKM Azad et al.   BMC Systems Biology

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma

(2015) Francisco Azuaje et al.   Cell Communication and Signaling

Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells

(2015) Kaleigh Canfield et al.   CELL CYCLE

Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2

(2015) Sergey V. Karakashev et al.   Oncotarget

ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

(2015) Junwei Han et al.   Scientific Reports

Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

(2015) Timothy J. Stuhlmiller et al.   Cell Reports

Mechanisms of resistance to EGFR tyrosine kinase inhibitors

(2015) Lihua Huang et al.   Acta Pharmaceutica Sinica B

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor

(2015) Koichi Azuma et al.   Oncotarget

Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks

(2014) Ye Tian et al.   BMC Systems Biology

The Hippo pathway in chemotherapeutic drug resistance

(2014) Yulei Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

A novel dysregulated pathway-identification analysis based on global influence of within-pathway effects and crosstalk between pathways

(2014) J. Han et al.   Journal of the Royal Society Interface

DDB2 Suppresses Tumorigenicity by Limiting the Cancer Stem Cell Population in Ovarian Cancer

(2014) Chunhua Han et al.   MOLECULAR CANCER RESEARCH

EDDY: a novel statistical gene set test method to detect differential genetic dependencies

(2014) Sungwon Jung et al.   NUCLEIC ACIDS RESEARCH

Genetic modifiers of EGFR dependence in non-small cell lung cancer

(2014) Tanaz Sharifnia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer

(2014) Andrew T. Baker et al.   Frontiers in Oncology

PhosphoNetworks: a database for human phosphorylation networks

(2013) J. Hu et al.   BIOINFORMATICS

The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer

(2013) Yan Ni Loh et al.   BMC CANCER

DDB2: A Novel Regulator of NF- B and Breast Tumor Invasion

(2013) M. Ennen et al.   CANCER RESEARCH

HER2 and lung cancer

(2013) Lorenza Landi et al.   Expert Review of Anticancer Therapy

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

(2013) Violeta Serra et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

(2013) Sampurna Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined Treatment with Erlotinib and a Transforming Growth Factor-β Type I Receptor Inhibitor Effectively Suppresses the Enhanced Motility of Erlotinib-Resistant Non–Small-Cell Lung Cancer Cells

(2013) Masakuni Serizawa et al.   Journal of Thoracic Oncology

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Signaling cross-talk in the resistance to HER family receptor targeted therapy

(2013) H Yamaguchi et al.   ONCOGENE

Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance

(2013) C. Boeckx et al.   ONCOLOGIST

Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells

(2013) Rebecca Lamb et al.   PLoS One

SMAD4 is a potential prognostic marker in human breast carcinomas

(2013) Nan-nan Liu et al.   TUMOR BIOLOGY

De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

(2013) David Akhavan et al.   Cancer Discovery

Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer

(2013) Nir Peled et al.   CELLULAR ONCOLOGY

LAPATINIB IN BREAST CANCER - THE PREDICTIVE SIGNIFICANCE OF HER1 (EGFR), HER2, PTEN AND PIK3CA GENES AND LAPATINIB PLASMA LEVEL ASSESSMENT

(2012) Katerina Bouchalova et al.   BIOMEDICAL PAPERS-OLOMOUC

Deregulated Signaling Pathways in Glioblastoma Multiforme: Molecular Mechanisms and Therapeutic Targets

(2012) Hua Mao et al.   CANCER INVESTIGATION

Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

(2012) J. S. Logue et al.   GENES & DEVELOPMENT

Metabolic rewiring drives resistance to targeted cancer therapy

(2012) Jason W Locasale   Molecular Systems Biology

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines

(2012) Craig Carson et al.   Pigment Cell & Melanoma Research

Activation Status of Wnt/ß-Catenin Signaling in Normal and Neoplastic Breast Tissues: Relationship to HER2/neu Expression in Human and Mouse

(2012) Sara Khalil et al.   PLoS One

Switching addictions between HER2 and FGFR2 in HER2-positive breast tumor cells: FGFR2 as a potential target for salvage after lapatinib failure

(2011) Koichi Azuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 Modulates Acquired Resistance to EGFR Inhibitors and Radiation

(2011) S. Huang et al.   CANCER RESEARCH

Aberrant signaling pathways in pancreatic cancer: A two compartment view

(2011) Angela L. McCleary-Wheeler et al.   MOLECULAR CARCINOGENESIS

WikiPathways: building research communities on biological pathways

(2011) T. Kelder et al.   NUCLEIC ACIDS RESEARCH

Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer

(2011) C G Roberts et al.   ONCOGENE

A Gene Expression Signature of Acquired Chemoresistance to Cisplatin and Fluorouracil Combination Chemotherapy in Gastric Cancer Patients

(2011) Hark Kyun Kim et al.   PLoS One

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

(2011) J. T. Garrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC

(2011) Ballas et al.   OncoTargets and Therapy

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers

(2011) H. W. Cheung et al.   Cancer Discovery

Bayesian statistical modelling of human protein interaction network incorporating protein disorder information

(2010) Svetlana Bulashevska et al.   BMC BIOINFORMATICS

Resistance to ErbB2 Tyrosine Kinase Inhibitors in Breast Cancer Is Mediated by Calcium-Dependent Activation of RelA

(2010) W. Xia et al.   MOLECULAR CANCER THERAPEUTICS

Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

(2010) H. Al-Hussaini et al.   MOLECULAR CANCER THERAPEUTICS

Automated Network Analysis Identifies Core Pathways in Glioblastoma

(2010) Ethan Cerami et al.   PLoS One

An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules

(2009) Huaxia Qin et al.   BMC Systems Biology

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

(2009) Keng Boon Wee et al.   PLoS One

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

A novel signaling pathway impact analysis

(2008) Adi Laurentiu Tarca et al.   BIOINFORMATICS

Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235

(2008) P. J.A. Eichhorn et al.   CANCER RESEARCH

Acquired Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors Associated with a Novel T854A Mutation in a Patient with EGFR-Mutant Lung Adenocarcinoma

(2008) J. Bean et al.   CLINICAL CANCER RESEARCH

Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Cancer Cells

(2008) R. Bianco et al.   CLINICAL CANCER RESEARCH

Damaged DNA Binding Protein 2 Plays a Role in Breast Cancer Cell Growth

(2008) Zilal Kattan et al.   PLoS One