Article
Nutrition & Dietetics
Masaki Takahashi, Yui Mineshita, Jumpei Yamagami, Chunyi Wang, Kyoko Fujihira, Yu Tahara, Hyeon-Ki Kim, Takashi Nakaoka, Shigenobu Shibata
Summary: This study found that taking mulberry leaf extract in the evening can improve glucose tolerance. Additionally, taking mulberry leaf extract in the morning can reduce insulin concentrations. Therefore, the timing of mulberry leaf extract intake is crucial for improving blood sugar control.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Ophthalmology
Meiqi Fan, Su Ah. Kim, Young-Jin Choi, Yujiao Tang, Hyun Pil Yang, Eun-Kyung Kim
Summary: This study investigated the clinical efficacy of anthocyanin oligomers for the treatment of dry eye disease. It was found that anthocyanin oligomers were safe and effective in improving various clinical indices and symptoms of mild-to-moderate dry eye patients. Oral administration of anthocyanin oligomers can enhance therapeutic effect and improve patients' quality of life.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Nutrition & Dietetics
Pariyarath Sangeetha Thondre, Helen Lightowler, Lis Ahlstrom, Andrew Gallagher
Summary: This study conducted a double-blind, randomized, placebo-controlled, crossover trial to investigate the effects of mulberry leaf extract on glycaemic and insulinaemic responses to sucrose in healthy individuals. The results showed that mulberry leaf extract significantly reduced both glycaemic and insulinaemic responses, making it a potential ingredient for maintaining healthy blood glucose levels.
NUTRITION & METABOLISM
(2021)
Article
Microbiology
N. Mutoh, I. Kakiuchi, A. Hiraku, N. Iwabuchi, K. Kiyosawa, K. Igarashi, M. Tanaka, M. Nakamura, M. Miyasaka
Summary: The effects of heat-killed Lactobacillus helveticus MCC1848 on daily mood states in healthy young adults were investigated. The results showed that daily consumption of heat-killed L. helveticus MCC1848 significantly improved positive mood states, such as friendliness and relaxation, but had no significant effects on negative mood states. These findings suggest that daily consumption of heat-killed L. helveticus MCC1848 is safe and has the potential to improve positive mood states.
BENEFICIAL MICROBES
(2023)
Article
Nutrition & Dietetics
Jenny E. Gunton, Christian M. Girgis, Timothea Lau, Mauro Vicaretti, Lindy Begg, Victoria Flood
Summary: The study conducted a trial of vitamin C therapy for chronic foot ulcers at the Foot Wound Clinic, showing significant improvement in ulcer healing with vitamin C treatment and no amputations needed in the vitamin C group. Further research is needed to determine the effectiveness threshold for serum vitamin C levels and the possibility of better or lesser responding subgroups.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Marshall G. Miller, Nopporn Thangthaeng, Grant A. Rutledge, Tammy M. Scott, Barbara Shukitt-Hale
Summary: Research has shown that dietary supplementation with strawberries can improve cognitive functions in rodent models of aging, and a study on older adults found that it can improve aspects of cognition but not gait or balance. Further studies with larger sample sizes and longer follow-up are needed to confirm these findings.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Clinical Neurology
Karin Ried, Tasnuva Tamanna, Sonja Matthews, Avni Sali
Summary: This study aimed to assess the tolerability and effectiveness of Entoura-10:15 medicinal cannabis oil on sleep in adults with insomnia. The results showed that the medicinal cannabis oil was well tolerated and effective in improving sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, General & Internal
Raymond Hang Wun Li, Sue Seen Tsing Lo, Kristina Gemzell-Danielsson, Carol Ho Yi Fong, Pak Chung Ho, Ernest Hung Yu Ng
Summary: This study found that co-administration of oral piroxicam 40 mg with levonorgestrel improved the efficacy of emergency contraception. The use of piroxicam could be considered in clinical settings where levonorgestrel emergency contraception is the chosen option.
Article
Psychology, Clinical
Rita Baiao, Liliana P. Capitao, Cameron Higgins, Michael Browning, Catherine J. Harmer, Philip W. J. Burnet
Summary: This study found that taking probiotics can improve emotional processing and vigilance to neutral faces, reduce reward learning and interference word recall, and lower depression scores. However, these changes were not correlated with changes in emotional processing.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicolino Ruperto, Hermine Brunner, Olga Synoverska, Tracy Ting, Carlos Abud Mendoza, Alberto Spindler, Yulia Vyzhga, Katherine Marzan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Rita Jerath, Daniel J. Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Yonatan Butbul Aviel, Vyacheslav Chasnyk, Melissa Lerman, Kabita Nanda, Heinrike Schmeling, Heather Tory, Yosef Uziel, Diego O. Viola, Holly B. Posner, Keith S. Kanik, Ann Wouters, Cheng Chang, Richard Zhang, Irina Lazariciu, Ming-Ann Hsu, Ricardo M. Suehiro, Alberto Martini, Daniel J. Lovell
Summary: The trial showed that tofacitinib is an effective treatment for patients with polyarticular course JIA. New oral therapies are particularly relevant for children and adolescents, who might prefer to avoid injections.
Article
Clinical Neurology
Adrian L. Lopresti, Stephen J. Smith, Peter D. Drummond
Summary: This study validated and extended previous findings on the sleep-enhancing effects of saffron supplementation in adults with unsatisfactory sleep. Saffron supplementation was associated with significant improvements in sleep quality ratings, mood ratings, insomnia symptoms, and insomnia classifications compared to placebo, with similar effects for two different doses of saffron administered.
Article
Nutrition & Dietetics
Adrian L. Lopresti, Stephen J. Smith, Shavon Jackson-Michel, Timothy Fairchild
Summary: Curcumin may have the potential to alleviate pain in knee osteoarthritis, as it significantly reduces pain scores and improves physical function. However, further studies with longer duration, varying doses, different curcumin extracts, and more objective outcome measures are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Liangyu He, Yan Xing, Xinxiu Ren, Mengjiao Zheng, Shiqiang Yu, Yinbo Wang, Zhilong Xiu, Yuesheng Dong
Summary: This study evaluated the effect and mechanism of mulberry leaf extract (MLE) in alleviating metabolic syndrome (MS). The results showed that MLE improved lipid metabolism through multiple mechanisms, including inhibiting lipid synthesis and promoting lipid decomposition, as well as affecting gut microbiota composition and short-chain fatty acid production, thereby alleviating lipid accumulation.
Article
Gastroenterology & Hepatology
Ciaran P. Kelly, Joseph A. Murray, Daniel A. Leffler, Daniel R. Getts, Adam C. Bledsoe, Glennda Smithson, M. Roy First, Amy Morris, Michael Boyne, Adam Elhofy, Tsung-Teh Wu, Joseph R. Podojil, Stephen D. Miller
Summary: TAK-101, a gluten protein encapsulated in nanoparticles, demonstrated promising results in reducing gluten-induced immune activation in patients with CeD, suggesting a novel approach for other immune-mediated diseases.
Article
Medicine, General & Internal
Sube Banerjee, Juliet High, Susan Stirling, Lee Shepstone, Ann Marie Swart, Tanya Telling, Catherine Henderson, Clive Ballard, Peter Bentham, Alistair Burns, Nicolas Farina, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O'Brien, Annabel Price, Alan J. Thomas, Naji Tabet
Summary: This study evaluated the efficacy and safety of mirtazapine, an antidepressant, for treating agitation in patients with dementia. The findings showed that mirtazapine did not reduce agitation symptoms compared to placebo, and there was a potentially higher mortality rate associated with mirtazapine use.
Article
Transplantation
Yejin Kim, Jeonggyu Kang, Yoosoo Chang, Young Youl Hyun, Kyu-Beck Lee, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: This study evaluated the association between coronary artery calcium scores (CACSs) and the development of chronic kidney disease (CKD). The results showed that higher CACS was progressively associated with an increased risk of CKD, indicating that individuals with higher CACS have a higher risk of developing CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Endocrinology & Metabolism
Josh Bilson, Jaswinder K. Sethi, Christopher D. Byrne
Summary: This review discusses the recent evidence of distinct white adipocyte subpopulations in white adipose tissue and how these subpopulations may be altered with increasing adiposity and/or metabolic disease. Studies have shown that these subtypes are potentially functionally distinct and may play different roles in white adipose tissue function and obesity-associated metabolic diseases.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Endocrinology & Metabolism
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Yejin Kim, Hyun-Suk Jung, Jeonggyu Kang, In Young Choi, Chan-won Kim, Hyungseok Oh, Sarah H. Wild, Christopher D. Byrne
Summary: This study evaluated the effect of changes in prediabetes on subclinical atherosclerosis and found that persistence of prediabetes or progression to diabetes increased the risk of coronary artery calcification.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Feng Gao, De-Chan Lu, Tian-Lei Zheng, Shi Geng, Jun-Cheng Sha, Ou-Yang Huang, Liang-Jie Tang, Pei-Wu Zhu, Yang-Yang Li, Li-Li Chen, Giovanni Targher, Christopher D. Byrne, Zu-Fang Huang, Ming-Hua Zheng
Summary: This study developed a rapid and practical tool for non-invasive identification of NASH by using SERS spectra and neural network approaches, which outperformed existing serum markers in distinguishing NASH.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Tae Kyung Yoo, Mi Yeon Lee, Seong Hwan Kim, Ming-Hua Zheng, Giovanni Targher, Christopher D. Byrne, Ki-Chul Sung
Summary: A cohort study suggests that metabolic dysfunction-associated fatty liver disease (MAFLD) predicts cardiovascular disease (CVD) mortality better than non-alcoholic fatty liver disease (NAFLD).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Chanmin Kim, Sarah H. Wild, Christopher D. Byrne
Summary: There is a relationship between a previous history of gestational diabetes mellitus (pGDM) and the risk of nonalcoholic fatty liver disease (NAFLD). However, insulin resistance and diabetes explain less than 10% of this association.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Nick A. A. Francis, Taeko Becque, Merlin Willcox, Alastair D. D. Hay, Mark Lown, Richard Clarke, Beth Stuart, Lucy Yardley, Michael Moore, Joelle Houriet, Paul Little
Summary: This study found that non-pharmaceutical interventions such as wearing face masks, practicing social distancing, and frequent handwashing have strong protective effects against COVID-19 infection.
Article
Endocrinology & Metabolism
Alessandro Mantovani, Alessandro Csermely, Antonio Taverna, Davide Cappelli, Giovanni Benfari, Stefano Bonapace, Christopher D. Byrne, Giovanni Targher
Summary: The presence and severity of metabolic dysfunction-associated fatty liver disease (MAFLD) is strongly associated with an increased risk of supraventricular and ventricular tachyarrhythmias in patients with type 2 diabetes mellitus (T2DM), especially in those with severe fibrosis indicated by FIB-4 index.
DIABETES & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Giovanni Targher, Alessandro Mantovani, Christopher D. Byrne
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Andrew Collier, Christopher Curran, Lyall Cameron, Sarah H. Wild, Christopher D. Byrne
Summary: This retrospective cohort study investigated the distribution of fibrosis risk scores (FIB4, NFS, and APRI) and their association with all-cause mortality in individuals with type 2 diabetes. The results showed that all three fibrosis risk scores were positively associated with all-cause mortality, with higher relative risks in younger individuals. Effective interventions are needed to reduce excess mortality in individuals at high risk of liver fibrosis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Miriam Santer, Megan Lawrence, Susanne Renz, Zina Eminton, Beth Stuart, Tracey H. Sach, Sarah Pyne, Matthew J. Ridd, Nick Francis, Irene Soulsby, Karen Thomas, Natalia Permyakova, Paul Little, Ingrid Muller, Jacqui Nuttall, Gareth Griffiths, Kim S. Thomas, Alison M. Layton
Summary: This study assessed the effectiveness of oral spironolactone for acne vulgaris in adult women. The results showed that spironolactone had significant improvement in acne symptoms and quality of life compared to placebo at 12 weeks and 24 weeks, with no serious adverse reactions reported. This suggests that spironolactone is a useful alternative to oral antibiotics for women with acne.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Dan-Qin Sun, Giovanni Targher, Christopher D. Byrne, David C. Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T. Long, Mehmet Kanbay, Mindie H. Nguyen, Sankar D. Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A. Gani, Pierluigi Marzuillo, Jerome Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Mendez-Sanchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G. Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng
Summary: A multidisciplinary panel of 50 international experts reached a consensus on the link between MAFLD and CKD using a Delphi-based approach. This consensus statement provides guidance on the epidemiology, mechanisms, management, and treatment of MAFLD and CKD, as well as the relationship between the severity of MAFLD and the risk of CKD, establishing a framework for early prevention and management of these two common and interconnected diseases.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Integrative & Complementary Medicine
Xiao-Yang Hu, Ru-Yu Xia, Michael Moore, Beth Stuart, Ling-Zi Wen, Bertrand Graz, Lily Lai, Jian-Ping Liu, Yu -Tong Fei, Merlin Willcox
Summary: This study aimed to identify the use of various treatments and their association with the use of antibiotics and patient reported clinical recovery in Chinese adults with acute cough. An online survey was conducted to collect data on sociodemographic and clinical characteristics, treatments received, and perceived changes in symptoms among adults with recent acute cough. The study found a high proportion of inappropriate use of antibiotics for the treatment of simple acute cough.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Infectious Diseases
David Gillespie, Mandy Wootton, Ruby Ray, Philip C. Calder, Tin Man Mandy Lau, Eleri Owen-Jones, Rachel Lowe, Leanne Davies, Jennifer Richards, Kerenza Hood, Vivian Castro-Herrera, Jane Davies, Nick A. Francis, F. D. Richard Hobbs, Mark Lown, Michael Moore, Victoria Shepherd, Christopher C. Butler
Summary: This study described the prevalence of potentially clinically relevant gut pathogens and their associations with the carriage of resistant organisms in UK care home residents. The findings highlighted the significant levels of antimicrobial-resistant organisms in the residents' stool, emphasizing the importance of enhanced infection control practices and antimicrobial stewardship programs.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Miriam Santer, Megan Lawrence, Susanne Renz, Zina Eminton, Beth Stuart, Tracey H. Sach, Sarah Pyne, Matthew J. Ridd, Nick Francis, Irene Soulsby, Karen Thomas, Natalia Permyakova, Paul Little, Ingrid Muller, Jacqui Nuttall, Gareth Griffiths, Kim S. Thomas, Alison M. Layton
Summary: Oral spironolactone is effective in improving symptoms and quality of life for adult women with acne vulgaris, with better efficacy compared to oral antibiotics.
BMJ-BRITISH MEDICAL JOURNAL
(2023)