Article
Urology & Nephrology
Scott Davis, Sumit Mohan
Summary: Patients who experience kidney transplant failure often face complex management decisions due to limited high-quality data, leading to variable and suboptimal practice patterns. It is essential to address critical gaps in knowledge to provide optimal care for these patients.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bayan Hassan Banimfreg, Hussam Alshraideh, Abdulrahim Shamayleh, Adnane Guella, Mohammad Harb Semreen, Mohammad Tahseen Al Bataineh, Nelson C. Soares
Summary: This study utilizes metabolomics to identify blood biomarkers differentiating diabetic kidney disease (DKD) from non-diabetic kidney disease in the Emirati population. Analysis of blood samples from hemodialysis subjects revealed significant metabolites and metabolic pathways associated with clinically confirmed diabetic status and HbA1c values.
Article
Biochemistry & Molecular Biology
Hitoshi Iwamoto, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Shigeyuki Kawachi, Makoto Sunamura, Masahiro Sugimoto
Summary: Kidney biopsy is commonly used to diagnose kidney transplant dysfunction. In this study, capillary electrophoresis-mass spectrometry was used to analyze the biofluids of transplant recipients. Metabolomics analyses revealed significant differences in the metabolomic profiles of the different groups, particularly in arginine biosynthesis and purine metabolism in plasma samples. Different types of kidney disorders also showed distinct metabolomic profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Charat Thongprayoon, Ivan Vuckovic, Lisa E. Vaughan, Slobodan Macura, Nicholas B. Larson, Matthew R. D'Costa, John C. Lieske, Andrew D. Rule, Aleksandar Denic
Summary: This study compared the urine samples of first-time stone formers and controls using high-resolution H-1 nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis. The results showed differences in urine metabolites and chemistries between the two groups, providing insights into the pathogenesis of kidney stones.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Xin Li, Ruoying Li, Bingqing Ji, Lili Zhao, Junpeng Wang, Tianzhong Yan
Summary: This study investigated the metagenomic and metabolic patterns of gut microbiota in patients with antibody-mediated rejection (AMR) after kidney transplantation. The findings provide a comprehensive understanding of the correlation between AMR and gut microbiota, which is important for the etiological and diagnostic study of AMR after kidney transplantation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Luc Colas, Anne-Lise Royer, Justine Massias, Axel Raux, Melanie Chesneau, Clarisse Kerleau, Pierrick Guerif, Magali Giral, Yann Guitton, Sophie Brouard
Summary: This is an open access article published by Elsevier B.V., under the copyright of the authors and licensed under CC BY-NC-ND.
Article
Multidisciplinary Sciences
Shambavi Ganesh, Thomas Hu, Eric Woods, Mayar Allam, Shuangyi Cai, Walter Henderson, Ahmet F. Coskun
Summary: Researchers presented a three-dimensional spatially resolved metabolomic profiling framework (3D-SMF) to map out the spatial organization of metabolic fragments and protein signatures in immune cells of human tonsils. Various analyses were conducted to explore the relationships between metabolic and cellular features, revealing spatially distinct lipidomic fragment distributions in lymphatic tissue. The 3D-SMF pipeline impacts the study of immune cells in health and disease.
Article
Biochemical Research Methods
Hongying Zhu, Qianqian Li, Tiepeng Liao, Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang, Wei Xiong
Summary: SLMS integrates lysosomal patch-clamp recording and induced nanoESI/MS for concurrent metabolic and electrophysiological profiling of individual enlarged lysosomes. This technique has been validated for accuracy and reliability, enabling the classification of lysosomes into subpopulations based on their chemical and biological differences in various cell types. SLMS has the potential to investigate heterogeneous lysosomal metabolic changes during physiological and pathological processes.
Article
Physiology
Ram B. Khattri, Kyoungrae Kim, Erik M. Anderson, Brian Fazzone, Kenneth C. Harland, Qiongyao Hu, Victoria R. Palzkill, Tomas A. Cort, Kerri A. O'Malley, Scott A. Berceli, Salvatore T. Scali, Terence E. Ryan
Summary: This study investigated the metabolomic changes in limb muscle following arteriovenous fistula (AVF) placement in mice, and found that AVF creation resulted in an energetic crisis and myosteatosis, which were strongly associated with limb function.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Joanna Niziol, Valerie Copie, Brian P. Tripet, Leonardo B. Nogueira, Katiane O. P. C. Nogueira, Krzysztof Ossolinski, Adrian Arendowski, Tomasz Ruman
Summary: This study aimed to perform metabolomic and elemental profiling of human kidney cancer and normal tissue in order to evaluate cancer biomarkers. The results identified five potential tissue biomarkers of kidney cancer and suggested their potential for clinical prognosis and diagnosis.
Article
Multidisciplinary Sciences
Joanna Niziol, Krzysztof Ossolinski, Aneta Plaza-Altamer, Artur Kolodziej, Anna Ossolinska, Tadeusz Ossolinski, Tomasz Ruman
Summary: In this study, metabolomic profiling was used to identify serum metabolites that can differentiate bladder cancer patients from non-cancer controls. The results showed that twenty-seven metabolites can distinguish between bladder cancer patients and controls, and twenty-three metabolites can differentiate between different grades and stages of bladder cancer. This suggests that measuring serum metabolites could provide a less invasive diagnostic method for bladder cancer detection and management of recurrent disease.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Renato Itamar Duarte Fonseca, Leociley Rocha Alencar Menezes, Arquimedes Paixao Santana-Filho, Elberth Manfron Schiefer, Roberto Pecoits-Filho, Andrea Emilia Marques Stinghen, Guilherme Lanzi Sassaki
Summary: Chronic kidney disease is a global public health issue, and this study aimed to identify changes in the metabolomic profile that occur as the disease progresses. Using NMR spectroscopy, plasma samples from CKD patients were evaluated and significant differences in metabolomic profiles were found compared to a control group. Principal component analysis allowed for the clustering of CKD patients and control subjects into different groups, and various metabolic pathways were found to be involved in CKD progression.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Medicine, General & Internal
Rita Leal, Clara Pardinhas, Antonio Martinho, Helena Oliveira Sa, Arnaldo Figueiredo, Rui Alves
Summary: The management of patients with failed kidney allograft is complex and requires attention to complications, immunosuppression withdrawal, retransplant, and other issues. Recent studies have shown a growing interest in improving outcomes for these patients through multidisciplinary programs and personalized approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Long Miao, Boshen Wang, Juan Zhang, Lihong Yin, Yuepu Pu
Summary: This study identified potential metabolic biomarkers associated with NIHL using metabolomics analysis and revealed several metabolic pathways related to NIHL. Further research indicated that the autophagy signal pathway may be involved in the occurrence and development of NIHL.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Immunology
Yan-zhong Han, Zhi-tao Ma, Ming-xi Zhou, Ming Niu, Xu Zhao, Yu-ming Guo, Xin-hua Song, Ya-wen Lu, Zhao-fang Bai, Zhen Li, Han Gao, Yong-kang Zhao, Jia-bo Wang, Xiao-he Xiao, Jing Jing
Summary: By using metabolomics analysis, it has been found that drug-induced liver injury with autoantibodies may not be a homogeneous group in terms of pathogenesis, including a subset with autoimmune hepatitis tendencies. This finding calls for further investigation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Surgery
Martina Taborelli, Diego Serraino, Claudia Cimaglia, Lucrezia Furian, Luigi Biancone, Ghil Busnach, Paola Todeschini, Nicola Bossini, Maurizio Iaria, Maria R. Campise, Massimiliano Veroux, Franco Citterio, Andrea Ambrosini, Vincenzo Cantaluppi, Margherita Mangino, Francesco Pisani, Giuseppe Tisone, Marco Fiorentino, Davide Argiolas, Flavia Caputo, Pierluca Piselli
Summary: This study found that cancer has a significant impact on the risk of death with a functioning graft in kidney transplant recipients. Those with cancer had a 3.31 times higher risk of death compared to recipients without cancer. Different types of cancer showed varying levels of risk, with the effect being more pronounced within the first year following cancer diagnosis.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Immunology
Vera Usuelli, Cristian Loretelli, Andy Joe Seelam, Ida Pastore, Francesca D'Addio, Moufida Ben Nasr, Paolo Fiorina
Summary: This review emphasizes the role of novel soluble mediators in the activation of innate immunity during solid allograft rejection and discusses emerging strategies to alleviate rejection events. Understanding the activation of the innate immune system may help mitigate solid allograft rejection and improve outcomes for transplanted recipients.
Review
Endocrinology & Metabolism
Andrea Coppola, Giada Zorzetto, Filippo Piacentino, Valeria Bettoni, Ida Pastore, Paolo Marra, Laura Perani, Antonio Esposito, Francesco De Cobelli, Giulio Carcano, Federico Fontana, Paolo Fiorina, Massimo Venturini
Summary: This review summarized the most frequently used imaging animal models in translational and experimental medicine, and their implications in fields such as diabetes mellitus.
ACTA DIABETOLOGICA
(2022)
Review
Oncology
Samuele Ghezzo, Carolina Bezzi, Luca Presotto, Paola Mapelli, Valentino Bettinardi, Annarita Savi, Ilaria Neri, Erik Preza, Ana Maria Samanes Gajate, Francesco De Cobelli, Paola Scifo, Maria Picchio
Summary: This study reviews the clinical applications of radiomics in prostate cancer management, including detection, clinical significance assessment, biochemical recurrence prediction, radiation-therapy outcome prediction, metastases detection and prediction, and extra-prostatic extension prediction. Seventy-six studies were analyzed qualitatively, showing promising results in discriminating between healthy tissue and cancer, as well as between low- and high-risk prostate cancer. Standardization of radiomics methods and replication of results in large and independent cohorts are needed before clinical use.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Gabriele Capurso, Nicolo Pecorelli, Alice Burini, Giulia Orsi, Diego Palumbo, Marina Macchini, Roberto Mele, Francesco de Cobelli, Massimo Falconi, Paolo Giorgio Arcidiacono, Michele Reni
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive disease that can alter the nutritional status of patients, leading to malnutrition and muscle wasting. The ideal way to measure these changes and identify them early to prevent complications or treatment discontinuation is still relatively unexplored. Nutritional assessment is crucial in PDAC patients, and bioimpedance vector analysis and radiological assessment of body composition appear to be more accurate in predicting clinical outcomes and postoperative complications.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Article
Oncology
Andrea Galli, Michele Colombo, Carmine Prizio, Giulia Carrara, Francesca Lira Luce, Pier Luigi Paesano, Giovanna Della Vecchia, Leone Giordano, Stefano Bondi, Michele Tulli, Davide Di Santo, Aurora Mirabile, Francesco De Cobelli, Mario Bussi
Summary: The study demonstrates the value of ultrasound scans and CT/MRI in estimating skeletal muscle mass and identifying sarcopenic patients in a cohort of head and neck cancer patients. These methods can also serve as predictors of major surgical morbidity and aid in pre-habilitation strategies to reduce postoperative complications.
Article
Endocrinology & Metabolism
Francesca D'Addio, Gianmarco Sabiu, Vera Usuelli, Emma Assi, Ahmed Abdelsalam, Anna Maestroni, Andy Joe Seelam, Moufida Ben Nasr, Cristian Loretelli, Davide Mileto, Giada Rossi, Ida Pastore, Laura Montefusco, Paola S. Morpurgo, Laura Plebani, Antonio Rossi, Enrica Chebat, Andrea M. Bolla, Maria Elena Lunati, Chiara Mameli, Maddalena Macedoni, Spinello Antinori, Stefano Rusconi, Maurizio Gallieni, Cesare Berra, Franco Folli, Massimo Galli, Maria Rita Gismondo, Gianvincenzo Zuccotti, Paolo Fiorina
Summary: This study evaluated the safety, immunogenicity, and glycometabolic effects of the SARS-CoV-2 mRNA vaccines in patients with type 1 diabetes (T1D). The findings showed that although T1D patients had an increase in antibody titers after vaccination, most patients did not show an increase in the specific cytotoxic immune response to SARS-CoV-2. Additionally, a reduced secretion of cytokines was observed in T1D patients after vaccination, but no glycometabolic alterations were evident.
Letter
Endocrinology & Metabolism
Francesca D'Addio, Paolo Fiorina
Editorial Material
Biochemistry & Molecular Biology
Francesca D'Addio, Laura Montefusco, Maria Elena Lunati, Ida Pastore, Emma Assi, Adriana Petrazzuolo, Virna Marin, Chiara Bruckmann, Paolo Fiorina
Summary: Apoptotic pathways play a vital role in maintaining tissue and organ homeostasis. Dysregulation of cell death signaling can lead to various diseases, including cancer and chronic degenerative diseases. Therefore, targeting apoptotic factors has become a focus of research, and the IGFBP3/TMEM219 apoptotic axis has shown promising results in disease conditions such as intestinal disorders and diabetes.
Article
Endocrinology & Metabolism
Laura Montefusco, Ida Pastore, Maria Elena Lunati, Paolo Fiorina
Article
Pharmacology & Pharmacy
Cristian Loretelli, Ida Pastore, Maria Elena Lunati, Ahmed Abdelsalam, Vera Usuelli, Emma Assi, Emma Fiorina, Lara Loreggian, Hari Baskar Balasubramanian, Yanan Xie, Jun Yang, Basset El Essawy, Laura Montefusco, Francesca D'Addio, Moufida Ben Nasr, Paolo Fiorina
Summary: The purpose of this review is to elucidate the role of ATP-mediated signaling in the immunological events related to type 1 diabetes (T1D). Recent findings suggest a potential role for eATP in early steps of T1D onset and of allograft rejection. Drugs targeting purinergic signaling have been employed to abrogate lymphocyte activation and differentiation, representing a potential treatment for T1D and long-term islet allograft function.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Adriana Petrazzuolo, Gianmarco Sabiu, Emma Assi, Anna Maestroni, Ida Pastore, Maria Elena Lunati, Laura Montefusco, Cristian Loretelli, Giada Rossi, Moufida Ben Nasr, Vera Usuelli, Yanan Xie, Hari Baskar Balasubramanian, Monica Zocchi, Basset El Essawy, Jun Yang, Francesca D'Addio, Paolo Fiorina
Summary: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease in diabetic patients, with its prevalence increasing globally. It is characterized by histological alterations primarily affecting the glomerular filtration unit, resulting in urinary albumin-to-creatinine ratio elevation and estimated glomerular filtration rate reduction. This review highlights recent advances in understanding the cellular and molecular mechanisms underlying DKD and discusses potential therapeutic targets for future applications.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
G. Bendotti, L. Montefusco, I. Pastore, E. Lazzaroni, M. E. Lunati, P. Fiorina
Summary: This review discusses the anti-inflammatory and immunological properties of SGLT-2 inhibitors and how these properties contribute to their beneficial effects in diabetes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Sabrina Gloria Giulia Testoni, Claudia Minici, Elisa Benetti, Francesca Clemente, Daniela Boselli, Clara Sciorati, Lucia De Monte, Maria Chiara Petrone, Markus Enderle, Walter Linzenbold, Maria Pia Protti, Angelo Manfredi, Francesco De Cobelli, Michele Reni, Massimo Falconi, Gabriele Capurso, Paolo Giorgio Arcidiacono, Emanuel Della-Torre
Summary: Thermal ablation under endoscopic ultrasound (EUS)-guidance has shown potential to enhance immune response in pancreatic ductal adenocarcinoma (PDAC). In a recent trial, EUS-guided ablation with HybridTherm Probe (HTP) in combination with chemotherapy improved disease progression compared to chemotherapy alone. This study explored the effects of EUS-HTP on systemic immune response in PDAC and found that it selectively affected immunological predictors of poor outcome.
Article
Endocrinology & Metabolism
Francesca D'Addio, Ida Pastore, Cristian Loretelli, Alessandro Valderrama-Vasquez, Vera Usuelli, Emma Assi, Chiara Mameli, Maddalena Macedoni, Anna Maestroni, Antonio Rossi, Maria Elena Lunati, Paola Silvia Morpurgo, Alessandra Gandolfi, Laura Montefusco, Andrea Mario Bolla, Moufida Ben Nasr, Stefania Di Maggio, Lisa Melzi, Giovanni Staurenghi, Antonio Secchi, Stefania Bianchi Marzoli, Gianvincenzo Zuccotti, Paolo Fiorina
Summary: This study developed an eye-tracking-based test to evaluate oculomotor function in patients with type 1 diabetes and found abnormalities in the oculomotor system in these patients. Among the eye-tracking tasks, 11% of parameters were significantly altered in patients with type 1 diabetes, with a higher proportion of abnormalities observed in the Wideness and Resistance parameters.
ACTA DIABETOLOGICA
(2022)