Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition

Structure ofBacillus subtilisγ-glutamyltranspeptidase in complex with acivicin: diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue

(2014) Tomoyo Ida et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

(2013) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis of substrate selectivity of Δ1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain length

(2013) Travis A. Pemberton et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis

(2013) Jiesi Xu et al.   HEPATOLOGY

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

(2013) Megan H. Wright et al.   Nature Chemistry

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

(2012) Jürgen Eirich et al.   Molecular BioSystems

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

(2011) Paola Marcato et al.   CELL CYCLE

Aldehyde dehydrogenases and cell proliferation

(2011) G. Muzio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

(2010) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds

(2010) Ronald Orth et al.   CHEMICAL COMMUNICATIONS

Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme

(2010) D. Stagos et al.   DRUG METABOLISM AND DISPOSITION

Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis†‡

(2009) Kristin Williams et al.   BIOCHEMISTRY

Structural biology of proline catabolism

(2008) John J. Tanner   AMINO ACIDS

Activity-based probes as a tool for functional proteomic analysis of proteases

(2008) Marko Fonović et al.   Expert Review of Proteomics

Crystal Structures of Escherichia coli γ-Glutamyltranspeptidase in Complex with Azaserine and Acivicin: Novel Mechanistic Implication for Inhibition by Glutamine Antagonists

(2008) Kei Wada et al.   JOURNAL OF MOLECULAR BIOLOGY

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

(2008) Jan S Moreb et al.   Molecular Cancer