Article
Multidisciplinary Sciences
Sagar P. Bapat, Caroline Whitty, Cody T. Mowery, Yuqiong Liang, Arum Yoo, Zewen Jiang, Michael C. Peters, Ling-juan Zhang, Ian Vogel, Carmen Zhou, Vinh Q. Nguyen, Zhongmei Li, Christina Chang, Wandi S. Zhu, Annette T. Hastie, Helen He, Xin Ren, Wenli Qiu, Sarah G. Gayer, Chang Liu, Eun Jung Choi, Marlys Fassett, Jarish N. Cohen, Jamie L. Sturgill, Laura E. Crotty Alexander, Jae Myoung Suh, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Sihao Liu, Barbara S. Nikolajczyk, In-Kyu Lee, Emma Guttman-Yassky, K. Mark Ansel, Prescott G. Woodruff, John Fahy, Dean Sheppard, Richard L. Gallo, Chun Jimmie Ye, Ronald M. Evans, Ye Zheng, Alexander Marson
Summary: Obesity can disrupt immune responses and alter the effectiveness of immunotherapies by changing T cell immune reactions and decreasing the activity of PPAR gamma in Th2 cells.
Article
Endocrinology & Metabolism
Sarah Heimovics, Nathan Rubin, Morgan Ford
Summary: The study investigates the role of adrenal dehydroepiandrosterone (DHEA) in regulating singing behavior in non-breeding male European starlings. It demonstrates that DHEA implants significantly increase undirected singing behavior and modulate dopaminergic neurotransmission. Overall, the study expands the social behavior functions of DHEA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Toxicology
Anastasiia Zuieva, Suzan Can, Franziska Boelke, Stefanie Reuter, Sebastian Schattscheider, Elfi Toepfer, Anika Westphal, Ralf Mrowka, Stefan Woelfl
Summary: Microfluidic tissue culture and organ-on-a-chip models provide efficient tools for drug testing and have the potential to replace animal testing. This study introduces a novel experimental setup that allows continuous recording of luciferase reporter gene expression to monitor drug action.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Psychiatry
Luke J. Norman, Gustavo Sudre, Marine Bouyssi-Kobar, Wendy Sharp, Philip Shaw
Summary: This study suggests that specific brain region connectivity plays a role in the response of patients with attention deficit hyperactivity disorder to psychostimulant medication at different ages.
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Correction
Psychiatry
Jung-Chi Chang, Hsiang-Yuan Lin, Jinglei Lv, Wen-Yih Issac Tseng, Susan Shur-Fen Gau
Summary: An amendment to the paper has been published and is accessible through the original article.
Article
Psychiatry
Jung-Chi Chang, Hsiang-Yuan Lin, Junglei Lv, Wen-Yih Issac Tseng, Susan Shur-Fen Gau
Summary: Our study found that regional gray matter volumes in the striatum and precuneus play a critical role in mediating treatment responses in individuals with ADHD, especially the left putamen and precuneus. The machine learning approach identified volumetric information among these regions could predict clinical responses to methylphenidate in individuals with ADHD.
Article
Biochemistry & Molecular Biology
Bhagwat Prasad Dewangan, Arunima Gupta, Rajan Kumar Sah, Shouvik Das, Sandeep Kumar, Saikat Bhattacharjee, Prashant Anupama-Mohan Pawar
Summary: A type of oligosaccharide in plant cell walls can act as an elicitor to trigger immune responses and alter the composition of the cell walls and hormone levels.
PLANT MOLECULAR BIOLOGY
(2023)
Article
Genetics & Heredity
Brandon A. Heidinger, Jameason D. Cameron, Regis Vaillancourt, Michael De Lisio, Matthew Ngu, Giorgio A. Tasca, Livia Chyurlia, Eric Doucet, Steve Doucette, Ana Maria Obregon Rivas, Gary S. Goldfield
Summary: This study found that dopaminergic gene polymorphisms do not predict response to behavioral intervention for binge-eating disorder, and are not associated with anthropometrics or binge frequency. Future research should explore a wider range of dopaminergic polymorphisms and other candidate genes targeting different neurotransmitter systems for both behavioral and pharmacological-based treatments.
Article
Ecology
William H. McDowell, Jody D. Potter
Summary: Soil solution chemistry is sensitive to disturbance but resilient, with a return to baseline after 12-18 months. Canopy loss and detrital inputs result in increased nitrate concentrations, while potassium increases following drought and hurricanes. Phosphorus only increases following hurricanes in plots that received previous manipulation.
Article
Soil Science
Cong Wang, Zongming Li, Jianlin Shen, Yanyan Li, Dan Chen, Nanthi Bolan, Yong Li, Jinshui Wu
Summary: The application of biochar can greatly increase the abundance of diazotrophs in paddy fields, especially in double rice paddies.
BIOLOGY AND FERTILITY OF SOILS
(2023)
Article
Plant Sciences
Miyuki T. Nakata, Shingo Sakamoto, Nuoendagula, Shinya Kajita, Nobutaka Mitsuda
Summary: The specific transcription factor ERF041-VP16 can increase cell wall thickness, enhance cell wall content, alter lignin composition and deposition, thereby improving biomass yield.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Behavioral Sciences
T. C. Peixoto, E. G. Moura, P. N. Soares, V. S. T. Rodrigues, S. Claudio-Neto, E. Oliveira, A. C. Manhaes, P. C. Lisboa
Summary: Nicotine exposure during lactation in rats leads to increased food intake, preference for high-sucrose diet, and higher anxiety-like behavior in female offspring. Additionally, changes in the dopaminergic system and hypothalamic leptin signaling pathway were observed, making them more susceptible to food addiction and obesity.
Article
Clinical Neurology
Yuji Takahara, Toyosaku Ota, Yoko Nakanishi, Shotaro Ueda, Peter Jurica, Zbignew R. Struzik, Kohei Nishitomi, Junzo Iida, Toshifumi Kishimoto, Andrzej Cichocki, Minoru Hasegawa, Koichi Ogawa
Summary: This study explores EEG markers for estimating the therapeutic efficacy of medication in ADHD patients. It found that changes in theta band power in the right temporal areas, alpha in the left occipital and frontal areas, and beta in the left frontal areas can differentiate between good and poor responders to MPH treatment. It also showed that good responders had improvements in several coherence measures after treatment.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Health Care Sciences & Services
Claire T. Than, Bevanne Bean-Mayberry, C. Amanda Schweizer, Martin Lee, Catherine Chanfreau-Coffinier, Kimberly Clair, Alison B. Hamilton, Melissa M. Farmer
Summary: This study aimed to examine the impact of repeated screening for tobacco use on receiving smoking cessation treatment among women Veteran population. The findings suggest that repeated screening is associated with higher probabilities of receiving prescription for smoking cessation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Oncology
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frias, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Soren Buus, Allan Randrup Thomsen, Morten Nielsen, Kristoffer Staal Rohrberg, Kjeld Schmiegelow, Daniela De Zio
Summary: This study used the drug 6TG to induce mutations in tumor cells and increase the level of neoepitopes, enhancing the immune response. 6TG exposure increased tumor mutational burden and reshaped the tumor microenvironment, making the tumors more responsive to immune-checkpoint blockade.
Review
Neurosciences
Martine Hoogman, Daan van Rooij, Marieke Klein, Premika Boedhoe, Iva Ilioska, Ting Li, Yash Patel, Merel C. Postema, Yanli Zhang-James, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Tobias Banaschewski, Claiton H. D. Bau, Marlene Behrmann, Mark A. Bellgrove, Daniel Brandeis, Silvia Brem, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Francisco X. Castellanos, David Coghill, Annette Conzelmann, Eileen Daly, Christine Deruelle, Ilan Dinstein, Sarah Durston, Christine Ecker, Stefan Ehrlich, Jeffery N. Epstein, Damien A. Fair, Jacqueline Fitzgerald, Christine M. Freitag, Thomas Frodl, Louise Gallagher, Eugenio H. Grevet, Jan Haavik, Pieter J. Hoekstra, Joost Janssen, Georgii Karkashadze, Joseph A. King, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Jason P. Lerch, Klaus-Peter Lesch, Mario R. Louza, Beatriz Luna, Paulo Mattos, Jane McGrath, Filippo Muratori, Clodagh Murphy, Joel T. Nigg, Eileen Oberwelland-Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Mara Parellada, Paul Pauli, Kerstin J. Plessen, J. Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Philip Shaw, Tim J. Silk, Leanne Tamm, Oscar Vilarroya, Susanne Walitza, Neda Jahanshad, Stephen Faraone, Clyde Francks, Odile A. van den Heuvel, Tomas Paus, Paul M. Thompson, Jan K. Buitelaar, Barbara Franke
Summary: Neuroimaging has been extensively used to study brain structure and function in individuals with ADHD and ASD. However, there have been limitations in the current literature, such as small sample sizes and heterogeneous methods. To address these limitations, the ENIGMA-ADHD and ENIGMA-ASD working groups were established to collaborate on large-scale neuroimaging projects. The findings so far have shown overlap and unique differences in cortical structures between ASD and ADHD. Ongoing work is exploring other research questions.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Alessandra Georgette Ciancone Chama, Evgenia Shlosman, Lorenzo Mattioni, Alberto Galbusera, Giuliano Iurilli, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Abnormal tactile response is a common feature in Autism Spectrum Disorders (ASDs), and patients with Phelan-McDermid syndrome (PMS) also exhibit similar tactile response abnormalities. This study investigated the neural substrates involved in whisker-guided behaviors in Shank3b(-/-) mice, which showed deficits in texture discrimination and low responsiveness to repetitive whisker stimulation. Reduced activation in the primary somatosensory cortex (S1) and hippocampus was observed, suggesting impaired sensory processing. Resting-state fMRI further revealed decreased connectivity between S1 and the hippocampus, potentially impairing whisker-dependent cues recognition.
Article
Biochemistry & Molecular Biology
Daniel Gutierrez-Barragan, Neha Atulkumar Singh, Filomena Grazia Alvino, Ludovico Coletta, Federico Rocchi, Elizabeth De Guzman, Alberto Galbusera, Mauro Uboldi, Stefano Panzeri, Alessandro Gozzi
Summary: This study used resting-state fMRI to investigate the spontaneous brain activity in awake mice and found that it exhibits specific functional network topography and dynamic structure. These findings are important for understanding the conscious states in higher mammalian species.
Article
Multidisciplinary Sciences
Federico Rocchi, Carola Canella, Shahryar Noei, Daniel Gutierrez-Barragan, Ludovico Coletta, Alberto Galbusera, Alexia Stuefer, Stefano Vassanelli, Massimo Pasqualetti, Giuliano Iurilli, Stefano Panzeri, Alessandro Gozzi
Summary: This study investigates how inactivation of a cortical node affects brain-wide fMRI connectivity in mice, providing causal evidence that cortical inactivation can unexpectedly increase fMRI connectivity.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Antonia Kaiser, Caroline Broeder, Jessica Cohen, Linda Douw, Liesbeth Reneman, Anouk Schrantee
Summary: This study investigated the effects of methylphenidate on brain network connectivity in children and adults with ADHD and found that the effects were age-dependent. Methylphenidate decreased connectivity and centrality in subcortical regions in children, but increased these measures in adults. Interestingly, no major effects were observed in frontal regions. These findings suggest that the effects of methylphenidate treatment should be studied from a developmental perspective.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Francesca Viscido, Alessandra Georgette Ciancone Chama, Alberto Galbusera, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Sensory abnormalities are common in individuals with autism spectrum disorders (ASDs). A study found that mice lacking the ASD-associated gene Cntnap2 display altered somatosensory processing and deficits related to core symptoms of ASDs. The study suggests that these mice can serve as a reliable model to study sensory abnormalities in ASDs.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Jason G. van Genderen, Cecilia Chia, Malon Van den Hof, Henk J. M. M. Mutsaerts, Liesbeth Reneman, Dasja Pajkrt, Anouk Schrantee
Summary: Despite adoption status potentially affecting brain development, adolescents with perinatally acquired HIV still exhibit subtle lower white matter integrity.
Article
Psychiatry
Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D'Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Summary: The study suggests that D-aspartate plays an important role in neurodevelopment and functioning, and the dysmetabolism of D-aspartate is associated with neurodevelopmental disorders such as schizophrenia. Using a mouse model, the researchers found that early occurrence of D-aspartate can influence neurodevelopment and lead to social recognition memory deficits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Patricia Nora Awad, Valerio Zerbi, Erin M. M. Johnson-Venkatesh, Francesca Damiani, Marco Pagani, Marija Markicevic, Sarah Nickles, Alessandro Gozzi, Hisashi Umemori, Michela Fagiolini
Summary: The study found that there are connectivity and functional alterations in the brain of CDKL5 Deficiency Disorder (CDD) patients, which are related to cognitive deficits. The results further demonstrate the important role of CDKL5 in neuronal connectivity and cognitive function.
MOLECULAR PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Marta Chavero-Pieres, Maria Francesca Viola, Iris Appeltans, Saeed Abdurahiman, Willy Gsell, Gianluca Matteoli, Uwe Himmelreich, Guy Boeckxstaens
Summary: MRI is a reliable and reproducible tool to assess gastric emptying in mice, which can be utilized for the evaluation of gastroparesis in disease models or pharmacological compounds.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biochemistry & Molecular Biology
Urte Neniskyte, Ugne Kuliesiute, Auguste Vadisiute, Kristina Jevdokimenko, Ludovico Coletta, Senthilkumar Deivasigamani, Daina Pamedytyte, Neringa Daugelaviciene, Daiva Dabkeviciene, Emerald Perlas, Aditya Bali, Bernadette Basilico, Alessandro Gozzi, Davide Ragozzino, Cornelius T. Gross
Summary: The mature mammalian brain connectome develops through the extension and pruning of neuronal connections. Glial cells, particularly phospholipid scramblase Xkr8, play a crucial role in the elimination of unnecessary neuronal synapses and projections. This study highlights the importance of phospholipid scrambling by Xkr8 in the pruning of developing neuronal projections, with implications for brain development and hyperconnectivity.
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement M. Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. B. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Groehn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jason G. van Genderen, Charissa R. Verkade, Malon Van den Hof, Nazli Demirkaya, Anouk G. M. Schrantee, Frank D. Verbraak, Dasja Pajkrt
Summary: In this study, the neuroretinal development in perinatally HIV-infected children was found to be similar to that in healthy matched controls. Associations were also observed between retinal thickness and brain white matter microstructure.
Article
Biochemistry & Molecular Biology
Caroline Lahogue, Jean-Marie Billard, Thomas Freret, Valentine Bouet
Summary: The 5-HT6 receptors antagonist SB-271046 increases excitatory synaptic transmission and NMDAR activation at the CA3/CA1 hippocampal connections in mice. In male mice, this improvement is related to GABAAR antagonism, while in female mice it is not. Furthermore, the 5-HT6 receptors blockade has no significant effect on synaptic plasticity.