Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson’s disease

Current disease modifying approaches to treat Parkinson’s disease

(2015) Dan Lindholm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Improving the predictive value of interventional animal models data

(2015) Caroline J. Zeiss   DRUG DISCOVERY TODAY

Viral vector delivery of neurotrophic factors for Parkinson's disease therapy

(2015) Martin J. Kelly et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Trophic factors for Parkinson's disease: To live or let die

(2015) C. Warren Olanow et al.   MOVEMENT DISORDERS

Disease-modifying strategies for Parkinson's disease

(2015) Lorraine V. Kalia et al.   MOVEMENT DISORDERS

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease

(2015) Robert A. Hauser et al.   JAMA Neurology

The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease

(2015) Jackalina M. Van Kampen et al.   PLoS One

Refinement of Experimental Design and Conduct in Laboratory Animal Research

(2014) J. D. Bailoo et al.   ILAR JOURNAL

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Models of α-synuclein aggregation in Parkinson’s disease

(2014) Rosa María Giráldez-Pérez et al.   Acta Neuropathologica Communications

Modeling Parkinson's disease in monkeys for translational studies, a critical analysis

(2013) Lisa F. Potts et al.   EXPERIMENTAL NEUROLOGY

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Behavioral testing regimens in genetic-based animal models of Parkinson's disease: Cogencies and caveats

(2013) Alexander Bury et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pathogenesis-Targeted, Disease-Modifying Therapies in Parkinson Disease

(2013) Amaal AlDakheel et al.   Neurotherapeutics

When Mice Mislead

(2013) J. Couzin-Frankel   SCIENCE

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Translating Drugs From Animals to Humans: Do We Need to Prove Efficacy?

(2013) Gary D. Novack   Translational Vision Science & Technology

The Importance of Preclinical Trial Timing - a Potential Reason for the Disconnect between mouse Studies and Human Clinical Trials in ALS

(2012) Qiongman Kong et al.   CNS Neuroscience & Therapeutics

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies

(2012) Erwan Bezard et al.   MOVEMENT DISORDERS

Extrapolating from Animals to Humans

(2012) J. P. A. Ioannidis   Science Translational Medicine

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

Profiling changes in gait dynamics resulting from progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal lesioning

(2011) Natalie R.S. Goldberg et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

Dopaminergic and behavioral correlates of progressive lesioning of the nigrostriatal pathway with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

(2011) N.R.S. Goldberg et al.   NEUROSCIENCE

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale

(2010) Lisa M. Shulman et al.   ARCHIVES OF NEUROLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of the Journal of Cerebral Blood Flow and Metabolism

(2010) Hanna V Vesterinen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Establishing Efficacy of Human Products Using Animals

(2010) P. J. Snoy   VETERINARY PATHOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Of Mice and Men

(2009) Hugo Geerts   CNS DRUGS

Comparing two small samples with an unstable, treatment-independent baseline

(2009) Skirmantas Janušonis   JOURNAL OF NEUROSCIENCE METHODS

Clinical neuroprotection in Parkinson's disease — Still waiting for the breakthrough

(2009) Matthias Löhle et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Launching invasive, first-in-human trials against Parkinson's disease: Ethical considerations

(2009) Jonathan Kimmelman et al.   MOVEMENT DISORDERS

The MitoPark Mouse – An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons

(2009) Mats I. Ekstrand et al.   PARKINSONISM & RELATED DISORDERS

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Criteria for validating mouse models of psychiatric diseases

(2008) Kathryn K. Chadman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The Unified Dyskinesia Rating Scale: Presentation and clinimetric profile

(2008) Christopher G. Goetz et al.   MOVEMENT DISORDERS

Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol

(2008) Gloria E. Meredith et al.   PARKINSONISM & RELATED DISORDERS

Good Laboratory Practice

(2008) Malcolm R. Macleod et al.   STROKE