Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells

ROS-Induced CXCR4 Signaling Regulates Mantle Cell Lymphoma (MCL) Cell Survival and Drug Resistance in the Bone Marrow Microenvironment via Autophagy

(2015) Z. Chen et al.   CLINICAL CANCER RESEARCH

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells

(2013) Xudong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Taxifolin Enhances Andrographolide-Induced Mitotic Arrest and Apoptosis in Human Prostate Cancer Cells via Spindle Assembly Checkpoint Activation

(2013) Zhong Rong Zhang et al.   PLoS One

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation

(2013) A Notte et al.   Cell Death & Disease

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

(2012) Jing Zhou et al.   Autophagy

Network-based drug discovery by integrating systems biology and computational technologies

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Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells

(2012) Xian-ling Guo et al.   CANCER LETTERS

Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K

(2012) N. Oi et al.   Cancer Prevention Research

Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore

(2012) Wei Chen et al.   CARCINOGENESIS

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell type-dependent effects of andrographolide on human cancer cell lines

(2012) Myra T.W. Cheung et al.   LIFE SCIENCES

Autophagy Inhibitor Chloroquine Enhanced the Cell Death Inducing Effect of the Flavonoid Luteolin in Metastatic Squamous Cell Carcinoma Cells

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Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways

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Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Methods for detecting autophagy and determining autophagy-induced cell deathThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

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Mitochondrial-Mediated Apoptosis in Lymphoma Cells by the Diterpenoid Lactone Andrographolide, the Active Component of Andrographis paniculata

(2010) S. Yang et al.   CLINICAL CANCER RESEARCH

Induction of Reactive Oxygen Species-mediated Autophagy by a Novel Microtubule-modulating Agent

(2010) Prasanthi Karna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of JNK in the regulation of autophagic cell death

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Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis

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Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic L929 cell death

(2008) Yan Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis

(2008) S R Jada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells

(2008) Lu Yang et al.   CANCER LETTERS

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide

(2008) Ming-Der Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-tumor activities of andrographolide, a diterpene fromAndrographis paniculata, by inducing apoptosis and inhibiting VEGF level

(2008) Feng Zhao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury

(2008) A. Y. H. Woo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation

(2008) J. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin

(2008) M. D. Siegelin et al.   MOLECULAR CANCER THERAPEUTICS

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY