The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways

The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway

(2016) Amos C. Hung et al.   CANCER LETTERS

New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer

(2016) Sherry X. Yang et al.   CANCER TREATMENT REVIEWS

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B‐cell lymphoma

(2016) Katharina Engel et al.   EMBO Molecular Medicine

3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase

(2015) I-Hua Chen et al.   BIOCHIMIE

Nitrostyrene Derivatives Act as RXR  Ligands to Inhibit TNF  Activation of NF- B

(2015) Z. Zeng et al.   CANCER RESEARCH

PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition

(2015) Nandini Verma et al.   Nature Communications

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

(2015) Emma J. Davies et al.   Scientific Reports

NCI’s provocative questions on cancer: some answers to ignite discussion

(2015) Mikhail V. Blagosklonny   Oncotarget

Targeting Autophagy Addiction in Cancer

(2015) Joseph D. Mancias et al.   Oncotarget

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

(2015) Arnaldur Hall et al.   Oncotarget

High Id1 expression, a generally negative prognostic factor, paradoxically predicts a favorable prognosis for adjuvant paclitaxel plus cisplatin therapy in surgically treated lung cancer patients

(2015) Yu-Jen Cheng et al.   Oncotarget

Cross talk Initiated by Endothelial Cells Enhances Migration and Inhibits Anoikis of Squamous Cell Carcinoma Cells through STAT3/Akt/ERK Signaling

(2015) Kathleen G. Neiva et al.   NEOPLASIA

Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: An emerging treatment strategy for squamous cell lung carcinoma

(2014) Joseph Thaddeus Beck et al.   CANCER TREATMENT REVIEWS

Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents

(2014) Samira Rahmani-Nezhad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer

(2014) Frances E. Lennon et al.   PLoS One

Establishment of a Non-Invasive Semi-Quantitative Bioluminescent Imaging Method for Monitoring of an Orthotopic Esophageal Cancer Mouse Model

(2014) Shinji Kuroda et al.   PLoS One

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

(2013) Y. Takahashi et al.   BLOOD

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling

(2013) Yun-Ju Chen et al.   GYNECOLOGIC ONCOLOGY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

Addiction to c-MYC in multiple myeloma

(2012) T. Holien et al.   BLOOD

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Autophagy inhibited Ehrlich ascitic tumor cells apoptosis induced by the nitrostyrene derivative compounds: Relationship with cytosolic calcium mobilization

(2011) Andrana K. Calgarotto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis

(2011) Katrin M Sjoquist et al.   LANCET ONCOLOGY

The synthesis and biologic evaluation of anti-platelet and cytotoxic β-nitrostyrenes

(2010) Pei-Wen Hsieh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents

(2010) Yvonne M. McNamara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Esophagogastric cancer: Targeted agents

(2010) Geoffrey Y. Ku et al.   CANCER TREATMENT REVIEWS

E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory β-E-nitrostyrenes

(2009) Robin K. Pettit et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epithelial-mesenchymal transition in cancer development and its clinical significance

(2009) Masaaki Iwatsuki et al.   CANCER SCIENCE

Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway

(2009) Todd Morgan et al.   CURRENT CANCER DRUG TARGETS

Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway

(2009) Bin Li et al.   INTERNATIONAL JOURNAL OF CANCER

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Shifting paradigms: the seeds of oncogene addiction

(2009) Charles L Sawyers   NATURE MEDICINE

Pharmacokinetics and pharmacogenomics in esophageal cancer chemoradiotherapy

(2008) Toshiyuki Sakaeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Transient Potent BCR-ABL Inhibition Is Sufficient to Commit Chronic Myeloid Leukemia Cells Irreversibly to Apoptosis

(2008) Neil P. Shah et al.   CANCER CELL

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH