Article
Hematology
Ming-Yue Fei, Yong Wang, Bin-He Chang, Kai Xue, Fangyi Dong, Dan Huang, Xi-Ya Li, Zi-Juan Li, Cheng-Long Hu, Ping Liu, Ji-Chuan Wu, Peng-Cheng Yu, Ming-Hua Hong, Shu-Bei Chen, Chun-Hui Xu, Bing-Yi Chen, Yi-Lun Jiang, Na Liu, Chong Zhao, Jia-Cheng Jin, Dan Hou, Xin-Chi Chen, Yi-Yi Ren, Chu-Han Deng, Jia-Ying Zhang, Li-juan Zong, Rou-Jia Wang, Fei-Fei Gao, Hui Liu, Qun-Ling Zhang, Ling-Yun Wu, Jinsong Yan, Shuhong Shen, Chun-Kang Chang, Xiao-Jian Sun, Lan Wang
Summary: The high expression of ID1 in the bone marrow microenvironment of AML patients, induced by BMP6 secreted from AML cells, regulates the proliferation of AML cells. Knocking out ID1 in mesenchymal cells can suppress AML cell proliferation and delay AML progression, while the interaction between ID1 and RNF4 can regulate SP1 protein levels, affecting AML cell proliferation.
Article
Immunology
Yu Xia, Katalin Sandor, Joy A. Pai, Bence Daniel, Saravanan Raju, Renee Wu, Sunnie Hsiung, Yanyan Qi, Tenzin Yangdon, Mariko Okamoto, Chun Chou, Kamir J. Hiam-Galvez, Robert D. Schreiber, Kenneth M. Murphy, Ansuman T. Satpathy, Takeshi Egawa
Summary: The study reveals the heterogeneity and plasticity of CD4(+) T cells during chronic infection and tumor response, and highlights their population dynamics through a stable, bipotent intermediate state.
Article
Biology
Judith Pineau, Lea Pinon, Olivier Mesdjian, Jacques Fattaccioli, Ana-Maria Lennon Dumenil, Paolo Pierobon
Summary: Immune synapse formation is a crucial step for lymphocyte activation. The roles of actin and microtubule cytoskeletons in synapse formation are well-known, but the coordination of different events involved in synapse formation by actin-microtubule interactions remains unclear. By using a microfluidic pairing device, the study provides unprecedented resolution in understanding the dynamics of synapse formation in B cells. The results reveal the dominance of actin and microtubule dynamics in local and global events, respectively, and also highlight the unexpected role of microtubules and the GEF-H1-RhoA axis in controlling F-actin polymerization for the formation and maintenance of a functional immune synapse.
Article
Medicine, General & Internal
Xingyi Kuang, Jie Xiong, Tingting Lu, Weili Wang, Zhaoyuan Zhang, Jishi Wang
Summary: Deubiquitylating enzyme USP1 is overexpressed in B-ALL patients, promoting disease progression through the ID1/AKT signaling pathway. Inhibiting USP1 suppresses cell proliferation and induces apoptosis, suggesting promising therapeutic potential.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Immunology
Boyoung Shin, Wen Zhou, Jue Wang, Fan Gao, Ellen V. Rothenberg
Summary: Runx factors regulate lineage specification of hematopoietic cells, including T lymphocytes, by binding to specific genomic regions. In early T cell development, dynamic Runx binding shifts are regulated by Runx dosage and functional partners rather than local chromatin state. Limited Runx protein availability leads to premature Runx occupancy at post-commitment binding sites, accelerating T cell lineage development. This regulation involves the activation of T cell-identity and innate lymphoid cell programs by Runx and other transcription factors. Overall, Runx proteins play a crucial role in directing lineage-fate decisions in various cell types.
Article
Immunology
Juan Yin, Tong Hu, Lijuan Xu, Liping Zhang, Jianyun Zhu, Yulan Ye, Zhi Pang
Summary: Research indicates that hsa_circRNA_103124 is upregulated in Crohn's disease (CD) and promotes macrophage M1 polarization through activation of the TLR4/NF-κB pathway, maintaining an inflammatory microenvironment. Hsa_circRNA_103124 could serve as a potential biomarker and therapeutic target in the progression of CD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun Fan, Shirley Wang, Kai Chen, Zhongjie Sun
Summary: This study found that aging and arterial stiffness can be caused by Klotho deficiency leading to immune dysfunction and decreased arterial elasticity. AAV-SKL can alleviate arterial stiffness in aging mice by restoring B-cell populations and serum IgG levels.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Guo-Qing Li, Xiao-Mei Liu, Bing-Li Liu, Yi Zhong, Qing-Wei Gu, Jing-Jing Miao, Jie Wang, Shu Liu, Xiao-Ming Mao
Summary: Activated B cells contribute to the development and progression of hyperthyroid heart disease. High concentrations of triiodothyronine (T3) can induce the overexpression of B-cell activating factor (BAFF) in myocardial cells, leading to B-cell activation, increased inflammatory response, and ventricular remodeling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Bin Liu, Shuo Zhao, Pengli Li, Yilu Yin, Qingliang Niu, Jinqiang Yan, Danfeng Huang
Summary: In response to environmental stresses, plants induce alternative splicing to generate multiple transcripts, allowing for fine-tuning of gibberellin levels. The study identified a novel transcript of the gibberellin-deactivating enzyme CsGA2ox8 and demonstrated that different isoforms play distinct roles in deactivating bioactive GAs. Expression analysis showed that under different light intensities, the transcripts of CsGA2ox8 were upregulated at varying rates, suggesting a regulatory mechanism through alternative splicing in plants.
HORTICULTURE RESEARCH
(2021)
Article
Medical Laboratory Technology
Shu Liu, Jing-Jing Miao, Xiao Zhou, Qi Sun, Xiao-Ming Mao
Summary: This study suggests that elevated thyroid hormone levels are associated with the pathological progression of Graves' disease. High levels of triiodothyronine can induce the differentiation of autoreactive B cells, and BAFF may be a potential target for the treatment of Graves' hyperthyroidism recurrence.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Food Science & Technology
Hui Gao, Chunping Rao, Ruijuan Song, Shufen Han
Summary: The study demonstrated that oat fiber feeding can hinder the progression of atherosclerosis by affecting circulating oxysterols, alleviating hepatic inflammatory response, and targeting the TLR4/MyD88/NF-kB signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Hyunyoung Yoon, Hye-Kyoung Lee, Kyung Lib Jang
Summary: This study demonstrates that H2O2 inhibits HBV replication in human hepatoma cell lines, and this inhibition is dependent on the presence of p53. H2O2 is unable to inhibit HBV replication in a mutant without HBx, but complementation with HBx restores the inhibitory effect. The mechanism of inhibition involves upregulation of p53 and subsequent degradation of HBx by the E3 ligase Siah-1. This study provides insights into the regulation of HBV replication under oxidative stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Peng Ding, Qiyuan Tan, Zhanying Wei, Qiyu Chen, Chun Wang, Luyue Qi, Li Wen, Changqing Zhang, Chen Yao
Summary: The study revealed that TLR9(-/-) mice exhibit low bone mass and chronic inflammation with increased levels of inflammatory cytokines, leading to enhanced osteoclastogenesis and bone loss. TLR9 deletion altered the gut microbiota, causing systemic inflammation and bone loss.
Article
Plant Sciences
Jaewoong Jang, Hyunji Lee, Jaewon Song, Taehyun Bae, Minwoo Park, Young V. Kwon, Doheon Lee, Yoosik Yoon
Summary: The ethanol extract of Radix Paeoniae (RP) was found to restore skeletal muscle function and mass in cisplatin-treated mice by downregulating muscle-specific ubiquitin E3 ligases, NF-kappa B signaling, and cytokine levels, resulting in the restoration of key proteins involved in muscle contraction and differentiation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Cesar J. Carranza-Aguilar, Araceli Hernandez-Mendoza, Carlos Mejias-Aponte, Kenner C. Rice, Marisela Morales, Claudia Gonzalez-Espinosa, Silvia L. Cruz
Summary: Morphine and fentanyl have differential effects on the activation of NLRP3 inflammasome in glial and neuronal cells in the dorsal raphe nucleus (DRN), suggesting the involvement of neuroinflammation in opioid-induced analgesia and fentanyl-induced hyperalgesia.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Oncology
Friederike Bachmann, Martin Schreder, Monika Engelhardt, Christian Langer, Denise Wolleschak, Lars Olof Muegge, Heinz Duerk, Kerstin Schaefer-Eckart, Igor Wolfgang Blau, Martin Gramatzki, Peter Liebisch, Matthias Grube, Ivana Metzler, Florian Bassermann, Bernd Metzner, Christoph Roellig, Bernd Hertenstein, Cyrus Khandanpour, Tobias Dechow, Holger Hebart, Wolfram Jung, Sebastian Theurich, Georg Maschmeyer, Hans Salwender, Georg Hess, Max Bittrich, Leo Rasche, Annamaria Brioli, Kai-Uwe Eckardt, Christian Straka, Swantje Held, Hermann Einsele, Stefan Knop
Summary: Renal insufficiency is common in newly diagnosed multiple myeloma, and it can be caused by the disease itself, medical interventions, or infections. Quick disease control with effective therapy can help improve renal function. Different three-drug regimens for initial myeloma treatment had a positive impact on kidney function, but some patients may experience worsening renal function following induction therapy.
Article
Hematology
Helal Mohammed Mohammed Ahmed, Subbaiah Chary Nimmagadda, Yahya S. Al-Matary, Maren Fiori, Tobias May, Daria Frank, Pradeep Kumar Patnana, Christian Recher, Christoph Schliemann, Jan-Henrik Mikesch, Thorsten Koenig, Frank Rosenbauer, Wolfgang Hartmann, Jan Tuckermann, Ulrich Duhrsen, Wei Lanying, Martin Dugas, Bertram Opalka, Georg Lenz, Cyrus Khandanpour
Summary: This study showed functional differences between AML MSCs and HD MSCs, with Notch signaling in AML MSCs enhancing AML cell proliferation, while dexamethasone or Notch inhibitors could disrupt the interaction between AML cells and AML MSCs, improving treatment outcomes in AML patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqing Xie, Daria Frank, Pradeep Kumar Patnana, Judith Schuette, Yahya Al-Matary, Longlong Liu, Lanying Wei, Martin Dugas, Julian Varghese, Subbaiah Chary Nimmagadda, Cyrus Khandanpour
Summary: The study identified a therapeutic role for curcumin treatment in delaying the expansion of GFI1-36N or -KD, NUP98-HODXD13 leukemic cells and prolonging AML-free survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maria V. Yusenko, Abhiruchi Biyanee, Daria Frank, Leonhard H. F. Koehler, Mattias K. Andersson, Cyrus Khandanpour, Rainer Schobert, Goeran Stenman, Bernhard Biersack, Karl-Heinz Klempnauer
Summary: This study introduces a novel MYB inhibitory compound called Bcr-TMP, which shows potential therapeutic effects on leukemias and cancers dependent on deregulated MYB activity. Bcr-TMP down-regulates MYB target genes, induces cell death and differentiation, and exhibits stronger anti-proliferative effects on MYB-addicted primary cells. Additionally, Bcr-TMP acts through p300 and has anti-microtubule activity. Further research is needed to understand its mechanism of action and therapeutic potential.
Article
Oncology
Daniela V. Wenge, Klaus Wethmar, Corinna A. Klar, Hedwig Kolve, Tim Sauer, Linus Angenendt, Georg Evers, Simon Call, Andrea Kerkhoff, Cyrus Khandanpour, Torsten Kessler, Rolf Mesters, Christoph Schliemann, Jan-Henrik Mikesch, Christian Reicherts, Monika Brueggemann, Wolfgang E. Berdel, Georg Lenz, Matthias Stelljes
Summary: This retrospective study evaluated the treatment outcomes of 93 elderly patients with acute lymphoblastic leukemia who received intensive chemotherapy. The study identified age and performance status as risk factors for poor outcomes, while intensity of treatment and disease characteristics did not significantly affect overall survival. The results suggest that intensive treatment of elderly ALL patients is feasible but associated with significant toxicity.
Article
Oncology
Longlong Liu, Pradeep Kumar Patnana, Xiaoqing Xie, Daria Frank, Subbaiah Chary Nimmagadda, Annegret Rosemann, Marie Liebmann, Luisa Klotz, Bertram Opalka, Cyrus Khandanpour
Summary: This study demonstrates that AML cells with an MLL/AF9 genotype have a high dependency on oxidative phosphorylation and could be targeted for therapy using metformin.
Article
Oncology
Hira Mian, Christine Eisfeld, Christopher P. Venner, Esther Masih-Khan, Moustafa Kardjadj, Victor H. Jimenez-Zepeda, Cyrus Khandanpour, Georg Lenz, Arleigh McCurdy, Michael Sebag, Kevin Song, Richard LeBlanc, Darrell White, Julie Stakiw, Anthony Reiman, Martha Louzada, Muhammad Aslam, Rami Kotb, Engin Gul, Donna Reece
Summary: Daratumumab-containing therapies are effective regimens in patients progressing on lenalidomide maintenance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Daria Frank, Ramkumar Moorthy, John C. Widen, Cyrus Khandanpour, Daniel A. Harki, Karl-Heinz Klempnauer, Luca Abdel Ghani, Maria V. Yusenko, Wolfgang Doerner
Summary: C/EBP β is a transcription factor that cooperates with MYB to maintain proliferation and differentiation block of AML cells. A synthetic analog of helenalin inhibits C/EBP β by covalently binding to cysteine residues in the transactivation domain, leading to enhanced differentiation, cell death, and reduced self-renewal potential of AML cells. Gene expression profiling confirms the relevance of C/EBP β as a therapeutic target. However, further development is needed to improve the effectiveness of the synthetic analog as a C/EBP β inhibitor.
Article
Oncology
Longlong Liu, Pradeep Kumar Patnana, Xiaoqing Xie, Daria Frank, Subbaiah Chary Nimmagadda, Minhua Su, Donghua Zhang, Thorsten Koenig, Frank Rosenbauer, Marie Liebmann, Luisa Klotz, Wendan Xu, Jan Vorwerk, Felix Neumann, Jana Huve, Andreas Unger, Jurgen Gunther Okun, Bertram Opalka, Cyrus Khandanpour
Summary: Recent studies have revealed the important role of transcription factor GFI1B in metabolic regulation during hematopoiesis and leukemia development. Gfi1b deletion leads to activation of mitochondrial respiration and alteration of energy metabolism towards oxidative phosphorylation (OXPHOS). Gfi1b also epigenetically regulates multiple genes involved in fatty acid oxidation (FAO). The correlation between Gfi1b expression level and metabolic phenotype is influenced by genetic variations in AML cells. Inhibition of FAO or OXPHOS significantly hinders leukemia progression, and Gfi1b-deficient AML cells are more sensitive to drugs targeting OXPHOS and FAO, suggesting new potential therapeutic strategies.
Article
Oncology
Evgenii Shumilov, Lena Aperdannier, Nicole Schmidt, Christoph Szuszies, Albrecht Neesse, Petra Hoffknecht, Cyrus Khandanpour, Jan-Henrik Mikesch, Matthias Stelljes, Goeran Ramin Boeckel, Phil-Robin Tepasse, Lea Reitnauer, Raphael Koch, Justin Hasenkamp, Ulrike Bacher, Simone Scheithauer, Lorenz Truemper, Norbert Schmitz, Gerald Wulf, Andrea Kerkhoff
Summary: This study investigated the impact of COVID-19 vaccines on SARS-CoV-2 infections and the course of COVID-19 in cancer patients. The results showed that vaccinated cancer patients had a milder course of COVID-19 and reduced hospitalization time and mortality compared to non-vaccinated patients. These findings provide evidence for the significant benefits of COVID-19 vaccines for cancer patients.
Article
Oncology
Luca Heinemann, Klara Maria Moellers, Helal Mohammed Mohammed Ahmed, Lanying Wei, Kaiyan Sun, Subbaiah Chary Nimmagadda, Daria Frank, Anja Baumann, Alexandra M. Poos, Martin Dugas, Julian Varghese, Marc-Steffen Raab, Cyrus Khandanpour
Summary: This study investigated the gene differences between MSCs from multiple myeloma patients and those from other diseases, showing an enrichment of the PI3K-AKT-mTOR signaling pathway in MM-associated MSCs and the inhibitory effect of Pictilisib on these cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nicole Baeumer, Annika Scheller, Lisa Wittmann, Andreas Faust, Mara Apel, Subbaiah Chary Nimmagadda, Christiane Geyer, Katharina Grunert, Neele Kellmann, Matthias Peipp, Sareetha Kailayangiri, Matias Ezequiel Gutierrez Suburu, Cristian A. Strassert, Mathias Schenk, Lilo Greune, Christian Rueter, Petra Dersch, Wolfgang Hartmann, Claudia Rossig, Dario Neri, Carsten Mueller-Tidow, Christian Schwoeppe, Christoph Schliemann, Cyrus Khandanpour, Georg Lenz, Wolfgang E. Berdel, Sebastian Baeumer
Summary: This study developed a new experimental platform technology for targeting molecular oncogenes in AML using electrostatic nanocarriers. It showed therapeutic activity against AML in cell lines and animal models, specifically targeting mutated genes.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Carolin Krekeler, Lea Reitnauer, Ulrike Bacher, Cyrus Khandanpour, Leander Steger, Goran Ramin Boeckel, Justine Klosner, Phil-Robin Tepasse, Marcel Kemper, Marc Tim Hennies, Rolf Mesters, Matthias Stelljes, Norbert Schmitz, Andrea Kerkhoff, Christoph Schliemann, Jan-Henrik Mikesch, Nicole Schmidt, Georg Lenz, Annalen Bleckmann, Evgenii Shumilov
Summary: This study provides data on the efficacy of COVID-19 prime-boost vaccines in patients with hematologic malignancies and offers guidance for managing weak or failed responses to the vaccines. The study found that 55% of the patients achieved seroconversion after vaccination. Factors such as age, lymphocytopenia, ongoing treatment, and anti-CD20 B-cell depletion were predictors of booster failure. Passive immunization was associated with a lower risk of breakthrough infections.
Article
Oncology
Michael Oertel, Tom Schlusemann, Evgenii Shumilov, Gabriele Reinartz, Anne Bremer, Stephan Rehn, Georg Lenz, Cyrus Khandanpour, Hans Theodor Eich
Summary: This study evaluated the tolerability of concurrent radiotherapy and targeted therapy. The results showed that radiotherapy is safe and feasible in the treatment of multiple myeloma, but careful monitoring of potential toxicities is necessary.
Article
Oncology
Lisa B. Leypoldt, Maria Gavriatopoulou, Britta Besemer, Hans Salwender, Marc S. Raab, Axel Nogai, Cyrus Khandanpour, Volker Runde, Anna Jauch, Manola Zago, Peter Martus, Hartmut Goldschmidt, Carsten Bokemeyer, Meletios A. Dimopoulos, Katja C. Weisel
Summary: This study evaluated the safety and efficacy of daratumumab, bortezomib, and dexamethasone in multiple myeloma patients with severe renal function impairment. The treatment showed an overall response rate of 67% and improved renal function in patients. This study suggests that this treatment regimen could be considered in the clinical practice for multiple myeloma patients with severe renal function impairment.