Article
Biochemistry & Molecular Biology
Alexe Grenier, Jean Legault, Andre Pichette, Lorry Jean, Audrey Belanger, Roxane Pouliot
Summary: The study evaluated the safety and anti-aging efficacy of a Kalmia angustifolia extract using reconstructed skin substitutes, demonstrating strong antioxidant and anti-inflammatory activities. The extract increased dermal thickness and enhanced elastin and collagen-1 expression, suggesting promising antioxidant efficacy and anti-aging potential.
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Biotechnology & Applied Microbiology
Katarzyna Michalak-Micka, Dominic Rutsche, Luca Mazzone, Vanessa L. Buchler, Ueli Moehrlen, Agnes S. Klar, Thomas Biedermann
Summary: This study provides an in-depth analysis of Merkel cells in human fetal skin. It confirms the phenotypical features of these cells and demonstrates their persistence after isolation, in culture, and in skin substitutes. The findings are important for the future application of fetal tissue-engineered skin in clinical settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bingbing Xu, Jing Ye, Bao-Shi Fan, Xinjie Wang, Ji-Ying Zhang, Shitang Song, Yifan Song, Wen-Bo Jiang, Xing Wang, Jia-Kuo Yu
Summary: This study successfully prepared a versatile meniscus composite scaffold with heterogeneous bionic structures through the regulation of microenvironment, combining various techniques.
BIOACTIVE MATERIALS
(2023)
Review
Oncology
Mickael Ohanna, Pierric Biber, Marcel Deckert
Summary: ——Metastatic melanoma is a aggressive skin tumor with poor prognosis, and current treatments have limited efficacy. This review discusses the role of ubiquitination in melanoma development and resistance to therapy and highlights the potential of deubiquitination enzymes as novel therapeutic targets.
Article
Chemistry, Physical
Cancan Zhao, Jianyu Wan, Liangzhu Zhang, Chen Zhang, Jiemin Wang, Kaili Lin, Xudong Wang
Summary: In recent years, visible-to-near-infrared (NIR) light has been developed for melanoma therapy and tissue regeneration. Researchers have discovered that a hydrogel called HA@BCN, fabricated under blue light activation, can achieve gentle and powerful melanoma therapy and wound healing under NIR light irradiation. The hydrogel can be triggered by NIR light to achieve at least an 80% mortality rate in tumor cells within 10 minutes, and it can also accelerate wound healing.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ying Xiong, Yiyu Zhang, Zefan Li, Md Shamim Reza, Xinyu Li, Xiaodong Tian, Hui-wang Ai
Summary: The NanoLuc luciferase and its furimazine substrate have greatly improved bioluminescence assays and imaging. However, their use for mammalian tissue imaging is limited by the low tissue penetration of blue photons. In this study, a mutant NLuc called QLuc was developed, which catalyzes the oxidation of a synthetic QTZ luciferin to produce bright and red-shifted emission. This red-shifted luciferase showed improved performance for imaging deep-tissue targets in live mice. Using QLuc, the researchers also demonstrated the use of immunoBLI for molecular imaging of tumor-associated antigens in a xenograft mouse model. QLuc is expected to have broad applications in noninvasive mammalian imaging, and immunoBLI serves as a convenient and nonradioactive molecular imaging tool for animal models in basic and preclinical research.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Yaling Zheng, Wei Wang, Yao Gao, Weiyi Wang, Renwu Zhang, Dejun Wu, Luodan Yu, Yu Chen
Summary: An injectable CuO2 nanodots-engineered thermosensitive chitosan hydrogel (CuO2-BSO@Gel) was developed for enhanced melanoma chemo-sonodynamic therapy and improved infected wound healing. This multifunctional hydrogel featured enhanced chemodynamic therapy (CDT) and sonodynamic therapy (SDT) by using CuO2 nanodots as efficient sonosensitizers and self-supplying H2O2. The synergistic effect of SDT and CDT was further amplified by loaded BSO, resulting in specific ferroptosis and improved wound healing with enhanced angiogenesis.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Mengying Hou, Yuansong Wei, Ziyin Zhao, Wenqing Han, Renxiang Zhou, Yang Zhou, Yiran Zheng, Lichen Yin
Summary: In this study, cell-membrane-based nanodecoys were developed to treat autoimmune diseases by interrupting the self-promoted inflammatory cascade. These nanodecoys showed high accumulation levels and scavenging efficiency, inhibiting T cell activation and restoring immune tolerance, thus alleviating autoimmune damages.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh M. Linville, Utpal Pal, J. Stephen Dumler, Peter C. Searson
Summary: This study investigated the dissemination mechanism of Borrelia burgdorferi using a tissue-engineered human dermal microvessel model. The results showed that collagen fibers acted as inert obstacles to the migration of B. burgdorferi, and intravasation occurred at cell-cell junctions. The study also found that B. burgdorferi alone could induce endothelium activation. These findings provide new insights into the dissemination of B. burgdorferi and the use of tissue-engineered models in studying vector-borne pathogens.
Article
Pharmacology & Pharmacy
Anna Nowak, Martyna Zagorska-Dziok, Magdalena Peruzynska, Krystyna Cybulska, Edyta Kucharska, Paula Ossowicz-Rupniewska, Katarzyna Piotrowska, Wiktoria Duchnik, Lukasz Kucharski, Tadeusz Sulikowski, Marek Drozdzik, Adam Klimowicz
Summary: This study evaluated the biological activity of Epilobium angustifolium extracts in the treatment of skin diseases. The extracts showed antioxidant, antibacterial, anti-inflammatory, and anti-aging properties, as well as the ability to promote wound healing and penetrate the skin. Therefore, E. angustifolium extracts may be an interesting alternative for dermatological and cosmetic preparations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emilie J. Doucet, Sergio Cortez Ghio, Martin A. Barbier, Etienne Savard, Brice Magne, Meryem Safoine, Danielle Larouche, Julie Fradette, Lucie Germain
Summary: Tissue-engineered skin substitutes (TESs) used for severe burn injuries have traditionally been cultured using bovine serum, but a new study shows that serum-free media can be used to produce high quality TESs that are macroscopically and histologically similar to those produced with serum. The serum-free TESs expressed the same genes and had comparable mechanical properties to serum-cultured TESs. They were also successfully grafted onto mice for a six-month period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Roisin Lynch, Ed C. Lavelle
Summary: Biocompatible and biodegradable biomaterials are widely used in regenerative medicine. Inflammation, though initially essential for wound healing, can have negative effects if prolonged. Therefore, careful consideration should be given to the choice of biomaterials to minimize inflammation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shichao Wan, Yannan Liu, Jingjing Shi, Daidi Fan, Binglin Li
Summary: The study found that ginsenoside Rk3, as an active component, can protect skin health by inhibiting photoaging and inflammation. Through experiments in which it was mixed with cream and applied to the skin of mice, the G-Rk3 cream was found to make the skin smooth and plump, and to slow or halt the changes in various biomarker levels associated with skin aging and inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefano Piazza, Giulia Martinelli, Urska Vrhovsek, Domenico Masuero, Marco Fumagalli, Andrea Magnavacca, Carola Pozzoli, Luisa Canilli, Massimo Terno, Marco Angarano, Mario Dell'Agli, Enrico Sangiovanni
Summary: Cutibacterium acnes (C. acnes) is one of the main triggers of acne vulgaris, and this study investigated the effect of a extract from Hamamelis virginiana bark on C. acnes-induced inflammation in human keratinocytes. The extract showed anti-inflammatory activity and partially impaired NF-kappa B activation, but had no antibacterial or antibiofilm activities. Further investigations are needed to explore the potential of this extract in other inflammatory-based skin diseases.