Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer

Oligomeric TTR V30M aggregates compromise cell viability, erythropoietin gene expression and promoter activity in the human hepatoma cell line Hep3B

(2015) Luciana Moreira et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Amyloidogenic and non-amyloidogenic transthyretin variants interact differently with human cardiomyocytes: insights into early events of non-fibrillar tissue damage

(2015) Pallavi Manral et al.   BIOSCIENCE REPORTS

CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci

(2015) Yanshuang Mu et al.   FEBS LETTERS

Tetrabromobisphenol A (TBBPA): Possible modes of action of toxicity and carcinogenicity in rodents

(2015) David Y. Lai et al.   FOOD AND CHEMICAL TOXICOLOGY

Cardiac amyloidosis: where are we today?

(2015) K. S. Patel et al.   JOURNAL OF INTERNAL MEDICINE

Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma

(2015) Irina Iakovleva et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Diversity of Mechanisms Influenced by Transthyretin in Neurobiology: Development, Disease and Endocrine Disruption

(2015) B. Alshehri et al.   JOURNAL OF NEUROENDOCRINOLOGY

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

(2015) Morie A. Gertz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Liver transplantation in transthyretin amyloidosis: Issues and challenges

(2015) Andreia Carvalho et al.   LIVER TRANSPLANTATION

A reproductive, developmental and neurobehavioral study following oral exposure of tetrabromobisphenol A on Sprague-Dawley rats

(2015) Rhian B. Cope et al.   TOXICOLOGY

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Flavonoid Luteolin, but Not Luteolin-7-O-Glucoside, Prevents a Transthyretin Mediated Toxic Response

(2015) Irina Iakovleva et al.   PLoS One

Amyloid Cardiomyopathy in Hereditary Transthyretin V30M Amyloidosis - Impact of Sex and Amyloid Fibril Composition

(2015) Sandra Arvidsson et al.   PLoS One

Degradation and Metabolism of Tetrabromobisphenol A (TBBPA) in Submerged Soil and Soil–Plant Systems

(2014) Feifei Sun et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease

(2014) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin

(2014) Takeshi Yokoyama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis

(2014) Akihiro Yanagisawa et al.   MODERN PATHOLOGY

Environmental Chemical Exposure May Contribute to Uterine Cancer Development

(2014) J. K. Dunnick et al.   TOXICOLOGIC PATHOLOGY

Tuning Transthyretin Amyloidosis Inhibition Properties of Iododiflunisal by Combinatorial Engineering of the Nonsalicylic Ring Substitutions

(2014) Maria Vilaró et al.   ACS Combinatorial Science

Transthyretin Is Dysregulated in Preeclampsia, and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model

(2013) Satyan S. Kalkunte et al.   AMERICAN JOURNAL OF PATHOLOGY

Polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD) and “novel” brominated flame retardants in house dust in Germany

(2013) H. Fromme et al.   ENVIRONMENT INTERNATIONAL

Inhibition of Human Transthyretin Aggregation by Non-Steroidal Anti-Inflammatory Compounds: A Structural and Thermodynamic Analysis

(2013) Ricardo Sant'Anna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of the Fibrillogenesis Inhibition Properties of Two Transthyretin Ligands by Halogenation

(2013) Ellen Y. Cotrina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

(2013) Teresa Coelho et al.   JOURNAL OF NEUROLOGY

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

(2013) S. C. Penchala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural polyphenols as modulators of TTR amyloidogenesis:in vitroandin vivoevidences towards therapy

(2012) Nelson Ferreira et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition

(2012) Nelson Ferreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transthyretin (TTR) Cardiac Amyloidosis

(2012) Frederick L. Ruberg et al.   CIRCULATION

Transthyretin Deposition in Familial Amyloidotic Polyneuropathy

(2012) M. J. Saraiva et al.   CURRENT MEDICINAL CHEMISTRY

Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis

(2012) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders with and without Dementia

(2012) Walter Maetzler et al.   PLoS One

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

(2011) M. M. Alhamadsheh et al.   Science Translational Medicine

Differences in neonatal neurotoxicity of brominated flame retardants, PBDE 99 and TBBPA, in mice

(2011) Henrik Viberg et al.   TOXICOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biodegradation kinetics of selected brominated flame retardants in aerobic and anaerobic soil

(2010) Jenny Rattfelt Nyholm et al.   ENVIRONMENTAL POLLUTION

The binding of synthetic triiodo l-thyronine analogs to human transthyretin: Molecular basis of cooperative and non-cooperative ligand recognition

(2010) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

(2009) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nephrotoxic Potential and Toxicokinetics of Tetrabromobisphenol a in Rat for Risk Assessment

(2009) Mi Jeong Kang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

(2009) Teresa Mairal et al.   PLoS One

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

(2009) Satheesh K. Palaninathan et al.   PLoS One

Brominated flame retardants in the Arctic environment — trends and new candidates

(2009) Cynthia A. de Wit et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form

(2008) M. Lindhagen-Persson et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Prefibrillar transthyretin oligomers and cold stored native tetrameric transthyretin are cytotoxic in cell culture

(2008) Karin Sörgjerd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iodination of salicylic acid improves its binding to transthyretin

(2007) Luís Gales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS