Article
Chemistry, Applied
Victor Hugo Sousa Araujo, Mauricio Palmeira Chaves de Souza, Gabriela Correa Carvalho, Jonatas Lobato Duarte, Marlus Chorilli
Summary: The review discusses the use of chitosan in developing mucoadhesive systems for the treatment of local vaginal infections. Studies have shown that chitosan as a component of DDS is a promising device for treating vaginal infectious diseases.
CARBOHYDRATE POLYMERS
(2021)
Review
Immunology
Wenhui Qi, Huanrong Li, Chen Wang, Huiyang Li, Bingbing Zhang, Mengting Dong, Aiping Fan, Cha Han, Fengxia Xue
Summary: Mixed vaginitis, the presence of at least two types of vaginitis simultaneously, leads to abnormal vaginal environment and symptoms, although associations between symptoms and specific types are not well understood. The formation of mixed biofilms is common in mixed vaginitis, and studying polymicrobial interactions and mixed biofilms may provide new insights into the condition. Effective management and laboratory diagnosis are crucial to prevent inappropriate therapy and recurrence of mixed vaginitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Giuseppina Campisciano, Nunzia Zanotta, Vincenzo Petix, Manuela Giangreco, Giuseppe Ricci, Gianpaolo Maso, Manola Comar, Francesco De Seta
Summary: The translation discusses the diagnosis of bacterial vaginosis using Nugent score and qPCR, with qPCR proving to be more informative and accurate. Results showed discordance between Gram staining and qPCR in cases of partial BV, with a significant association between STIs and partial BV.
Article
Immunology
Bingbing Xiao, A. Disi, Hanyu Qin, Lan Mi, Dai Zhang
Summary: Mixed vaginitis is a condition where different types of vaginal pathogens coexist. Bacterial vaginosis (BV) plus vulvovaginal candidiasis (VVC) is the most common form. There is limited research on the clinical manifestations, pathogenesis, diagnostic criteria, and therapy of mixed vaginitis. This study investigated the effect of combined drug treatment on the vaginal microbiome in BV+VVC mixed vaginitis patients and found that it can alter the composition of the microbiome, with increased abundance of Lactobacillus improving the prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Caroline M. Mitchell, Sujatha Srinivasan, Nanxun Ma, Susan D. Reed, Michael C. Wu, Noah G. Hoffman, Daniel J. Valint, Sean Proll, Tina L. Fiedler, Kathy J. Agnew, Katherine A. Guthrie, David N. Fredricks
Summary: The Nugent score, a reference standard for diagnosing bacterial vaginosis (BV), has different correlations with relative abundances of vaginal microbiota in premenopausal and postmenopausal women. High Nugent scores should not be used to infer BV in postmenopausal women.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Michelle Bignoumba, Kelly H. Mbombe Moghoa, Jean Ulrich Muandze-Nzambe, Roland Fabrice Kassa Kassa, Yann Mouanga Ndzime, Amahani Gafou, Neil Michel Longo Pendy, Richard Onanga, Brice Serge Kumulungui
Summary: This study investigated the etiologies of vaginal infections among outpatients in south-eastern Gabon, finding that bacterial vaginosis (BV) and aerobic vaginitis (AV) were the most common types of infections, followed by vulvovaginal candidiasis (VVC). Trichomoniasis (TV) had a low incidence. Mixed infections were common among participants.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Review
Microbiology
Eric Armstrong, Rupert Kaul
Summary: HIV incidence remains high in Eastern and Southern Africa, particularly affecting women. The prevalence of bacterial vaginosis in African, Caribbean, and other Black (ACB) women is associated with increased risk of HIV acquisition, with Lactobacillus species such as L. crispatus offering better protection compared to the more common species L. iners. Further research is needed to determine the mechanisms behind the varying levels of HIV protection among different Lactobacillus species.
Review
Obstetrics & Gynecology
Ahinoam Lev-Sagie, Francesco De Seta, Hans Verstraelen, Gary Ventolini, Risa Lonnee-Hoffmann, Pedro Vieira-Baptista
Summary: This series of articles aims to summarize recent findings on the vaginal bacterial microbiota and its relevance to clinicians specializing in vulvovaginal disorders. The second article focuses on vaginal dysbiotic conditions, including bacterial vaginosis and other conditions associated with lactobacilli depletion. The heterogeneity and diversity within the genus Gardnerella may impact the progression of bacterial vaginosis.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Review
Medicine, General & Internal
Jose Eleuterio Jr, Adriana Bittencourt Campaner, Newton Sergio de Carvalho
Summary: The Brazilian Group for Vaginal Infections (GBIV) aimed to improve gynecological practice by developing practical algorithms for the diagnosis and treatment of vaginitis. These algorithms consider different scenarios and diagnostic tools, emphasizing the importance of medical history, gynecological examination, and complementary tests.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
David N. Fredricks, Anna Plantinga, Sujatha Srinivasan, Antoinette Oot, Andrew Wiser, Tina L. Fiedler, Sean Proll, Michael C. Wu, Jeanne M. Marrazzo
Summary: This study found that the presence or concentrations of BV-associated bacteria in the mouth, anus, labia, and vagina can predict whether women will develop BV in the future.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Ellen H. A. van den Munckhof, Rosalie L. van Sitter, Ronald F. Lamont, Saskia le Cessie, Ed J. Kuijper, Cornelis W. Knetsch, Anco Molijn, Wim G. Quint, Kim E. Boers, Maurine A. Leverstein-van Hall
Summary: This study investigated the diagnostic algorithm for abnormal vaginal discharge and found that for bacterial vaginosis, combining pH and odor test at bedside with qPCR confirmation is the best approach. The developed algorithm is sensitive, specific, and reduces the need for laboratory tests in 50% of patients with bacterial vaginosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Pharmacology & Pharmacy
Petru Chitulea, Rares Gherai, Cristian Cheta, Tania Marin Negru
Summary: This study demonstrates that vaginal administration of alpha-glyco-oligosaccharides, xylitol, and hyaluronic acid can effectively control symptoms and pathogenic microbial load in vaginal infections, as well as restore a healthy lactobacilli flora.
Article
Infectious Diseases
Jemal Yasin, Getnet Ayalew, Mulat Dagnaw, Getachew Shiferaw, Feleke Mekonnen
Summary: The study reported a high burden of bacterial vaginosis and aerobic vaginitis among women, with Enterococcus faecalis and Escherichia coli being common bacteria isolated. Additionally, antibiotics like vancomycin, cefoxitin, ciprofloxacin, clindamycin, gentamicin, and meropenem were found to have good action against the majority of bacteria isolates.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
David Pacha-Herrera, Maria P. Erazo-Garcia, Dario F. Cueva, Miguel Orellana, Pamela Borja-Serrano, Camila Arboleda, Eduardo Tejera, Antonio Machado
Summary: The vaginal microbiota plays a crucial role in protecting women, with the probiotic activity provided by individual lactobacillus species and their multi-microbial interactions. This study analyzed the prevalence of five vaginal lactobacilli among healthy women and those with bacterial vaginosis (BV) or aerobic vaginitis (AV). The findings showed that Lactobacillus acidophilus, Lactobacillus jensenii, and Lactobacillus crispatus had the highest normalized importance values in protecting against vaginal dysbiosis, with L. acidophilus and L. jensenii exhibiting statistical significance. Additionally, a strong multi-microbial consortium of L. iners, L. jensenii, L. gasseri, and L. acidophilus was found to protect against AV and BV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Xin Shen, Lin Xu, Zhiquan Zhang, Yitong Yang, Pengxian Li, Teng Ma, Shuai Guo, Lai-Yu Kwok, Zhihong Sun
Summary: Vaginitis is a common gynecological disease caused by vaginal dysbiosis. Clinical treatment using antibiotics often results in adverse reactions and relapse, while probiotics intervention can restore vaginal microbiota and alleviate bacterial vaginitis (BV). In this study, a clinical trial involving 50 BV patients was conducted to evaluate the efficacy of a postbiotic gel applied for one week. The results showed that the postbiotic gel improved symptoms of BV and increased the abundance of vaginal lactobacilli, which were negatively correlated with potential vaginal pathogens and abnormal vaginal secretions. Overall, this study provides valuable clinical data for managing BV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Infectious Diseases
Hans Verstraelen, Alexander Swidsinski
CURRENT OPINION IN INFECTIOUS DISEASES
(2019)
Letter
Obstetrics & Gynecology
Nele Brusselaers, Hans Verstraelen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Gastroenterology & Hepatology
Alasdair J. Scott, James L. Alexander, Claire A. Merrifield, David Cunningham, Christian Jobin, Robert Brown, John Alverdy, Stephen J. O'Keefe, H. Rex Gaskins, Julian Teare, Jun Yu, David J. Hughes, Hans Verstraelen, Jeremy Burton, Paul W. O'Toole, Daniel W. Rosenberg, Julian R. Marchesi, James M. Kinross
Review
Obstetrics & Gynecology
J. Norenhag, J. Du, M. Olovsson, H. Verstraelen, L. Engstrand, N. Brusselaers
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Editorial Material
Oncology
Hans Verstraelen
Letter
Obstetrics & Gynecology
Hans Verstraelen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Review
Public, Environmental & Occupational Health
Judith Brusselmans, An De Sutter, Brecht Devleesschauwer, Hans Verstraelen, Piet Cools
Summary: This review examines the association between symptomatic bacterial vaginosis (BV) and the emotional, sexual, and social health of women. The results suggest that symptomatic BV may have an impact on the emotional, sexual, and social well-being of women, but more evidence is needed to determine the extent of this association.
Article
Medicine, General & Internal
Glenn Vergauwen, Piet Cools, Hannelore Denys, Tom Fiers, Koen Van de Vijver, Liv Veldeman, Hans Verstraelen
Summary: Breast cancer is the most common cancer type in women worldwide. Endocrine therapy, which involves the use of selective estrogen receptor modulators or aromatase inhibitors, is crucial in the treatment of breast cancer. However, a common side effect of endocrine therapy is vulvovaginal atrophy, which negatively impacts patients' physical and psychological well-being.
Review
Obstetrics & Gynecology
Francesco De Seta, Risa Lonnee-Hoffmann, Giuseppina Campisciano, Manola Comar, Hans Verstraelen, Pedro Vieira-Baptista, Gary Ventolini, Ahinoam Lev-Sagie
Summary: The vaginal microbiome plays a crucial role in various urogenital disorders, including vulvovaginal candidiasis, urinary tract infections, and sexually transmitted infections. Imbalances in the vaginal microbiome increase the risk of infection. Therefore, understanding and controlling the balance of the vaginal microbiome is essential for the prevention and treatment of these diseases.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Review
Obstetrics & Gynecology
Ahinoam Lev-Sagie, Francesco De Seta, Hans Verstraelen, Gary Ventolini, Risa Lonnee-Hoffmann, Pedro Vieira-Baptista
Summary: This series of articles aims to summarize recent findings on the vaginal bacterial microbiota and its relevance to clinicians specializing in vulvovaginal disorders. The second article focuses on vaginal dysbiotic conditions, including bacterial vaginosis and other conditions associated with lactobacilli depletion. The heterogeneity and diversity within the genus Gardnerella may impact the progression of bacterial vaginosis.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Review
Obstetrics & Gynecology
Gary Ventolini, Pedro Vieira-Baptista, Francesco De Seta, Hans Verstraelen, Risa Lonnee-Hoffmann, Ahinoam Lev-Sagie
Summary: This article summarizes recent findings and understanding of the vaginal bacterial microbiota, particularly in relation to vulvovaginal disorders. The study highlights the association between altered vaginal microbiota and negative pregnancy outcomes, as well as gynecologic malignancies.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Review
Obstetrics & Gynecology
Hans Verstraelen, Pedro Vieira-Baptista, Francesco De Seta, Gary Ventolini, Risa Lonnee-Hoffmann, Ahinoam Lev-Sagie
Summary: This series of articles aims to summarize the current findings and understanding of the vaginal bacterial microbiota, with a focus on clinicians specializing in vulvovaginal disorders. Molecular techniques have advanced our understanding of vaginal health and the interactions between microorganisms inhabiting the vagina. The clinical implications of microbial community sequencing are still being determined.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Review
Obstetrics & Gynecology
Pedro Vieira-Baptista, Francesco De Seta, Hans Verstraelen, Gary Ventolini, Risa Lonnee-Hoffmann, Ahinoam Lev-Sagie
Summary: This series of articles aims to summarize the recent findings and understanding of the vaginal microbiome, mainly for clinicians specializing in vulvovaginal disorders. The available approaches for treating vaginitis or modulating the vaginal microbiome are often insufficient, and this series discusses new and alternative therapeutic modalities, as well as the challenges facing microbiome research.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Article
Psychology, Clinical
Isabelle Stuyver, Sara Somers, Veerle Provoost, Katrien Wierckx, Hans Verstraelen, Elia Wyverkens, Lien Van Glabeke, Guy T'Sjoen, Ann Buysse, Guido Pennings, Petra De Sutter
Summary: This study examined the experiences of transgender men and their cisgender female partners who requested donor conception for having children. It found that most couples intended to disclose the use of donor sperm to their future child and saw donor conception as the preferred route to become parents. Transgender individuals should be counseled about all reproductive options to make informed decisions.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2021)