Article
Nutrition & Dietetics
Maria Elisabetta Baldassarre, Massimiliano Marazzato, Marta Pensa, Maria Teresa Loverro, Michele Quercia, Francesca Lombardi, Federico Schettini, Nicola Laforgia
Summary: This study aimed to evaluate the effectiveness of a single administration of the SLAB51 probiotic formula in improving oxygenation in premature babies with respiratory distress syndrome. The results showed that the SLAB51-treated group had significantly increased SaO2 levels and SaO2/FiO2 ratio, while the control group showed no changes. Additionally, the study found that SLAB51 can enhance antioxidant responses in intestinal epithelial cells. Therefore, SLAB51 represents a promising approach to manage preterm infants requiring oxygen supplementation.
Review
Medicine, General & Internal
S. Sharif, P. T. Heath, S. J. Oddie, W. McGuire
Summary: The study aims to evaluate the effect of enteral supplementation with synbiotics versus placebo or no treatment, or versus probiotics or prebiotics alone on the risk of necrotising enterocolitis and associated morbidity and mortality in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Pediatrics
Mangesh Deshmukh, Sanjay Patole
Summary: Probiotics have been shown to reduce the risk of various diseases in preterm infants, but many are still hesitant to adopt them due to concerns about probiotic sepsis, product quality, and optimal strain selection.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Biotechnology & Applied Microbiology
Sulaiman F. Aljasir, Dennis J. D'Amico
Summary: This study demonstrates the potential of Hafnia alvei B16 to attenuate Salmonella virulence and protect against pathogen invasion of intestinal epithelial cells, thereby enhancing food safety.
Article
Microbiology
Allison K. Guitor, Efrah Yousuf, Amogelang R. Raphenya, Eileen K. Hutton, Katherine M. Morrison, Andrew G. McArthur, Gerard D. Wright, Jennifer C. Stearns
Summary: Probiotic supplementation reduces the prevalence and persistence of antibiotic resistance genes in preterm infants, improving the diversity of their gut microbiome.
Article
Health Care Sciences & Services
Jiarui Feng, Jennifer Lee, Zachary A. Vesoulis, Fuhai Li
Summary: The study demonstrates that using a deep learning model can better predict the mortality risk of preterm infants in the NICU, with superior performance compared to traditional static prediction models.
NPJ DIGITAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Rita C. Silveira, Andrea L. Corso, Renato S. Procianoy
Summary: This study examines the complex interplay between nutrition and neurodevelopment in premature infants, emphasizing the importance of tailored nutritional approaches to support optimal brain growth and function. Specific macro and micronutrients play a crucial role in promoting neurodevelopment. Early and aggressive nutrition, as well as the benefits of human milk, human milk oligosaccharides, and probiotics on neurodevelopment through the gut-brain axis, are explored. The findings highlight the significance of individualized nutritional approaches and comprehensive nutrient strategies in enhancing neurodevelopment in premature infants.
Review
Nutrition & Dietetics
Isadora Beghetti, Davide Panizza, Jacopo Lenzi, Davide Gori, Silvia Martini, Luigi Corvaglia, Arianna Aceti
Summary: This study conducted a systematic review and network meta-analysis on the role of probiotics in preventing NEC in preterm infants, demonstrating that B. lactis Bb-12/B94 could reduce the risk of NEC, with a different size effect according to feeding type. Further trials are needed to confirm these findings.
Article
Multidisciplinary Sciences
Chitong Rao, Katharine Z. Coyte, Wayne Bainter, Raif S. Geha, Camilia R. Martin, Seth Rakoff-Nahoum
Summary: The gut microbiota in preterm infants develops predictably, with the environment, host, and microorganism interactions all potentially shaping the dynamics. The study used multi-kingdom absolute abundance quantification to investigate the absolute dynamics of bacteria, fungi, and archaea in a cohort of preterm infants, uncovering microbial blooms, extinctions, and microbe-microbe interactions. The research reveals the centrality of interactions between microorganisms in shaping host-associated microbiota, providing insights for microbiota ecology and interventions.
Review
Medicine, General & Internal
Sahar Sharif, Sam J. Oddie, Paul T. Heath, William McGuire
Summary: This review aims to evaluate the effectiveness of enteral supplementation with prebiotic oligosaccharides on the risk of necrotising enterocolitis, and associated morbidity and mortality, in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
C. P. Rath, G. Athalye-Jape, E. Nathan, D. Doherty, S. Rao, S. Patole
Summary: This study compares the outcomes of preterm infants in different epochs and finds that routine probiotic supplementation has sustained benefits in reducing necrotising enterocolitis and mortality.
Article
Pediatrics
David B. Healy, Benjamin Campbell-Green, Vicki Livingstone, C. Anthony Ryan, R. Paul Ross, Catherine Stanton, Eugene M. Dempsey
Summary: The aim of this study was to evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants before and after the introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics. The results showed a reduction in the composite outcome of severe grade NEC and/or death after the introduction of routine administration of probiotics.
Article
Gastroenterology & Hepatology
Raakel Luoto, Anna Paertty, Josef K. Vogt, Samuli Rautava, Erika Isolauri
Summary: This study investigated the composition and function of the gut microbiome in moderately and late preterm infants. Probiotic and prebiotic treatments were found to mitigate the changes in the microbiome, indicating their potential in promoting healthy gut microbiome development in preterm infants.
Article
Fisheries
Puvaneswari Puvanasundram, Chou Min Chong, Suriana Sabri, Md Sabri Yusoff, Murni Karim
Summary: The use of multi-strain probiotics (MSP) in aquaculture has become a common practice over the last decade, providing more benefits to aquatic organisms through synergistic effects. The positive interrelationship among strains in MSP results in symbiosis and often leads to inhibition of pathogens and enhancement of host immunity. Various benefits of MSP include increased survival rate, improved growth parameters, and enhanced non-specific immunity in hosts. Further research is needed to explore the mechanisms and interactions among strains in MSP formulations, in order to optimize their effectiveness in aquaculture practices.
AQUACULTURE REPORTS
(2021)
Review
Medicine, General & Internal
Sahar Sharif, Paul T. Heath, Sam J. Oddie, William McGuire
Summary: Intestinal dysbiosis may contribute to the development of NEC in very preterm or very low birth weight infants. Dietary supplementation with synbiotics, which can modulate the intestinal microbiome, may reduce the risk of NEC and all-cause mortality in these infants. However, the evidence is currently limited and more high-quality trials are needed to confirm these findings.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Infectious Diseases
Luisa A. Denkel, Frank Schwab, Jorg Clausmeyer, Michael Behnke, Jennifer Golembus, Solvy Wolke, Petra Gastmeier, Christine Geffers
Summary: The study aimed to compare the effects of chlorhexidine, octenidine, or routine bathing with water and soap on CLABSI rates in ICUs. However, both antiseptic methods did not show a significant preventive effect on CLABSI rates in the ICU setting.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Public, Environmental & Occupational Health
Seven Johannes Sam Aghdassi, Frank Schwab, Luis Alberto Pena Diaz, Annika Brodzinski, Giovanni-Battista Fucini, Sonja Hansen, Britta Kohlmorgen, Brar Piening, Beate Schlosser, Sandra Schneider, Beate Weikert, Miriam Wiese-Posselt, Sebastian Wolff, Michael Behnke, Petra Gastmeier, Christine Geffers
Summary: By analyzing data on nosocomial SARS-CoV-2 infections at Charite university hospital in Berlin, it was found that contact with SARS-CoV-2 cases and being at a ward with a SARS-CoV-2 outbreak were the main risk factors for nosocomial infections.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Health Care Sciences & Services
Stefan Buchholtz, Laura Fangmann, Nina Siedentopf, Christoph Buehrer, Lars Garten
Summary: This study retrospectively analyzed the characteristics of patients referred for prenatal palliative care counseling at Charite Universitatsmedizin Berlin, Germany, evaluated pregnancy outcomes, and analyzed the additional human resources required for specialized PnPC services. The results confirmed previous observations regarding diagnoses, referrals, and outcomes. The provision of specialized and interprofessional PnPC services required approximately 14 hours per case of additional human resources.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Infectious Diseases
Katharina Ginter, Frank Schwab, Michael Behnke, Martin Wolkewitz, Petra Gastmeier, Christine Geffers, Friederike Maechler
Summary: This study evaluated the usefulness of SAPS2, APACHE2, Core-10-TISS, and SOFA scores in assessing a patient's risk of ICU-acquired infection. The results showed that these scores can be adequate indicators for predicting the risk of ICU-acquired infection in patients.
Article
Medicine, General & Internal
Auss Abbood, Alexander Ullrich, Luisa A. Denkel
Summary: Most countries report COVID-19 cases when they have cases to report, but some countries have unusual or highly irregular reporting. Our score system and cluster analyses can help epidemiologists advise policy makers on country-specific reporting behaviors.
Review
Pediatrics
Kerstin von der Hude, Lars Garten
Summary: Against the backdrop of a society that fails to recognize the sorrow endured by parents who have lost premature infants, this article presents the SORROWFUL model to highlight the significance of newborn death for affected families. This model serves as a support tool in counseling parents who are grieving the impending or actual loss of a child during pregnancy or neonatal life, and can be applied from the initial diagnosis through the period following the child's death. The model intentionally allows for cultural and individual adaptation to meet the diverse needs of affected parents and available local resources.
Article
Pediatrics
Lars Garten, Kerstin von der Hude
Summary: Palliative care in the delivery room is a challenging task involving the dying newborn, parents, and caregivers. It differs from palliative care in the neonatal intensive care unit. This article provides background information and practical recommendations for perinatal palliative care in the delivery room, covering various aspects such as symptom control, emotional support for parents, and self-care for medical personnel.
Article
Infectious Diseases
Peter Bischoff, Tobias Siegfried Kramer, Christin Schroeder, Michael Behnke, Frank Schwab, Christine Geffers, Petra Gastmeier, Seven Johannes Sam Aghdassi
Summary: This study investigated the correlation between age and surgical site infection (SSI) occurrence, and found that older age is associated with a higher risk of SSI.
Article
Public, Environmental & Occupational Health
Luisa Denkel, Frank Schwab, Joerg Clausmeyer, Michael Behnke, Jennifer Golembus, Solvy Wolke, Petra Gastmeier, Christine Geffers
Summary: An analysis of a cluster randomised controlled trial revealed that antiseptic bathing did not reduce central-line associated bloodstream infection (CLABSI) rates in intensive care units (ICU). However, this analysis did not consider baseline infection rates. A post-hoc analysis of the trial showed that daily bathing with chlorhexidine reduced ICU-attributable CLABSI rates caused by gram-positive bacteria, while octenidine did not have a significant effect.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Review
Microbiology
Robin Koeck, Luisa Denkel, Andrea T. Fessler, Rudolf Eicker, Alexander Mellmann, Stefan Schwarz, Christine Geffers, Nils-Olaf Huebner, Rasmus Leistner
Summary: This article reviews clinical studies on the effects of octenidine dihydrochloride (OCT) as an antiseptic agent. It reveals that OCT has certain effects in decolonizing Staphylococcus aureus, preventing surgical site infections (SSIs), and preventing ICU or catheter-related bloodstream and insertion site infections.
Article
Infectious Diseases
Anna M. Rohde, Alexander Mischnik, Michael Behnke, Ariane Dinkelacker, Simone Eisenbeis, Jane Falgenhauer, Petra Gastmeier, Georg Haecker, Susanne Herold, Can Imirzalioglu, Nadja Kaeding, Evelyn Kramme, Silke Peter, Ellen Piepenbrock, Jan Rupp, Christian Schneider, Frank Schwab, Harald Seifert, Michaela Steib-Bauert, Evelina Tacconelli, Janina Trauth, Maria J. G. T. Vehreschild, Sarah Walker, Winfried Kern, Nathalie Jazmati, DZIF R NET Study Grp
Summary: This study analysed the influence of antibiotic consumption on healthcare-associated healthcare onset Clostridioides difficile infection (CDI) in a German university hospital setting. The findings showed that carbapenem (mostly meropenem) consumption was associated with an increased incidence density of HAHO-CDI, particularly in haematology-oncology wards. Other patient-specific factors and ward specialty were equally important in controlling HAHO-CDI.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Critical Care Medicine
Rasmus Leistner, Lisa Schroeter, Thomas Adam, Denis Poddubnyy, Miriam Stegemann, Britta Siegmund, Friederike Maechler, Christine Geffers, Frank Schwab, Petra Gastmeier, Sascha Treskatsch, Stefan Angermair, Thomas Schneider
Summary: This study found a significant increase in the risk of COVID-19-associated pulmonary aspergillosis (CAPA) with the use of recommended dexamethasone therapy for COVID-19 treatment.
