Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

Chikungunya: Evolutionary history and recent epidemic spread

(2015) Scott C. Weaver et al.   ANTIVIRAL RESEARCH

Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses

(2015) Tero Ahola et al.   Biology Direct

Chikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein response

(2015) Jelke J. Fros et al.   JOURNAL OF GENERAL VIROLOGY

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

(2015) Bastian Thaa et al.   JOURNAL OF VIROLOGY

Stress Granule Components G3BP1 and G3BP2 Play a Proviral Role Early in Chikungunya Virus Replication

(2015) Florine E. M. Scholte et al.   JOURNAL OF VIROLOGY

Therapeutics and Vaccines Against Chikungunya Virus

(2015) Tero Ahola et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation

(2015) Marc D. Panas et al.   PLoS Pathogens

Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2

(2015) Age Utt et al.   JOURNAL OF VIROLOGY

Functional Cross-talk between Distant Domains of Chikungunya Virus Non-structural Protein 2 Is Decisive for Its RNA-modulating Activity

(2014) Pratyush Kumar Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus Replication

(2014) Melanie McFarlane et al.   PLoS Neglected Tropical Diseases

Presentation Overrides Specificity: Probing the Plasticity of Alphaviral Proteolytic Activity through Mutational Analysis

(2013) V. Lulla et al.   JOURNAL OF VIROLOGY

Novel Attenuated Chikungunya Vaccine Candidates Elicit Protective Immunity in C57BL/6 mice

(2013) D. Hallengard et al.   JOURNAL OF VIROLOGY

The C-Terminal Domain of Chikungunya Virus nsP2 Independently Governs Viral RNA Replication, Cytopathicity, and Inhibition of Interferon Signaling

(2013) J. J. Fros et al.   JOURNAL OF VIROLOGY

Stable, High-Level Expression of Reporter Proteins from Improved Alphavirus Expression Vectors To Track Replication and Dissemination during Encephalitic and Arthritogenic Disease

(2013) C. Sun et al.   JOURNAL OF VIROLOGY

Template RNA Length Determines the Size of Replication Complex Spherules for Semliki Forest Virus

(2013) K. Kallio et al.   JOURNAL OF VIROLOGY

Subgenomic Reporter RNA System for Detection of Alphavirus Infection in Mosquitoes

(2013) J. Jordan Steel et al.   PLoS One

BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1)

(2013) Philip H. Jones et al.   VIROLOGY

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

(2013) Abhay P S Rathore et al.   Virology Journal

Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout

(2013) Sabine Gläsker et al.   Virology Journal

RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication

(2013) Andrei Nikonov et al.   PLoS Pathogens

Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

(2012) J. J. Fros et al.   JOURNAL OF VIROLOGY

Evasion of the Innate Immune Response: the Old World Alphavirus nsP2 Protein Induces Rapid Degradation of Rpb1, a Catalytic Subunit of RNA Polymerase II

(2012) I. Akhrymuk et al.   JOURNAL OF VIROLOGY

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

(2012) Marc D. Panas et al.   MOLECULAR BIOLOGY OF THE CELL

Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level

(2012) Lia E. Gracey Maniar et al.   MOLECULAR THERAPY

Macromolecular Assembly-Driven Processing of the 2/3 Cleavage Site in the Alphavirus Replicase Polyprotein

(2011) A. Lulla et al.   JOURNAL OF VIROLOGY

Assembly of Alphavirus Replication Complexes from RNA and Protein Components in a Novel trans-Replication System in Mammalian Cells

(2011) P. Spuul et al.   JOURNAL OF VIROLOGY

NTPase and 5′-RNA Triphosphatase Activities of Chikungunya Virus nsP2 Protein

(2011) Yogesh A. Karpe et al.   PLoS One

Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays

(2011) Leena Pohjala et al.   PLoS One

SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication

(2011) Maarit Neuvonen et al.   PLoS Pathogens

Antiviral RNA Interference Responses Induced by Semliki Forest Virus Infection of Mosquito Cells: Characterization, Origin, and Frequency-Dependent Functions of Virus-Derived Small Interfering RNAs

(2010) R. W. C. Siu et al.   JOURNAL OF VIROLOGY

Host Factors Associated with the Sindbis Virus RNA-Dependent RNA Polymerase: Role for G3BP1 and G3BP2 in Virus Replication

(2010) I. M. Cristea et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol 3-Kinase-, Actin-, and Microtubule-Dependent Transport of Semliki Forest Virus Replication Complexes from the Plasma Membrane to Modified Lysosomes

(2010) P. Spuul et al.   JOURNAL OF VIROLOGY

Functional Sindbis Virus Replicative Complexes Are Formed at the Plasma Membrane

(2010) E. I. Frolova et al.   JOURNAL OF VIROLOGY

Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling

(2010) Jelke J. Fros et al.   JOURNAL OF VIROLOGY

A robust system for production of minicircle DNA vectors

(2010) Mark A Kay et al.   NATURE BIOTECHNOLOGY

Novel Functions of the Alphavirus Nonstructural Protein nsP3 C-Terminal Region

(2009) M. Varjak et al.   JOURNAL OF VIROLOGY

Fate of Minus-Strand Templates and Replication Complexes Produced by a P23-Cleavage-Defective Mutant of Sindbis Virus

(2009) J. Mai et al.   JOURNAL OF VIROLOGY

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

(2009) H. Malet et al.   JOURNAL OF VIROLOGY

Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus

(2008) K. Tamm et al.   JOURNAL OF GENERAL VIROLOGY

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro

(2008) Jon K. Rubach et al.   VIROLOGY