Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response

Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis

(2014) Tue W Kragstrup et al.   ARTHRITIS RESEARCH & THERAPY

Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial

(2013) Kim Hørslev-Petersen et al.   ANNALS OF THE RHEUMATIC DISEASES

Review: Treat to Target in Rheumatoid Arthritis: Fact, Fiction, or Hypothesis?

(2013) Daniel H. Solomon et al.   Arthritis & Rheumatology

A simple set of validation steps identifies and removes false results in a sandwich enzyme-linked immunosorbent assay caused by anti-animal IgG antibodies in plasma from arthritis patients

(2013) Tue W Kragstrup et al.   SpringerPlus

Next stage of RA treatment: is TNF inhibitor-free remission a possible treatment goal?

(2012) Yoshiya Tanaka   ANNALS OF THE RHEUMATIC DISEASES

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis

(2012) William P. Arend et al.   Nature Reviews Rheumatology

SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes

(2012) Kresten Krarup Keller et al.   RHEUMATOLOGY INTERNATIONAL

Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis

(2012) Luis Chara et al.   ARTHRITIS RESEARCH & THERAPY

Suppression of endothelial cell activity by inhibition of tumor necrosis factor-alpha

(2012) Qiang Shu et al.   ARTHRITIS RESEARCH & THERAPY

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis

(2011) K. Zen et al.   BLOOD

Metalloproteinase-mediated Shedding of Integrin β2 Promotes Macrophage Efflux from Inflammatory Sites

(2011) Ivan G. Gomez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrins and their ligands in rheumatoid arthritis

(2011) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

An LFA-1 ( L 2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis

(2010) S. J. Suchard et al.   JOURNAL OF IMMUNOLOGY

Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure

(2010) L. C. Gjelstrup et al.   JOURNAL OF IMMUNOLOGY

Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

(2010) Scott H. Watterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Progressive Multifocal Leukoencephalopathy in Patients on Immunomodulatory Therapies

(2009) Eugene O. Major   Annual Review of Medicine

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

MMP-9 Sheds the β2Integrin Subunit (CD18) from Macrophages

(2008) Tomáš Vaisar et al.   MOLECULAR & CELLULAR PROTEOMICS