Article
Biochemistry & Molecular Biology
Ahasanul Hasan, Raquibul Hasan
Summary: Empagliflozin induces vasodilation in rat mesenteric arteries by stimulating smooth muscle cell K-V channels, specifically K(V)1.5 and K(V)7. Inhibition of vasodilatory signaling axes and prostacyclin does not affect empagliflozin-induced vasodilation, indicating a novel mechanism for arterial relaxation. These findings suggest that empagliflozin may have potential as a complementary treatment for hypertension due to its effects on arterial contractility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Paz Duran, Santiago Loya-Lopez, Dongzhi Ran, Cheng Tang, Aida Calderon-Rivera, Kimberly Gomez, Harrison J. Stratton, Sun Huang, Ya-ming Xu, E. M. Kithsiri Wijeratne, Samantha Perez-Miller, Zhiming Shan, Song Cai, Anna T. Gabrielsen, Angie Dorame, Kyleigh A. Masterson, Omar Alsbiei, Cynthia L. Madura, Guoqin Luo, Aubin Moutal, John Streicher, Gerald W. Zamponi, A. A. Leslie Gunatilaka, Rajesh Khanna
Summary: This study identified argentatin C, a compound derived from the Native American medicinal plant Parthenium incanum, which can block the activity of voltage-gated sodium and calcium channels and has potential as a novel treatment for painful conditions. Experimental results demonstrated that argentatin C decreased ion currents and excitability in sensory neurons and relieved postsurgical pain in a mouse model. Therefore, argentatin C may serve as an alternative therapy for chronic pain management.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ahasanul Hasan, Sreelakshmi N. Menon, Farzana Zerin, Raquibul Hasan
Summary: The study found that dapagliflozin can directly relax small mesenteric arteries that control peripheral vascular resistance and blood pressure. This vasodilatory effect is mediated by the stimulation of arterial smooth muscle cells' K(V)7 channels. The findings are significant for understanding the mechanism of dapagliflozin in reducing systemic blood pressure.
Review
Biochemistry & Molecular Biology
Silvia Cassinelli, Carla Vinola-Renart, Anna Benavente-Garcia, Maria Navarro-Perez, Jesusa Capera, Antonio Felipe
Summary: Protein lipidation is a common form of posttranslational modification that regulates various aspects of a protein's physiology, including its structure, stability, and interaction with cellular membranes. Palmitoylation, the addition of long saturated fatty acid chains to proteins, is a key form of lipidation. Enzymes called acyltransferases and thioesterases control the behavior of palmitoylated proteins through a series of acylation and deacylation cycles. Palmitoylation plays a pleiotropic role in regulating the trafficking, spatial organization, and electrophysiological properties of ion channels, particularly voltage-gated ion channels (VGICs). Dysregulation of palmitoylation in VGICs and associated subunits is linked to the development of diseases such as cancer and mental disorders. Therefore, protein palmitoylation is emerging as an important factor in cellular protein regulation and human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Bing Hua, Qingbo Liu, Side Gao, Weiping Li, Hongwei Li
Summary: The study explored the role and mechanism of PPAR gamma in AGEs-induced impairment of coronary artery vasodilation. The findings revealed that activating PPAR gamma can prevent Kv 1 channel impairment, improve protein expression, and enhance coronary artery vasodilation. Additionally, PPAR gamma activation can reduce AGEs-mediated ROS production and oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Samantha Edenfield, Abigail M. Sims, Constance Porretta, Harry J. Gould, Dennis Paul
Summary: This study demonstrated that the expression of VGSCs doubles during the preparation phase of cell division, while the expression of Na+,K+-ATPase only increases by 1.5 times. This finding has important implications for understanding the role of sodium in cell cycle control and the variability of treatments targeting these components of the Na+ handling system.
Article
Neurosciences
Victoria Gonzalez Sabater, Mark Rigby, Juan Burrone
Summary: In this study, the initiation and propagation of action potentials (APs) along the axon were investigated using genetically encoded voltage indicators (GEVIs) in dissociated hippocampal neurons from rat embryos. It was found that APs became sharper and exhibited greater fidelity as they traveled towards distal axonal domains. Blocking voltage-gated potassium channels (K-v) resulted in an increase in AP width, especially in distal locations, suggesting that higher levels of Kv channel activity in distal axons contribute to maintaining AP fidelity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Lize Evens, Ellen Heeren, Jean-Luc Rummens, Annelies Bronckaers, Marc Hendrikx, Dorien Deluyker, Virginie Bito
Summary: In vitro studies showed that AGEs have a time- and concentration-dependent negative effect on CASCs survival, proliferation, migration, and apoptosis, partially mediated through RAGE activation. The potential of anti-AGEs therapies in the context of stem cell therapy after MI requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Ksenia S. Kudryashova, Oksana V. Nekrasova, Mikhail P. Kirpichnikov, Alexey V. Feofanov
Summary: This review discusses the construction of chimeric potassium channels KcsA-Kv1, their applications in studying interactions of pore blockers, and their role in determining molecular basis for high affinity and selectivity of binding of peptide blockers to Kv1 channels.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Chemistry, Multidisciplinary
Jingxia Han, Yu Sun, Ting Wu, Xiaohui Hou, Shaoting Zheng, Haohao Zhang, Tingting Lin, Huijuan Liu, Tao Sun
Summary: In this study, echinacoside-zinc coordination polymers (ECH-Zn) were synthesized and further wrapped in hyaluronic acid/poly(ethylenimine) (HA-PEI) nanoparticles to obtain HA-PEI-coated ECH-Zn (PPZn) nanoparticles. The PPZn nanoparticles showed better antiglycation effects in the skin and enhanced the uptake and utilization of ECH-Zn. Mechanistic studies revealed that MDM2 can interact with STAT2 to promote RAGE transcriptional activation, while PPZn can inhibit the expression and interaction of the MDM2/STAT2 complex, leading to the suppression of RAGE transcriptional activation and exerting antiglycation effects.