Article
Biophysics
Leqian Zhao, Xingliang Fu, Liyuan Zhang, Zhiyi Ye
Summary: Mechanical properties play crucial roles in the immune system, affecting the activation, transformation, and effector responses of immune cells. This study investigated the elasticity of Jurkat cells and the adhesion properties between integrins and VCAM-1 using atomic force microscopy. The results demonstrated the relationship between cytoskeleton and integrin-ligand through mechanical characteristics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Elenilze F. B. Ferreira, Luciane B. Silva, Josiane Cruz, Pedro H. F. Araujo, Njogu M. Kimani, Franco H. A. Leite, Joaquin M. Campos, Cleydson B. R. Santos
Summary: This article presents a simplified view of integrins, with a focus on alpha 4 integrin. Integrins are heterodimeric proteins expressed on the cell surface, playing a role in various cellular functions and responding to changes in the extracellular environment, forming a physical connection between the interior and exterior of the cell.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Liangqingqing Yin, Jie Bai, Wei-Jia Yu, Ying Liu, Hui-Hua Li, Qiu-Yue Lin
Summary: The adhesion of monocytes to the vascular endothelium is an important factor in inflammatory response and contributes to hypertension and vascular remodeling. The role of VCAM-1 in Ang II-induced hypertension and vascular dysfunction is not well understood. Blocking VCAM-1 with a neutralizing antibody can alleviate these effects and represents a novel therapeutic approach for hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Chiara Camillo, Nicola Facchinello, Giulia Villari, Giulia Mana, Noemi Gioelli, Chiara Sandri, Matteo Astone, Dora Tortarolo, Fabiana Clapero, Dafne Gays, Roxana E. Oberkersch, Marco Arese, Luca Tamagnone, Donatella Valdembri, Massimo M. Santoro, Guido Serini
Summary: Dynamic modulation of endothelial cell adhesion and barrier function by the adhesion G protein-coupled receptor Latrophilin 2 (LPHN2) and its ligand FLRT2 plays a crucial role in blood vessel development and functioning.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Su Jeong Ha, Min Jeong Kim, Joon Park, Hyun-Wook Choi, Hyunjong Yu, Pahn-Shick Chang, Sung Keun Jung
Summary: EL exhibits anti-inflammatory effects by inhibiting cell adhesion, protein phosphorylation, and gene expression induced by inflammatory mediators. By modulating cell signaling pathways, it can suppress the expression of inflammatory factors.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Oncology
Manali Tilak, Begum Alural, Sarah E. Wismer, Megan I. Brasher, Laura A. New, Steven D. Sheridan, Roy H. Perlis, Marc G. Coppolino, Jasmin Lalonde, Nina Jones
Summary: This study identified the upregulation of ShcD in malignant gliomas and its association with Tie2 receptor tyrosine kinase to promote invasion. The expression of ShcD and Tie2 in glioma cells enhances invasion, with ShcD mutant disrupting the synergistic effect. The elevated expression of ShcD correlates with poor patient outcomes in advanced gliomas.
MOLECULAR CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hongfei Liu, Jiankun Liu, Changkun Long, Liping Chen, Wenxing Zhan, Wanli Xiao, Xueting Gong, Man Liu, Xiao-Li Tian, Shenghan Chen
Summary: The study revealed that NPR1 deficiency increases vascular endothelial cell adhesion by stimulating ITGB4 expression, which may contribute to the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell & Tissue Engineering
Ye Ran, Yankai Dong, Yuejiao Li, Jundong Xie, Shubin Zeng, Chuanlei Liang, Wei Dai, Wenjing Tang, Yaojiong Wu, Shengyuan Yu
Summary: Aggregation of 2D cultured MSCs mediated by the interaction of integrin alpha 4 and VCAM-1 poses a potential risk of cerebrospinal fluid obstruction after intrathecal transplantation. Blockade of VCAM-1 can reduce aggregation and alleviate ventricular dilation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Geriatrics & Gerontology
Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
Summary: In patients with nAMD, levels of VCAM-1 were significantly elevated in those with macular fibrosis and correlated with retinal thickness. VCAM-1 was highly expressed at the site of fibrosis in a mouse model. Blocking VCAM-1 prevented macrophage infiltration and reduced subretinal fibrosis. VCAM-1 induced macrophage migration and influenced the expression of various genes involved in fibrosis.
Review
Cell Biology
Soren Egstrand, Maria L. Mace, Klaus Olgaard, Ewa Lewin
Summary: Chronic kidney disease is associated with high cardiovascular mortality and disruption of circadian rhythms in the vasculature, potentially contributing to uremic vasculopathy.
Review
Immunology
Kristoffer H. Johansen, Dominic P. Golec, Julie H. Thomsen, Pamela L. Schwartzberg, Klaus Okkenhaug
Summary: PI3K signaling is crucial for T cell activation, differentiation, and trafficking, with PI3K delta being the dominant isoform in T cells. It regulates T cell functions by controlling adhesion receptors and their interaction with antigen-presenting cells. Understanding the role of PI3K delta in T cell migration and localization is important for potential impacts of PI3K delta inhibitors on T cell redistribution and function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Warkala, Dongying Chen, AnnJosette Ramirez, Ali Jubran, Michael Schonning, Xia Wang, Huaning Zhao, Sophie Astrof
Summary: The development of the fourth pharyngeal arch arteries involves a multistep process with contributions from SHF-derived ECs, remodeling of endothelial plexus into PAAs, and remodeling of PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin alpha 5 beta 1 and Fn1 are essential at each developmental stage.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jennifer E. Chung, Wendy Magis, Jonathan Vu, Seok-Jin Heo, Kirmo Wartiovaara, Mark C. Walters, Ryo Kurita, Yukio Nakamura, Dario Boffelli, David I. K. Martin, Jacob E. Corn, Mark A. Dewitt
Article
Multidisciplinary Sciences
Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Article
Cell & Tissue Engineering
Mika Suga, Takayuki Kondo, Keiko Imamura, Ran Shibukawa, Yasue Okanishi, Yukako Sagara, Kayoko Tsukita, Takako Enami, Mahoko Furujo, Kaoru Saijo, Yukio Nakamura, Mitsujiro Osawa, Megumu K. Saito, Shinya Yamanaka, Haruhisa Inoue
STEM CELL RESEARCH
(2019)
Article
Urology & Nephrology
Kei Nagai, Mamiko Iwase, Atsushi Ueda
Summary: A 70-year-old woman developed anti-glomerular basement membrane glomerulonephritis after centipede bites and COVID-19 vaccination. Both vaccination and animal bites may induce Th1 immunity, contributing to the development of necrotizing GN. The case suggests an increased risk of anti-GBM GN caused by excessively induced Th1 immunity from both vaccination and animal bites.
Letter
Urology & Nephrology
Kei Nagai, Mikiko Kageyama, Mamiko Iwase, Atsushi Ueda
Letter
Urology & Nephrology
Kei Nagai, Atsushi Ueda
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Letter
Hematology
Kei Nagai, Yoshiharu Nakamura
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Engineering, Biomedical
Kei Nagai, Atsushi Ueda
Summary: This study investigated the effects of proactive combination dialysis therapy on peritoneal dialysis and residual renal function. The observation results showed that patients who started with proactive combination therapy had better technical survival of peritoneal dialysis and improved urinary volume and creatinine clearance as residual renal function compared to patients who received peritoneal monotherapy.
JOURNAL OF ARTIFICIAL ORGANS
(2023)
Review
Medicine, General & Internal
Kei Nagai
Summary: Therapeutic options for glomerular diseases have expanded with improvements to KDIGO guidelines, but access to expensive treatments like rituximab is limited in some countries. This review explores the possible applications of immunosuppressive agents for nephrotic syndrome based on international guidelines. While rituximab is currently the mainstay of treatment, other options such as cyclophosphamide and calcineurin inhibitors may be preferable. Cost-effectiveness and further large-scale studies are needed to verify the efficacy of rituximab and other treatments for nephrotic syndrome.
MEDICINA-LITHUANIA
(2023)
Review
Urology & Nephrology
Kei Nagai, Shiho Kosaka, Yuka Kawate, Norihiro Itsubo
Summary: Global warming may lead to reduced food production and unhealthy dietary habits, which could contribute to the development of chronic kidney disease. Adopting diets such as plant-based and low-protein diets can not only prevent the progression of kidney disease, but also have environmental benefits. Traditional Japanese diets, such as washoku and the Okinawa diet, have been proposed as potential solutions, but modifications are needed to suit modern lifestyles.
RENAL REPLACEMENT THERAPY
(2022)
Review
Urology & Nephrology
Kei Nagai
Summary: The prevalence of chronic kidney disease is increasing globally, with high rates reported among young and middle-aged men working in agricultural communities in Central America and South Asia. The disease, known as chronic interstitial nephritis in agricultural communities (CINAC), develops without classical risk factors, potentially due to heat stress and exposure to agrochemicals. Global warming and environmental pollution pose a significant health risk to farmers, especially during heat stress while working on farms.
RENAL REPLACEMENT THERAPY
(2021)
Review
Urology & Nephrology
Kei Nagai, Katherine Barraclough, Atsushi Ueda, Norihiro Itsubo
Summary: Climate change is increasingly affecting kidney health, leading to a growing focus on Green Nephrology in countries like Australia and the UK. Awareness about environmental issues in healthcare is rising, with efforts to reduce carbon footprint and promote environmental sustainability in the kidney healthcare sector.
RENAL REPLACEMENT THERAPY
(2021)
Review
Urology & Nephrology
Kei Nagai
Summary: NK cells, which are essential in defense against infections and tumors, decrease in both number and cytotoxicity in patients with ESKD undergoing hemodialysis. This decrease might increase susceptibility to viral infections and cancer development. While NK cell numbers may predict outcomes in renal transplantation, further research is needed to clarify the clinical significance of NK cell dysfunction in dialysis patients.
RENAL REPLACEMENT THERAPY
(2021)
Letter
Medicine, General & Internal
Kei Nagai, Takahiro Hosoi, Kentaro Nakajima, Teiko Arai, Yoshiharu Nakamura
JOURNAL OF GENERAL AND FAMILY MEDICINE
(2020)
Article
Immunology
Yu-Hsien Lin, Satoko Tahara-Hanaoka, Kei Nagai, Soichiro Yoshikawa, Masato Kubo, Shiro Shibayama, Hajime Karasuyama, Akira Shibuya
INTERNATIONAL IMMUNOLOGY
(2020)