Review
Oncology
Mike Dorothea, Jia Xie, Stephanie Pei Tung Yiu, Alan Kwok Shing Chiang
Summary: This review summarizes the oncogenic roles of Epstein-Barr virus (EBV) lytic proteins, which are expressed during the latent and lytic replication cycles of the virus, and categorizes them based on the cancer hallmarks displayed. The oncogenic properties of several EBV lytic proteins are postulated by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.
Review
Oncology
Merrin Man Long Leong, Maria Li Lung
Summary: Epstein-Barr virus (EBV) infection is associated with various malignancies and can disrupt epigenetic regulation, influencing the development of cancer. The interaction between EBV and the host genome in different cancer types results in unique epigenetic features, suggesting that EBV may utilize different latency proteins to manipulate the epigenetic modulators in host cells for pathogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Virology
Xueyi Zheng, Yuhua Huang, Kai Li, Rongzhen Luo, Muyan Cai, Jingping Yun
Summary: The Epstein-Barr virus (EBV) shapes an immunosuppressive tumor microenvironment (TME) by influencing and interacting with different components in the TME, and different EBV-associated malignancies adopt similar but slightly specific immunosuppressive mechanisms. Strategies reversing the immunosuppressive TME of EBV-associated malignancies are being evaluated in clinical practice.
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Virology
Julien Lupo, Mansour Tsougaev, Stephane Blachier, Guillaume Chovelon, Aurelie Truffot, Corentin Leroy, Joris Giai, Olivier Epaulard, Raphaele Germi, Patrice Morand
Summary: This study compared the performance of two immunoassays for detecting serological markers of EBV infection. The results showed a high agreement between the two methods, but differences were found in sensitivity and detection rates for early primary infection and past infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Medicine, Research & Experimental
Haiqi Tan, Yibing Gong, Yi Liu, Jingyi Long, Qingshuang Luo, Oluwasijibomi Damola Faleti, Xiaoming Lyu
Summary: This review discusses the widespread presence of Epstein-Barr virus (EBV) in lymphomas and epithelial cell cancers. The virus establishes two separate infection phases, latent and lytic, in the host. While the carcinogenic role of latent EBV infection has been established, recent research suggests that lytic reactivation also plays a significant role in carcinogenesis. The mechanism of EBV reactivation and the role of viral lytic antigens in tumor formation are summarized, along with the potential treatment options.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Hematology
Nader Kim El-Mallawany, Choladda V. Curry, Carl E. Allen
Summary: Epstein-Barr virus (EBV) is associated with various presentations of haemophagocytic lymphohistiocytosis (HLH), which can be life-threatening. Patients may have genetic defects or underlying infection/malignancy, with EBV playing a significant role. Increased awareness and understanding of EBV-related complications are crucial for improving survival rates.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Praphatson Malat, Tipaya Ekalaksananan, Chukkris Heawchaiyaphum, Supawadee Suebsasana, Sittiruk Roytrakul, Yodying Yingchutrakul, Chamsai Pientong
Summary: Andrographolide inhibits the reactivation of Epstein-Barr virus in EBV-positive cancer cells by inhibiting EBV lytic genes, possibly through histone modifications.
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Immunology
Antonella Farina, Edoardo Rosato, Michael York, Benjamin E. Gewurz, Maria Trojanowska, Giuseppina Alessandra Farina
Summary: Microvascular injury is considered an initial event in the pathogenesis of scleroderma, with endothelial cells suspected of being the target of autoimmune processes. EBV is proposed as a trigger for autoimmune diseases, including scleroderma, and this study reports EBV lytic antigens detected in dermal vessels of scleroderma patients. EBV DNA load is significantly increased in peripheral blood, plasma, and monocytes of scleroderma patients compared to healthy carriers, and monocytes are identified as the primary infected cell subset. Additionally, EBV is shown to infect endothelial cells via human monocytes and induce an innate immune response, potentially leading to vascular injury in scleroderma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Article
Virology
Dinesh Verma, Trenton Mel Church, Sankar Swaminathan
Summary: Understanding the factors that affect the infectivity of SARS-CoV-2 is crucial in combating COVID-19. This study showed that Epstein-Barr virus (EBV) infection induced ACE2 expression in epithelial cells, increasing susceptibility to SARS-CoV-2. The EBV transcriptional activator Zta directly activated the ACE2 promoter, and inhibiting EBV replication may reduce susceptibility to SARS-CoV-2.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Diana A. Dominguez-Martinez, Jose I. Fontes-Lemus, Alejandro Garcia-Regalado, Angel Juarez-Flores, Ezequiel M. Fuentes-Panana
Summary: Helicobacter pylori and EBV are major risk factors for gastric cancer, and both can establish persistent infections and are considered carcinogenic. The study suggests that Helicobacter pylori infection facilitates the chemoattraction of EBV-infected B lymphocytes to the gastric mucosa, with IL-8 being identified as a powerful chemoattractant and CXCR2 as the main IL-8 receptor induced by EBV. Inhibition of IL-8 and CXCR2 reduces the chemoattraction of EBV-infected B lymphocytes, indicating an interaction mechanism between Helicobacter pylori and EBV.
Article
Virology
Wiyada Wongwiwat, Benjamin Fournier, Irene Bassano, Amr Bayoumy, Claudio Elgueta Karstegl, Christine Styles, Ray Bridges, Christelle Lenoir, David BoutBoul, Despina Moshous, Benedicte Neven, Teru Kanda, Rhys G. Morgan, Robert E. White, Sylvain Latour, Paul J. Farrell
Summary: EBV plays a role in several types of human cancer, particularly in diseases involving T or NK cells. The study found large deletions in EBV genomes in some cases, with different patterns of deletions in each patient. Additionally, genome polymorphisms in EBV reflect the geographic origin of the patients.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Kwai Fung Hui, Tsz Fung Chan, Wanling Yang, Jiangshan Jane Shen, Ki Pui Lam, Hin Kwok, Pak C. Sham, Sai Wah Tsao, Dora L. Kwong, Maria Li Lung, Alan Kwok Shing Chiang
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Multidisciplinary Sciences
Weitao Lin, Yim Ling Yip, Lin Jia, Wen Deng, Hong Zheng, Wei Dai, Josephine Mun Yee Ko, Kwok Wai Lo, Grace Tin Yun Chung, Kevin Y. Yip, Sau-Dan Lee, Johnny Sheung-Him Kwan, Jun Zhang, Tengfei Liu, Jimmy Yu-Wai Chan, Dora Lai-Wan Kwong, Victor Ho-Fun Lee, John Malcolm Nicholls, Pierre Busson, Xuefeng Liu, Alan Kwok Shing Chiang, Kwai Fung Hui, Hin Kwok, Siu Tim Cheung, Yuk Chun Cheung, Chi Keung Chan, Bin Li, Annie Lai-Man Cheung, Pok Man Hau, Yuan Zhou, Chi Man Tsang, Jaap Middeldorp, Honglin Chen, Maria Li Lung, Sai Wah Tsao
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Stephanie Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Chi Wang Ma, Dan Yang, Alan Kwok Shing Chiang
Review
Oncology
Kwai Fung Hui, Stephanie Pei Tung Yiu, Kam Pui Tam, Alan Kwok Shing Chiang
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Stephanie Pei Tung Yiu, Kwai Fung Hui, Christian Muenz, Kwok-Wai Lo, Sai Wah Tsao, Richard Yi Tsun Kao, Dan Yang, Alan Kwok Shing Chiang
Article
Immunology
Janice K. P. Lam, Tarik Azzi, K. F. Hui, Aikha M. G. Wong, Donal McHugh, Nicole Caduff, K. H. Chan, Christian Munz, Alan K. S. Chiang
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Oncology
Stephanie Pei Tung Yiu, Mike Dorothea, Kwai Fung Hui, Alan Kwok Shing Chiang
Article
Biology
Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W. Keller, Anita Murer, Bithi Chatterjee, Julia Ruehl, Christine Engelmann, Obinna Chijioke, Isaak Quast, Mohaned Shilaih, Victoria P. Strouvelle, Kathrin Neumann, Thomas Menter, Stephan Dirnhofer, Janice Kp Lam, Kwai F. Hui, Simon Bredl, Erika Schlaepfer, Silvia Sorce, Andrea Zbinden, Riccarda Capaul, Jan D. Luenemann, Adriano Aguzzi, Alan K. S. Chiang, Werner Kempf, Alexandra Trkola, Karin J. Metzner, Markus G. Manz, Adam Grundhoff, Roberto F. Speck, Christian Muenz
LIFE SCIENCE ALLIANCE
(2020)
Meeting Abstract
Oncology
Alan K. S. Chiang, Stephanie P. T. Yiu, Kwai F. Hui, Chung K. Choi, Richard Y. T. Kao, Dan Yang
Article
Oncology
Anthony P. Y. Liu, Janice J. K. Ip, Alex W. K. Leung, C. W. Luk, C. H. Li, Karin K. H. Ho, Regina Lo, Edwin K. W. Chan, Albert C. Y. Chan, Patrick H. Y. Chung, Alan K. S. Chiang
PEDIATRIC BLOOD & CANCER
(2019)
Meeting Abstract
Oncology
W. Chan, P. Lee, A. Chiang, D. Cheuk, G. Chan, Y. Ha
PEDIATRIC BLOOD & CANCER
(2018)
Meeting Abstract
Oncology
A. Chiang, A. P. Liu, A. W. Leung, C. W. Luk, C. H. Li, K. K. Ho, R. Lo, E. K. Chan, A. C. Chan, P. H. Chung, J. J. Ip
PEDIATRIC BLOOD & CANCER
(2018)
Meeting Abstract
Hematology
Birgit Burkhardt, Marta Pillon, Mary Taj, Nathalie Garnier, Veronique Minard, Volkan Hazar, Karin Mellgren, Tomoo Osumi, Alina Fedorova, Natalia Myakova, Jaime Verdu-Amoros, Mara Andres, Edita Kabickova, Andishe Attarbaschi, Alan Chiang, Eva Bubanska, Svetlana Donska, Lisa L. Hjalgrim, Jacek Wachowiak, Anna Pieczonka, Anne Uyttebroeck, Jan Loeffen, Jochen Buechner, Felix Niggli, Julia Palma, Amos Burke, Auke Beishuizen, Kristin Koeppen, Heidi Herbrueggen, Wilhelm Woessmann, Martin Zimmermann, Adriana Balduzzi
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Meeting Abstract
Hematology
Wilson Y. K. Chan, Alan K. S. Chiang
BRITISH JOURNAL OF HAEMATOLOGY
(2018)