DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth

(2013) Natividad Pozo et al.   JOURNAL OF CLINICAL INVESTIGATION

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

(2013) Camille L Novis et al.   Retrovirology

Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

(2012) M. Martinez de Lagran et al.   CEREBRAL CORTEX

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

(2011) Sebastiaan M. Bol et al.   PLoS One

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel HIV-1 Knockdown Targets Identified by an Enriched Kinases/Phosphatases shRNA Library Using a Long-Term Iterative Screen in Jurkat T-Cells

(2010) Sylvie Rato et al.   PLoS One

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

From experimental setup to bioinformatics: An RNAi screening platform to identify host factors involved in HIV-1 replication

(2009) Kathleen Börner et al.   Biotechnology Journal

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

(2009) Man Lung Yeung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of HIV-1 Activation by NF-κB—A Higher-Order Complex of p50:RelA Bound to the HIV-1 LTR

(2009) James C. Stroud et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence that Ecotropic Murine Leukemia Virus Contamination in TZM-bl Cells Does Not Affect the Outcome of Neutralizing Antibody Assays with Human Immunodeficiency Virus Type 1

(2009) E. J. Platt et al.   JOURNAL OF VIROLOGY

siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication

(2009) Kin-Hang Kok et al.   Retrovirology

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

(2008) Hye-Sook Kwon et al.   Cell Host & Microbe

Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways

(2008) Mohammed Rachidi et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Identification of Gammaretroviruses Constitutively Released from Cell Lines Used for Human Immunodeficiency Virus Research

(2008) Y. Takeuchi et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Isolation and propagation of HIV-1 on peripheral blood mononuclear cells

(2008) Angélique B van 't Wout et al.   Nature Protocols

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

Crystal Structure of NFAT Bound to the HIV-1 LTR Tandem κB Enhancer Element

(2008) Darren L. Bates et al.   STRUCTURE