Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation

Cyclophosphamide Alters the Gene Expression Profile in Patients Treated with High Doses Prior to Stem Cell Transplantation

(2014) Ibrahim El-Serafi et al.   PLoS One

Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3

(2012) Murali Subramanian et al.   Pharmacogenetics and Genomics

Pharmacokinetics of cyclophosphamide enantiomers in patients with breast cancer

(2011) Bruno José Dumêt Fernandes et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Q172H Replacement Overcomes Effects on the Metabolism of Cyclophosphamide and Efavirenz Caused by CYP2B6 Variant with Arg262

(2011) N. Ariyoshi et al.   DRUG METABOLISM AND DISPOSITION

Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients

(2011) Nasir Ali Afsar et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

(2011) H. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients

(2011) Hylke de Jonge et al.   PHARMACOGENOMICS

Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

(2010) Amit V. Pandey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene Polymorphisms in Cyclophosphamide Metabolism Pathway,Treatment-Related Toxicity, and Disease-Free Survival in SWOG 8897 Clinical Trial for Breast Cancer

(2010) S. Yao et al.   CLINICAL CANCER RESEARCH

A comparison between regimens containing chemotherapy alone (busulfan and cyclophosphamide) and chemotherapy (V. RAPID) plus total body irradiation on marrow engraftment following allogeneic bone marrow transplantation

(2010) Maura Reynolds et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19

(2010) Vishal Agrawal et al.   Pharmacogenetics and Genomics

Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro

(2010) Duanpen Sandee et al.   Pharmacogenetics and Genomics

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

(2009) Ana M Gomes et al.   PHARMACOGENOMICS

P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity

(2008) Steven N Hart et al.   Expert Opinion on Drug Metabolism & Toxicology

Clinical Applications of Blood-Derived and Marrow-Derived Stem Cells for Nonmalignant Diseases

(2008) Richard K. Burt   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION