Article
Nanoscience & Nanotechnology
Sebnem Gunes, Zhonglei He, David van Acken, Renee Malone, Patrick J. Cullen, James F. Curtin
Summary: Platinum nanoparticles (PtNPs) have shown potential protective effects against cold atmospheric plasma (CAP)-induced cytotoxicity, particularly in cancerous and non-cancerous cell lines. PtNPs effectively scavenge intracellular reactive oxygen and nitrogen species (RONS) and provide protection. While PtNPs do not significantly affect cell membrane permeabilization induced by CAP, they can reduce mitochondrial membrane depolarization.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Engineering, Environmental
Lingli Wang, Xu Lan, Wenya Peng, Zhaohui Wang
Summary: This review clarifies common mistakes and misinterpretations present in the literature regarding the identification of reactive radical species using quenching and electron paramagnetic resonance (EPR) tests. It aims to help researchers avoid errors when investigating catalytic oxidative mechanisms with these tests.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Polymer Science
Nikola Babic, Simon Pondaven, Herve Vezin
Summary: Autoxidation is a common spontaneous oxygen-mediated radical reaction in the degradation processes of hydrocarbon-based materials. In this study, EPR spin-trapping technique was used to investigate radical species involved in the autoxidation of synthetic base oil. The difference in generating radical species between aged and non-aged samples of the same base oil was studied by introducing oxygen and aging the samples at 140 degrees C.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Physics, Applied
B. Myers, P. Ranieri, T. Smirnova, P. Hewitt, D. Peterson, M. Herrera Quesada, E. Lenker, K. Stapelmann
Summary: Plasma-generated hydroxyl radicals and oxygen atoms were investigated, revealing that the HTA assay cannot distinguish between OH radicals and atomic oxygen, leading to inaccuracies in measuring aqueous OH densities. The experiments showed the significant role of atomic oxygen in plasma-induced liquid chemistry, highlighting the need for diagnostic techniques that take this into account.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Chemistry, Applied
Haniye Tolouie, Mohammad Amin Mohammadifar, Hamid Ghomi, Maryam Hashemi
Summary: The study investigated the effects of argon and nitrogen cold plasma treatments on the lipolytic enzymes activity in wheat germ. It was found that the efficiency of ACP treatment was influenced by the input gas and treatment time. The results suggested that ACP application for wheat germ stabilization could benefit from understanding the impact of input gas on enzyme activity.
Article
Infectious Diseases
Isabell Plattfaut, Manuela Besser, Anna-Lena Severing, Ewa K. Stuermer, Christian Oplaender
Summary: The antibacterial effects of CAP on Staphylococcus aureus were not significant, with no desired disinfection or reduction in bacterial burden in wet environments or biofilms. CAP treatment is not recommended as a standalone antibacterial therapy for wounds, but could be used to supplement standard treatments.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Physics, Multidisciplinary
A. Boudjadar, F. Bouanaka, S. Rebiai
Summary: In this study, a 2D axisymmetric fluid model for an atmospheric pressure plasma jet driven by an 8 kV voltage pulse was investigated using COMSOL@ Multi-physics software. The results identified physical phenomena occurring in a cold plasma jet at atmospheric pressure with an argon pathway, providing a platform for future plasma jet applications.
Article
Biochemistry & Molecular Biology
Benedikt Eggers, Matthias Bernhard Stope, Jana Marciniak, Werner Goetz, Alexander Mustea, James Deschner, Marjan Nokhbehsaim, Franz-Josef Kramer
Summary: This study investigated the effect of a medical argon plasma device on gingival cells. The results showed that an application time of 30 seconds was most suitable for treating gingival cells and tissue biopsies, providing evidence for the potential use of NIPP in dentistry.
Article
Physics, Applied
M. Bashir, S. Bashir, A. Javed, O. U. Noor
Summary: This study investigates the properties of an atmospheric pressure helium microplasma excited in a polydimethylsiloxane flow focusing microfluidic chip. The influence of input parameters on discharge characteristics is studied, and electron excitation and molecular rotational temperatures are determined. By utilizing plasma diagnostic techniques, the electron density and temperature are determined. The non-thermal equilibrium state of the microplasma is validated, and the plasma modified surface is successfully verified through the formation of an oil-in-water micro-emulsion.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Engineering, Chemical
Yung-Sen Lin, Hsiang-Yu Wan, Bing-Rong Wu
Summary: The adhesion of PTFE films to graphene-filled polyimide adhesives was significantly enhanced by argon cold atmospheric pressure plasmas, changing the surface from hydrophobic to hydrophilic and forming polar chemical bonds such as C-O and C=O.
POLYMER ENGINEERING AND SCIENCE
(2022)
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Engineering, Environmental
Xiaoqing Meng, Fangjuan Li, Li Yi, Mahlatsi Yorgan Dieketseng, Xiaomeng Wang, Lixiang Zhou, Guanyu Zheng
Summary: UV-based advanced oxidation processes (UV-AOPs) are effective in controlling the dissemination of antibiotic resistance in wastewater treatment plants (WWTP), but the mechanism of intracellular antibiotic resistance genes (i-ARGs) degradation by UV-AOPs is still unclear. This study found that UV in combination with hydrogen peroxide (UV/H2O2) or persulfate (UV/PDS) promoted the degradation of i-ARGs by generating free radicals that reacted with bacterial extracellular polymeric substances (EPS), increasing bacterial cell membrane permeability and facilitating UV irradiation to damage the i-ARGs.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Nima Bolouki, Wen-Hui Kuan, Yu-Yun Huang, Jang-Hsing Hsieh
Summary: The study shows that different gas species have a significant impact on the pH level, ORP level, nitrite/nitrate concentrations, and hydrogen peroxide content of plasma-activated water (PAW). Argon and oxygen plasmas do not significantly affect the pH level of PAW, while air and nitrogen plasmas cause a sharp decrease in pH during the treatment. Additionally, oxygen plasma provides the highest level of hydrogen peroxide, while argon plasma, despite consuming less power, still has relatively high hydrogen peroxide contents compared to nitrogen and air plasmas.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Panagiotis Svarnas, Michael Poupouzas, Konstantia Papalexopoulou, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, Athina Varemmenou, Evangelos Giannakopoulos, Christos D. Georgiou, Stavroula Georga, Christoforos Krontiras
Summary: This work focuses on the treatment of unbuffered and buffered water using atmospheric pressure cold plasma. The activation of these liquids by plasma-induced chemistry has potential applications in various fields. The study measures various properties of the treated liquids and investigates the reactions occurring in the plasma. The experimental results are compared with previous studies in a concise review.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Physics, Applied
Shohei Nakamura, Atsushi Tanide, Takahiro Kimura, Soichi Nadahara, Kenji Ishikawa, Osamu Oda, Masaru Hori
Summary: This study demonstrates damage-free atomic layer etching (ALE) of GaN using a cyclic process, where the chlorinated layer formed by Cl2 plasma exposure is removed by Ar plasma. A substrate temperature of 400 degrees C promotes etching even at lower ion energy, resulting in a higher ALE synergy of 62%. The proposed high temperature ALE method shows promise for achieving damage-free etching of GaN.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Swapnil Ghodke, Motoyuki Murashima, Dennis Christy, Ngo Van Nong, Kenji Ishikawa, Osamu Oda, Noritsugu Umehara, Masaru Hori
Summary: The mechanical properties, including compressive strength and modulus, of the maze-like CNW structure synthesized by RI-PECVD technique were analyzed using nanoindentation method, revealing an elastoplastic behavior.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Engineering, Electrical & Electronic
Phuc Duc Nguyen, Yoshifumi Shiraki, Kenji Ishikawa, Jun Muramatsu, Noboru Harada, Takehiro Moriya
Summary: We propose a two-level dimmer based on binary distribution matching for region-of-interest (RoI) signaling applications. Our extended multiset-partition distribution matching (EMPDM) algorithm with a novel binary-tree-structure implementation reduces the rate loss of the dimmer. Additionally, we introduce 4p-EMPDM, a compact version of EMPDM, which guarantees flicker mitigation for visible-light RoI signaling systems without using any run-length limited code.
IEEE PHOTONICS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ryusei Sakai, Hiroki Kondo, Kenji Ishikawa, Takayuki Ohta, Mineo Hiramatsu, Hiromasa Tanaka, Masaru Hori
Summary: Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) was performed using carbon nanowalls (CNWs) grown with the addition of oxygen in a mixture of CH4 and H2 gases. The high-quality CNWs had different crystallinity and C-OH groups compared to normal CNWs, but similar wall-to-wall distances and wettability. At a low laser fluence, the high-quality CNWs showed improved sensitivity for the detection of low-molecular-weight analytes while maintaining a high survival yield (SY) of 0.89.
Editorial Material
Physics, Multidisciplinary
Pankaj Attri, Kazunori Koga, Hirofumi Kurita, Kenji Ishikawa, Masaharu Shiratani
FRONTIERS IN PHYSICS
(2023)
Article
Physics, Applied
Shinji Yoshimura, Yoko Otsubo, Akira Yamashita, Katsuki Johzuka, Takayoshi Tsutsumi, Kenji Ishikawa, Masaru Hori
Summary: The characteristics of a gas-temperature-controllable atmospheric-pressure helium plasma jet and the development of an experimental system for cell viability assays of yeasts are described. The physicochemical properties of the plasma plume were similar to those of a typical helium plasma jet and allowed for maintaining a temperature suitable for yeast. The experimental system showed good reproducibility of cell viability and can be used for various experiments, including the identification of genes involved in resistance to direct plasma irradiation.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Physics, Applied
Yang Liu, Kenji Ishikawa, Hiromasa Tanaka, Camelia Miron, Takashi Kondo, Kae Nakamura, Masaaki Mizuno, Hiroaki Kajiyama, Shinya Toyokuni, Masaru Hori
Summary: Lactate, an important intermediate in the food and pharmaceutical industries, has been found to have effective antitumor action when exposed to plasma in Ringer's solution. This exposure leads to the production of small molecule aldehydes, ketones, and organic acids, as well as the formation of furanone isomers. The compound 2,3-Dimethyl-tartaric acid is believed to be the key component in the antitumor action, and various aqueous reaction mechanisms, including dehydration, esterification, hydrolysis, and dimerization, have been explained. This study has implications for the development of novel cancer therapies and the field of plasma organic chemistry.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Multidisciplinary Sciences
Deng-Ke Xi, Seong Ling Yap, Nitturi Naresh Kumar, Chian Cheng Toh, Kenji Ishikawa, Masaru Hori
Summary: Plasma assisted priming is effective in improving the germination rate and growth performance of papaya seeds.
Article
Materials Science, Multidisciplinary
Shih-Nan Hsiao, Nikolay Britun, Thi-Thuy-Nga Nguyen, Takayoshi Tsutsumi, Kenji Ishikawa, Makoto Sekine, Masaru Hori
Summary: The effects of substrate temperature on the etch rate and selectivity of PECVD-prepared SiN, SiO2, and a-C films were investigated. The etch rate of SiN was higher than that of SiO2 at all temperatures, and decreased as the temperature decreased. The etch rate of SiO2, on the other hand, increased with decreasing temperature. The selectivity of SiN over SiO2 reached unity at -20°C. The etch rate of a-C films remained constant regardless of temperature. The difference in FC thickness between SiN and SiO2 films accounted for the lower etch rate of SiO2, and the decrease in FC thickness at lower temperatures led to a decrease in etch rate. The higher stability of the surface N-H modification layer at low temperatures explained the decrease in etch rate for SiN etching, as confirmed by in situ FTIR.
Article
Multidisciplinary Sciences
Hiromasa Tanaka, Daijiro Iwata, Yuki Shibata, Tetsunari Hase, Daisuke Onoshima, Naoyuki Yogo, Hirofumi Shibata, Mitsuo Sato, Kenji Ishikawa, Ikuo Nagasawa, Yoshinori Hasegawa, Makoto Ishii, Yoshinobu Baba, Masaru Hori
Summary: Various liquid biopsy methods have been developed for non-invasive and early disease detection. Researchers have developed a glass filter that can capture circulating tumor cells (CTCs) and used it for detecting CTCs in lung cancer patients. They also developed a visualization system and demonstrated the direct culture of captured cells on the glass filter.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Taito Yoshie, Kenji Ishikawa, Thi-Thuy-Nga Nguyen, Shih-Nan Hsiao, Takayoshi Tsutsumi, Makoto Sekine, Masaru Hori
Summary: In the fabrication of semiconductor devices, the feature profiles of high-aspect-ratio Si trenches need to be controlled considering aspect-ratio-dependent etching. This control is achieved by a cyclic process involving sustained Ar plasma, alternating injection of C4F8 and SF6, and short-period substrate bias supply. The transient behaviors of gaseous and surface reactions are currently revealed through measurement of plasma parameters using a surface wave probe and optical emission spectroscopy. By fluorinating the etched surface during the cycle and controlling the bias-supply timing, an ARDE-free Si trench feature profile can be fabricated.
APPLIED SURFACE SCIENCE
(2023)
Article
Physics, Applied
Ma. Shanlene D. C. Dela Vega, Thi-Thuy-Nga Nguyen, Hiroki Kondo, Takayoshi Tsutsumi, Kenji Ishikawa, Masaru Hori
Summary: This work explores the application of the in-liquid plasma (ILP) process for carbon formation on ethanol-immersed metal substrates. Graphene, graphitic carbon, and amorphous carbon were produced simultaneously during plasma discharge. Graphitic and amorphous carbon coexisted on the metal substrate surface, while free-standing graphene formed in ethanol. The proposed mechanism for carbon formation on metal substrates is presented.
PLASMA PROCESSES AND POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Kenji Ishikawa, Keigo Takeda, Shinji Yoshimura, Takashi Kondo, Hiromasa Tanaka, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori
Summary: This review provides a historical background of the development of biological applications of low-temperature plasmas. It assesses the generation of plasma, methods and devices, plasma sources, and measurements of plasma properties. Currently, direct irradiation methods and indirect methods using plasma-treated liquids are being increasingly used in preclinical studies and cancer therapy. The authors discuss the prospects for further development in cancer therapeutic applications by understanding the interactions between the plasma and living organisms.
FREE RADICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaru Hori
Summary: Low-temperature plasma (LTP) has been widely used in life science. LTP can be used to irradiate water, medium, and Ringer's solutions to produce plasma-activated solutions, which contain chemical compounds produced by reactions among LTP, air, and solutions. Reactive oxygen and nitrogen species (RONS) are major components in plasma-activated solutions, and recent studies have shown the production of plasma-activated organic compounds in plasma-activated Ringer's lactate solution (PAL). In vitro and in vivo studies have demonstrated the anti-tumor effects of PAL on cancers, and biochemical analyses have revealed the intracellular molecular mechanisms of cancer cell death by PAL.
FREE RADICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Daisuke Onoshima, Tetsunari Hase, Naoto Kihara, Daiki Kuboyama, Hiromasa Tanaka, Naoya Ozawa, Hiroshi Yukawa, Mitsuo Sato, Kenji Ishikawa, Yoshinori Hasegawa, Makoto Ishii, Masaru Hori, Yoshinobu Baba
Summary: This study reports the use of a blood microfiltration device for noninvasive detection of circulating tumor cells (CTCs). The method efficiently separates and captures CTCs from whole blood, allowing for genomic profiling to evaluate tumor characteristics and treatment efficacy.
ACS MEASUREMENT SCIENCE AU
(2023)