FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia

A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxia

(2015) S. Anjomani Virmouni et al.   Disease Models & Mechanisms

Epigenetic therapy for Friedreich ataxia

(2014) Elisabetta Soragni et al.   ANNALS OF NEUROLOGY

Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length

(2014) Yogesh K. Chutake et al.   ANNALS OF NEUROLOGY

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia

(2014) Yogesh K. Chutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rating disease progression of Friedreich’s ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database

(2013) Günther Metz et al.   BRAIN

Friedreich Ataxia: Neuropathology Revised

(2013) Arnulf H. Koeppen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Friedreich Ataxia Clinical Outcome Measures

(2012) Sean R. Regner et al.   JOURNAL OF CHILD NEUROLOGY

Mammalian Frataxin Controls Sulfur Production and Iron Entry during de Novo Fe4S4 Cluster Assembly

(2012) Florent Colin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FXN methylation predicts expression and clinical outcome in Friedreich ataxia

(2011) Marguerite V. Evans-Galea et al.   ANNALS OF NEUROLOGY

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

(2011) Chiranjeevi Sandi et al.   NEUROBIOLOGY OF DISEASE

Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia

(2011) E. Kim et al.   NUCLEIC ACIDS RESEARCH

Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation

(2010) Tanel Punga et al.   EMBO Molecular Medicine

Repeat Expansion Affects Both Transcription Initiation and Elongation in Friedreich Ataxia Cells

(2010) Daman Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylation-sensitive high-resolution melting

(2009) Tomasz K Wojdacz et al.   Nature Protocols