Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo

PAMAM Dendrimers: Destined for Success or Doomed to Fail? Plain and Modified PAMAM Dendrimers in the Context of Biomedical Applications

(2015) Magdalena Labieniec-Watala et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanisms of and therapeutic approaches for overcoming resistance to epidermal growth factor receptor (EGFR)-targeted therapy in squamous cell carcinoma of the head and neck (SCCHN)

(2015) Katharine A.R. Price et al.   ORAL ONCOLOGY

Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice

(2015) Yang Sun et al.   Particle and Fibre Toxicology

Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

(2014) Yin Tang et al.   BIOMACROMOLECULES

Cationic PAMAM Dendrimers as Pore-Blocking Binary Toxin Inhibitors

(2014) Philip Förstner et al.   BIOMACROMOLECULES

Functional and biodegradable dendritic macromolecules with controlled architectures as nontoxic and efficient nanoscale gene vectors

(2014) Kui Luo et al.   BIOTECHNOLOGY ADVANCES

Transactivation of EGFR by G Protein-Coupled Receptor in the Pathophysiology of Intimal Hyperplasia

(2014) Swastika Sur et al.   Current Vascular Pharmacology

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

Can metabolic impairments in experimental diabetes be cured with poly(amido)amine (PAMAM) G4 dendrimers? – In the search for minimizing of the adverse effects of PAMAM administration

(2014) Magdalena Labieniec-Watala et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo

(2014) Dzmitry Shcharbin et al.   JOURNAL OF CONTROLLED RELEASE

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

(2014) Denise S. Conti et al.   MOLECULAR PHARMACEUTICS

Intracellular Ca2+ Release Mediates Cationic but Not Anionic Poly(amidoamine) (PAMAM) Dendrimer-Induced Tight Junction Modulation

(2014) Brittany R. Avaritt et al.   PHARMACEUTICAL RESEARCH

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases

(2014) Nicholas F. Endres et al.   TRENDS IN BIOCHEMICAL SCIENCES

EGFR inhibitors and autophagy in cancer treatment

(2014) Jie Cui et al.   TUMOR BIOLOGY

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Sodium selective ion channel formation in living cell membranes by polyamidoamine dendrimer

(2013) Gabriella Nyitrai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy

(2013) Esteban Durán-Lara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Poly(amidoamine) dendrimer complexes as a platform for gene delivery

(2013) Dzmitry Shcharbin et al.   Expert Opinion on Drug Delivery

On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR–ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells

(2013) Saghir Akhtar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction

(2013) Saghir Akhtar et al.   PLoS One

Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides

(2012) R. L. Juliano et al.   JOURNAL OF DRUG TARGETING

Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output

(2012) Jasminka Omerovic et al.   JOURNAL OF PROTEOME RESEARCH

Cationic PAMAM Dendrimers Disrupt Key Platelet Functions

(2012) Clinton F. Jones et al.   MOLECULAR PHARMACEUTICS

Efficient siRNA Delivery Using a Polyamidoamine Dendrimer with a Modified Pentaerythritol Core

(2012) Yue Zhang et al.   PHARMACEUTICAL RESEARCH

Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury

(2012) Saghir Akhtar et al.   PLoS One

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

(2012) S. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central Role of the EGF Receptor in Neurometabolic Aging

(2012) Sana Siddiqui et al.   International Journal of Endocrinology

Transepithelial transport and toxicity of PAMAM dendrimers: Implications for oral drug delivery

(2011) S. Sadekar et al.   ADVANCED DRUG DELIVERY REVIEWS

Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway

(2011) Saghir Akhtar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dendrosome-dendriplex inside liposomes: as a gene delivery system

(2011) Sara Movassaghian et al.   JOURNAL OF DRUG TARGETING

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

(2011) ANDREW ADVANI et al.   NEPHROLOGY

Use of poly(amido)amine dendrimers in prevention of early non-enzymatic modifications of biomacromolecules

(2010) Magdalena Labieniec et al.   BIOCHIMIE

Comparative Biodistribution of PAMAM Dendrimers and HPMA Copolymers in Ovarian-Tumor-Bearing Mice

(2010) S. Sadekar et al.   BIOMACROMOLECULES

Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics

(2010) Saghir Akhtar   Expert Opinion on Drug Metabolism & Toxicology

Evaluating the Gene-Expression Profiles of HeLa Cancer Cells Treated with Activated and Nonactivated Poly(amidoamine) Dendrimers, and Their DNA Complexes

(2010) Jung-hua Steven Kuo et al.   MOLECULAR PHARMACEUTICS

Dendrimer Internalization and Intracellular Trafficking in Living Cells

(2010) Lorenzo Albertazzi et al.   MOLECULAR PHARMACEUTICS

Effects of tempol and redox-cycling nitroxides in models of oxidative stress

(2010) Christopher S. Wilcox   PHARMACOLOGY & THERAPEUTICS

Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells

(2010) Sourav Prasanna Mukherjee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells

(2010) Pratap C. Naha et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Unexpected In Vivo Anti-Inflammatory Activity Observed for Simple, Surface Functionalized Poly(amidoamine) Dendrimers

(2009) Abhay S. Chauhan et al.   BIOMACROMOLECULES

Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity

(2009) Antos Shakhbazau et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vitro mammalian cytotoxicological study of PAMAM dendrimers – Towards quantitative structure activity relationships

(2009) Sourav Prasanna Mukherjee et al.   TOXICOLOGY IN VITRO

Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction

(2009) Jong-Ho Lee et al.   TOXICOLOGY LETTERS

Global upregulation of gene expression associated with renal dysfunction in DOCA–salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: A microarray analysis

(2009) Ibrahim F. Benter et al.   VASCULAR PHARMACOLOGY

Diabetic Nephropathy: Mechanisms of Renal Disease Progression

(2008) Yashpal S. Kanwar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

PAMAM G4 dendrimers lower high glucose but do not improve reduced survival in diabetic rats

(2008) Magdalena Labieniec et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS