Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation

P377Late sodium current as a promising drug target for treatment of atrial fibrillation?

(2014) C Poulet et al.   CARDIOVASCULAR RESEARCH

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

(2013) Serge Sicouri et al.   HEART RHYTHM

Na+ transport in the normal and failing heart — Remember the balance

(2013) Sanda Despa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation

(2012) Morten S. Olesen et al.   Circulation-Cardiovascular Genetics

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

(2012) S. Nattel et al.   EUROPEAN HEART JOURNAL

Comparison of Effectiveness and Safety of Ranolazine Versus Amiodarone for Preventing Atrial Fibrillation After Coronary Artery Bypass Grafting

(2011) Ronald H. Miles et al.   AMERICAN JOURNAL OF CARDIOLOGY

Independent and joint modulation of rat Nav1.6 voltage-gated sodium channels by coexpression with the auxiliary β1 and β2 subunits

(2011) Jianguo Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model

(2011) Marc D. Lemoine et al.   CARDIOVASCULAR RESEARCH

Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

(2011) Tamás Szél et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electrophysiologic basis for the antiarrhythmic actions of ranolazine

(2011) Charles Antzelevitch et al.   HEART RHYTHM

Role of ranolazine in angina, heart failure, arrhythmias, and diabetes

(2011) Samuel Sossalla et al.   PHARMACOLOGY & THERAPEUTICS

Re-Evaluation of the Action Potential Upstroke Velocity as a Measure of the Na+ Current in Cardiac Myocytes at Physiological Conditions

(2011) Géza Berecki et al.   PLoS One

Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3

(2010) Larissa Fabritz et al.   CARDIOVASCULAR RESEARCH

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

(2010) Andreas Blana et al.   HEART RHYTHM

Skeletal muscle stem cells propagated as myospheres display electrophysiological properties modulated by culture conditions

(2010) Claire Poulet et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

Regulation of sodium channel activity by phosphorylation

(2010) Todd Scheuer   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model

(2009) Yutao Xi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Rapid Kinetic Interactions of Ranolazine With HERG K+ Current

(2009) Sridharan Rajamani et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts

(2009) Ewa Soltysinska et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation

(2008) Begoña Benito et al.   HEART RHYTHM

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The cardiac persistent sodium current: an appealing therapeutic target?

(2007) D A Saint   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac sodium channel mutation in atrial fibrillation

(2007) Patrick T. Ellinor et al.   HEART RHYTHM

Late sodium current in failing heart: Friend or foe?

(2007) Victor A. Maltsev et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Ranolazine and late cardiac sodium current - a therapeutic target for angina, arrhythmia and more?

(2006) Jonathan C Makielski et al.   BRITISH JOURNAL OF PHARMACOLOGY